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Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.
Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM, Sun JP, Xu ZG. Guan Y, et al. Adv Sci (Weinh). 2023 Jun;10(16):e2205993. doi: 10.1002/advs.202205993. Epub 2023 Apr 17. Adv Sci (Weinh). 2023. PMID: 37066759 Free PMC article.
Yeast two-hybrid screening identified the E3 ligase WDSUB1 that binds to WHRN and regulates the ubiquitination of USH2A in a WHRN phosphorylation-dependent manner. ...
Yeast two-hybrid screening identified the E3 ligase WDSUB1 that binds to WHRN and regulates the ubiquitination of USH2A in a WHRN pho …
[WDSUB1 knockdown alleviates dextran sulfate sodium-induced colitis in mice by inhibiting nuclear factor-kappaB signaling pathway].
Wang S, Cui L, Liu X, Luo Z, Li H, Pu J. Wang S, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Aug 20;42(8):1119-1125. doi: 10.12122/j.issn.1673-4254.2022.08.02. Nan Fang Yi Ke Da Xue Xue Bao. 2022. PMID: 36073209 Free PMC article. Chinese.
OBJECTIVE: To explore the effect of WDSUB1 on dextran sulfate sodium (DSS)-induced inflammatory colon injury in mice and the underlying mechanism. ...RESULTS: The mRNA and protein expressions of WDSUB1 in the colon tissues were significantly lower in colitis mice wi …
OBJECTIVE: To explore the effect of WDSUB1 on dextran sulfate sodium (DSS)-induced inflammatory colon injury in mice and the underlyi …
The complex genetics of gait speed: genome-wide meta-analysis approach.
Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SL, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G. Ben-Avraham D, et al. Aging (Albany NY). 2017 Jan 10;9(1):209-246. doi: 10.18632/aging.101151. Aging (Albany NY). 2017. PMID: 28077804 Free PMC article.
Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the meta-analysis and pathway suggested that genetic effects on gait speed may occur through synaptic function and neuronal develop …
Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in add …
Genetic determinants of ferritin, haemoglobin levels and haemoglobin trajectories: results from Donor InSight.
Timmer T, Tanck M, Penkett C, Stirrups K, Gleadall N, de Kort W, van der Schoot E, van den Hurk K. Timmer T, et al. Vox Sang. 2021 Aug;116(7):755-765. doi: 10.1111/vox.13066. Epub 2021 Jan 25. Vox Sang. 2021. PMID: 33491795
Rs112016443 reached genome-wide significance for ferritin levels, which influences WDSUB1 expression. CONCLUSION: Rs112016443 was genome-wide significantly associated with ferritin levels in Dutch donors. ...
Rs112016443 reached genome-wide significance for ferritin levels, which influences WDSUB1 expression. CONCLUSION: Rs112016443 was gen …
Ancient origin of animal U-box ubiquitin ligases.
Marín I. Marín I. BMC Evol Biol. 2010 Oct 27;10:331. doi: 10.1186/1471-2148-10-331. BMC Evol Biol. 2010. PMID: 20979629 Free PMC article.
RESULTS: Phylogenetic and structural data indicate that six of the seven main UUL-encoding genes found in humans (UBE4A, UBE4B, UIP5, PRP19, CHIP and CYC4) were already present in the ancestor of all current metazoans and the seventh (WDSUB1) is found in placozoans, cnidar …
RESULTS: Phylogenetic and structural data indicate that six of the seven main UUL-encoding genes found in humans (UBE4A, UBE4B, UIP5, PRP19, …