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Page 1
Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates.
Webb GM, Sauter KA, Takahashi D, Kirigiti M, Bader L, Lindsley SR, Blomenkamp H, Zaro C, Shallman M, McGuire C, Hofmeister H, Avila U, Pessoa C, Hwang JM, McCullen A, Humkey M, Reed J, Gao L, Winchester L, Fletcher CV, Varlamov O, Brown TT, Sacha JB, Kievit P, Roberts CT. Webb GM, et al. JCI Insight. 2024 Aug 8;9(18):e181968. doi: 10.1172/jci.insight.181968. JCI Insight. 2024. PMID: 39115937 Free PMC article.
Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection.
Ricciardi MJ, Rust LN, Pedreño-Lopez N, Yusova S, Biswas S, Webb GM, Gonzalez-Nieto L, Voigt TB, Louw JJ, Laurino FD, DiBello JR, Raué HP, Barber-Axthelm AM, Chun K, Uttke S, Raphael LMS, Yrizarry-Medina A, Rosen BC, Agnor R, Gao L, Labriola C, Axthelm M, Smedley J, Julander JG, Bonaldo MC, Walker LM, Messaoudi I, Slifka MK, Burton DR, Kallas EG, Sacha JB, Watkins DI, Burwitz BJ. Ricciardi MJ, et al. Among authors: webb gm. Sci Transl Med. 2023 Mar 29;15(689):eade5795. doi: 10.1126/scitranslmed.ade5795. Epub 2023 Mar 29. Sci Transl Med. 2023. PMID: 36989376 Free PMC article.
Immune restoration by TIGIT blockade is insufficient to control chronic SIV infection.
Webb GM, Pessoa CT, McCullen AJ, Hwang JM, Humkey MC, Thormin-Odum R, Kukula KA, Smedley J, Fischer M, Sciurba J, Bochart RM, Shriver-Munsch C, Ndhlovu LC, Sacha JB. Webb GM, et al. J Virol. 2024 Jun 13;98(6):e0027324. doi: 10.1128/jvi.00273-24. Epub 2024 May 22. J Virol. 2024. PMID: 38775481 Free PMC article.
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.
Chang XL, Webb GM, Wu HL, Greene JM, Abdulhaqq S, Bateman KB, Reed JS, Pessoa C, Weber WC, Maier N, Chew GM, Gilbride RM, Gao L, Agnor R, Giobbi T, Torgerson J, Siess D, Burnett N, Fischer M, Shiel O, Moats C, Patterson B, Dhody K, Kelly S, Pourhassan N, Magnani DM, Smedley J, Bimber BN, Haigwood NL, Hansen SG, Brown TR, Ndhlovu LC, Sacha JB. Chang XL, et al. Among authors: webb gm. Nat Commun. 2021 Jun 7;12(1):3343. doi: 10.1038/s41467-021-23697-6. Nat Commun. 2021. PMID: 34099693 Free PMC article.
Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species.
Chang XL, Reed JS, Webb GM, Wu HL, Le J, Bateman KB, Greene JM, Pessoa C, Waytashek C, Weber WC, Hwang J, Fischer M, Moats C, Shiel O, Bochart RM, Crank H, Siess D, Giobbi T, Torgerson J, Agnor R, Gao L, Dhody K, Lalezari JP, Bandar IS, Carnate AM, Pang AS, Corley MJ, Kelly S, Pourhassan N, Smedley J, Bimber BN, Hansen SG, Ndhlovu LC, Sacha JB. Chang XL, et al. Among authors: webb gm. PLoS Pathog. 2022 Mar 31;18(3):e1010396. doi: 10.1371/journal.ppat.1010396. eCollection 2022 Mar. PLoS Pathog. 2022. PMID: 35358290 Free PMC article.
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques.
Zikos J, Webb GM, Wu HL, Reed JS, Watanabe J, Usachenko JL, Shaqra AM, Schiffer CA, Van Rompay KKA, Sacha JB, Magnani DM. Zikos J, et al. Among authors: webb gm. MAbs. 2024 Jan-Dec;16(1):2406788. doi: 10.1080/19420862.2024.2406788. Epub 2024 Sep 26. MAbs. 2024. PMID: 39324549 Free PMC article.
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab.
Chang XL, Wu HL, Webb GM, Tiwary M, Hughes C, Reed JS, Hwang J, Waytashek C, Boyle C, Pessoa C, Sylwester AW, Morrow D, Belica K, Fischer M, Kelly S, Pourhassan N, Bochart RM, Smedley J, Recknor CP, Hansen SG, Sacha JB. Chang XL, et al. Among authors: webb gm. Front Immunol. 2021 Nov 19;12:794638. doi: 10.3389/fimmu.2021.794638. eCollection 2021. Front Immunol. 2021. PMID: 34868084 Free PMC article. Clinical Trial.
CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14.
Patterson BK, Seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J, Pang APS, Sugai C, Mahyari E, Francisco EB, Pise A, Rodrigues H, Wu HL, Webb GM, Park BS, Kelly S, Pourhassan N, Lelic A, Kdouh L, Herrera M, Hall E, Bimber BN, Plassmeyer M, Gupta R, Alpan O, O'Halloran JA, Mudd PA, Akalin E, Ndhlovu LC, Sacha JB. Patterson BK, et al. Among authors: webb gm. Int J Infect Dis. 2021 Feb;103:25-32. doi: 10.1016/j.ijid.2020.10.101. Epub 2020 Nov 10. Int J Infect Dis. 2021. PMID: 33186704 Free PMC article.
Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes.
Burwitz BJ, Wu HL, Abdulhaqq S, Shriver-Munsch C, Swanson T, Legasse AW, Hammond KB, Junell SL, Reed JS, Bimber BN, Greene JM, Webb GM, Northrup M, Laub W, Kievit P, MacAllister R, Axthelm MK, Ducore R, Lewis A, Colgin LMA, Hobbs T, Martin LD, Ferguson B, Thomas CR Jr, Panoskaltsis-Mortari A, Meyers G, Stanton JJ, Maziarz RT, Sacha JB. Burwitz BJ, et al. Among authors: webb gm. Nat Commun. 2017 Nov 10;8(1):1418. doi: 10.1038/s41467-017-01631-z. Nat Commun. 2017. PMID: 29127275 Free PMC article.
The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.
Webb GM, Li S, Mwakalundwa G, Folkvord JM, Greene JM, Reed JS, Stanton JJ, Legasse AW, Hobbs T, Martin LD, Park BS, Whitney JB, Jeng EK, Wong HC, Nixon DF, Jones RB, Connick E, Skinner PJ, Sacha JB. Webb GM, et al. Blood Adv. 2018 Jan 23;2(2):76-84. doi: 10.1182/bloodadvances.2017012971. Blood Adv. 2018. PMID: 29365313 Free PMC article.
21 results