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Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers.
CPT Pharmacometrics Syst Pharmacol. 2022 Jun;11(6):755-765. doi: 10.1002/psp4.12787. Epub 2022 Apr 22.
CPT Pharmacometrics Syst Pharmacol. 2022.
PMID: 35385609
Free PMC article.
Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.
Chetty M, Cain T, Wedagedera J, Rostami-Hodjegan A, Jamei M.
Chetty M, et al. Among authors: wedagedera j.
Front Pharmacol. 2018 Mar 27;9:247. doi: 10.3389/fphar.2018.00247. eCollection 2018.
Front Pharmacol. 2018.
PMID: 29636682
Free PMC article.
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Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses.
Zhang Z, Imperial MZ, Patilea-Vrana GI, Wedagedera J, Gaohua L, Unadkat JD.
Zhang Z, et al. Among authors: wedagedera j.
Drug Metab Dispos. 2017 Aug;45(8):920-938. doi: 10.1124/dmd.117.075192. Epub 2017 Jun 6.
Drug Metab Dispos. 2017.
PMID: 28588050
Free PMC article.
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Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs.
Gaohua L, Wedagedera J, Small BG, Almond L, Romero K, Hermann D, Hanna D, Jamei M, Gardner I.
Gaohua L, et al. Among authors: wedagedera j.
CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):605-13. doi: 10.1002/psp4.12034. Epub 2015 Oct 9.
CPT Pharmacometrics Syst Pharmacol. 2015.
PMID: 26535161
Free PMC article.
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T-cell activation: A queuing theory analysis at low agonist density.
Wedagedera JR, Burroughs NJ.
Wedagedera JR, et al.
Biophys J. 2006 Sep 1;91(5):1604-18. doi: 10.1529/biophysj.105.066001. Epub 2006 Jun 9.
Biophys J. 2006.
PMID: 16766611
Free PMC article.
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