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Human TRMT2A methylates tRNA and contributes to translation fidelity.
Witzenberger M, Burczyk S, Settele D, Mayer W, Welp LM, Heiss M, Wagner M, Monecke T, Janowski R, Carell T, Urlaub H, Hauck SM, Voigt A, Niessing D. Witzenberger M, et al. Nucleic Acids Res. 2023 Sep 8;51(16):8691-8710. doi: 10.1093/nar/gkad565. Nucleic Acids Res. 2023. PMID: 37395448 Free PMC article.
Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.
Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G. Margreiter MA, et al. Among authors: witzenberger m. Comput Struct Biotechnol J. 2021 Dec 28;20:443-458. doi: 10.1016/j.csbj.2021.12.029. eCollection 2022. Comput Struct Biotechnol J. 2021. PMID: 35070167 Free PMC article.
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling.
Yampolsky P, Koenen M, Mosqueira M, Geschwill P, Nauck S, Witzenberger M, Seyler C, Fink T, Kruska M, Bruehl C, Schwoerer AP, Ehmke H, Fink RHA, Draguhn A, Thomas D, Katus HA, Schweizer PA. Yampolsky P, et al. Among authors: witzenberger m. Nat Commun. 2019 Jul 23;10(1):3295. doi: 10.1038/s41467-019-11261-2. Nat Commun. 2019. PMID: 31337768 Free PMC article.