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Page 1
The ribosome lowers the entropic penalty of protein folding.
Streit JO, Bukvin IV, Chan SHS, Bashir S, Woodburn LF, Włodarski T, Figueiredo AM, Jurkeviciute G, Sidhu HK, Hornby CR, Waudby CA, Cabrita LD, Cassaignau AME, Christodoulou J. Streit JO, et al. Among authors: wlodarski t. Nature. 2024 Sep;633(8028):232-239. doi: 10.1038/s41586-024-07784-4. Epub 2024 Aug 7. Nature. 2024. PMID: 39112704 Free PMC article.
The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein.
Chan SHS, Włodarski T, Streit JO, Cassaignau AME, Woodburn LF, Ahn M, Freiherr von Sass GJ, Waudby CA, Budisa N, Cabrita LD, Christodoulou J. Chan SHS, et al. Among authors: wlodarski t. Nat Chem. 2022 Oct;14(10):1165-1173. doi: 10.1038/s41557-022-01004-0. Epub 2022 Aug 4. Nat Chem. 2022. PMID: 35927328 Free PMC article.
Common sequence motifs of nascent chains engage the ribosome surface and trigger factor.
Deckert A, Cassaignau AME, Wang X, Włodarski T, Chan SHS, Waudby CA, Kirkpatrick JP, Vendruscolo M, Cabrita LD, Christodoulou J. Deckert A, et al. Among authors: wlodarski t. Proc Natl Acad Sci U S A. 2021 Dec 28;118(52):e2103015118. doi: 10.1073/pnas.2103015118. Proc Natl Acad Sci U S A. 2021. PMID: 34930833 Free PMC article.
A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.
Cabrita LD, Cassaignau AME, Launay HMM, Waudby CA, Wlodarski T, Camilloni C, Karyadi ME, Robertson AL, Wang X, Wentink AS, Goodsell L, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J. Cabrita LD, et al. Among authors: wlodarski t. Nat Struct Mol Biol. 2016 Apr;23(4):278-285. doi: 10.1038/nsmb.3182. Epub 2016 Feb 29. Nat Struct Mol Biol. 2016. PMID: 26926436 Free PMC article.
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis.
Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J. Waudby CA, et al. Among authors: wlodarski t. Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):9744-9749. doi: 10.1073/pnas.1716252115. Epub 2018 Sep 10. Proc Natl Acad Sci U S A. 2018. PMID: 30201720 Free PMC article.
14 results