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trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.
Holladay MW, Lin CW, May CS, Garvey DS, Witte DG, Miller TR, Wolfram CA, Nadzan AM. Holladay MW, et al. Among authors: wolfram ca. J Med Chem. 1991 Jan;34(1):455-7. doi: 10.1021/jm00105a068. J Med Chem. 1991. PMID: 1992147 No abstract available.