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An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016).
Polli JW, Olson KL, Chism JP, John-Williams LS, Yeager RL, Woodard SM, Otto V, Castellino S, Demby VE. Polli JW, et al. Among authors: woodard sm. Drug Metab Dispos. 2009 Feb;37(2):439-42. doi: 10.1124/dmd.108.024646. Epub 2008 Dec 4. Drug Metab Dispos. 2009. PMID: 19056914