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7,659 results

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Page 1
WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.
Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F. Hong X, et al. Theranostics. 2023 Feb 21;13(4):1311-1324. doi: 10.7150/thno.79326. eCollection 2023. Theranostics. 2023. PMID: 36923529 Free PMC article.
Methods: Ischemia-reperfusion injury (IRI) mouse model was used to investigate the expression pattern of WT1 in the kidney after severe AKI. Conditional deletion of WT1 gene mice were generated using Pax8(CreERT2) and WT1(fl/fl) mice to examine the function o …
Methods: Ischemia-reperfusion injury (IRI) mouse model was used to investigate the expression pattern of WT1 in the kidney after seve …
WT1 Disorder.
Lipska-Ziętkiewicz BS. Lipska-Ziętkiewicz BS. 2020 Apr 30 [updated 2021 Apr 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2020 Apr 30 [updated 2021 Apr 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 32352694 Free Books & Documents. Review.
GENETIC COUNSELING: WT1 disorder is inherited in an autosomal dominant manner. Most individuals diagnosed with WT1 disorder have the disorder as the result of an apparent de novo WT1 pathogenic variant; in rare instances, a parent of an individual with WT1 …
GENETIC COUNSELING: WT1 disorder is inherited in an autosomal dominant manner. Most individuals diagnosed with WT1 disorder ha …
The functions of Wt1 in mouse gonad development and somatic cells differentiation.
Chen M, Cen C, Wang N, Shen Z, Wang M, Liu B, Li J, Cui X, Wang Y, Gao F. Chen M, et al. Biol Reprod. 2022 Jul 25;107(1):269-274. doi: 10.1093/biolre/ioac050. Biol Reprod. 2022. PMID: 35244683 Review.
Wt1 has been found to be involved in the development of many organs. In gonads, Wt1 is expressed in genital ridge somatic cells before sex determination, and its expression is maintained in Sertoli cells and granulosa cells after sex determination. It has been demon …
Wt1 has been found to be involved in the development of many organs. In gonads, Wt1 is expressed in genital ridge somatic cell …
WT1 Alternative Splicing: Role of Its Isoforms in Neuroblastoma.
Rasà DM, D'Amico AG, Maugeri G, Cavallaro S, D'Agata V. Rasà DM, et al. J Mol Neurosci. 2017 Jun;62(2):131-141. doi: 10.1007/s12031-017-0930-0. Epub 2017 May 22. J Mol Neurosci. 2017. PMID: 28534317 Review.
Wilms tumor 1 (WT1), a tumor suppressor gene, was originally identified in the homonymous renal neoplasm but is also involved in other cancers. Its function is still unclear, since it acts both as a pro- and an anti-oncogene. At least 14 WT1 transcriptional variants …
Wilms tumor 1 (WT1), a tumor suppressor gene, was originally identified in the homonymous renal neoplasm but is also involved in othe …
Wilms tumor gent 1 (WT1)-specific adoptive immunotherapy in hematologic diseases.
Jiang Y, Lv X, Ge X, Qu H, Zhang Q, Lu K, Lu Y, Xue C, Zhang L, Wang X. Jiang Y, et al. Int Immunopharmacol. 2021 May;94:107504. doi: 10.1016/j.intimp.2021.107504. Epub 2021 Feb 28. Int Immunopharmacol. 2021. PMID: 33657524 Review.
As an attractive tumor-associated antigen (TAA), Wilms tumor gene 1 (WT1) is usually overexpressed in malignant hematological diseases. In recent years, WT1-specific adoptive immunotherapy has been the "hot spot" for tumor treatment. The main immunotherapeutic techn …
As an attractive tumor-associated antigen (TAA), Wilms tumor gene 1 (WT1) is usually overexpressed in malignant hematological disease …
WT1 and glomerular function.
Menke AL, Schedl A. Menke AL, et al. Semin Cell Dev Biol. 2003 Aug;14(4):233-40. doi: 10.1016/s1084-9521(03)00026-0. Semin Cell Dev Biol. 2003. PMID: 14627122 Review.
Disruption of WT1 may lead to a whole spectrum of kidney diseases ranging from tumour development to mild forms of renal failure. ...The development of mouse models in recent years has contributed considerably to a better understanding of the biological activities of WT …
Disruption of WT1 may lead to a whole spectrum of kidney diseases ranging from tumour development to mild forms of renal failure. ... …
Wt1 in the kidney--a tale in mouse models.
Ozdemir DD, Hohenstein P. Ozdemir DD, et al. Pediatr Nephrol. 2014 Apr;29(4):687-93. doi: 10.1007/s00467-013-2673-7. Epub 2013 Nov 18. Pediatr Nephrol. 2014. PMID: 24240471 Review.
The WT1 gene was originally identified through its involvement in the development of Wilms tumours. ...In this review we discuss the different models that have been generated and what they have taught us about the role of Wt1 in the kidney....
The WT1 gene was originally identified through its involvement in the development of Wilms tumours. ...In this review we discuss the …
The role of WT1 in breast cancer: clinical implications, biological effects and molecular mechanism.
Zhang Y, Yan WT, Yang ZY, Li YL, Tan XN, Jiang J, Zhang Y, Qi XW. Zhang Y, et al. Int J Biol Sci. 2020 Feb 24;16(8):1474-1480. doi: 10.7150/ijbs.39958. eCollection 2020. Int J Biol Sci. 2020. PMID: 32210734 Free PMC article. Review.
Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies have demonstrated that it can also play an oncogenic role in leukemia and various solid tumors. WT1 exerts biological functions with h …
Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor gene in nephroblastoma, subsequent studies h …
WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy.
Sugiyama H. Sugiyama H. Jpn J Clin Oncol. 2010 May;40(5):377-87. doi: 10.1093/jjco/hyp194. Epub 2010 Apr 15. Jpn J Clin Oncol. 2010. PMID: 20395243 Review.
The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia. ...Clinical trials of WT1-targeted immunotherapy have confirmed its safety and …
The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for t …
WT1 peptide vaccine for the treatment of cancer.
Oka Y, Tsuboi A, Oji Y, Kawase I, Sugiyama H. Oka Y, et al. Curr Opin Immunol. 2008 Apr;20(2):211-20. doi: 10.1016/j.coi.2008.04.009. Epub 2008 May 24. Curr Opin Immunol. 2008. PMID: 18502632 Review.
Wilms' tumor gene WT1 is expressed in various kinds of cancers. Human WT1-specific cytotoxic T lymphocytes (CTLs) were generated, and mice immunized with WT1 peptide rejected challenges by WT1-expressing cancer cells without auto-aggression to normal o …
Wilms' tumor gene WT1 is expressed in various kinds of cancers. Human WT1-specific cytotoxic T lymphocytes (CTLs) were generat …
7,659 results