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65 results

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Page 1
WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia.
Zhu Y, Tong X, Wang Y, Lu X. Zhu Y, et al. Cell Death Dis. 2021 Dec 20;13(1):18. doi: 10.1038/s41419-021-04467-0. Cell Death Dis. 2021. PMID: 34930905 Free PMC article.
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strategies are required. Emerging evidence suggests that WTIP is a candidate tumor suppressor. However, the molecular mechanisms of WTIP …
Acute myeloid leukemia (AML) is an aggressive and heterogeneous clonal hematologic malignancy for which novel therapeutic targets and strate …
Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy.
De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA. De Jong HN, et al. Circ Genom Precis Med. 2022 Aug;15(4):e003563. doi: 10.1161/CIRCGEN.121.003563. Epub 2022 Jun 7. Circ Genom Precis Med. 2022. PMID: 35671065 Free PMC article.
Here, we describe a novel HCM-associated variant in the noncanonical Wnt signaling interactor WTIP (Wilms tumor interacting protein) and provide evidence of a role for WTIP in complex disease. ...We performed weighted gene coexpression network analysis for WTIP …
Here, we describe a novel HCM-associated variant in the noncanonical Wnt signaling interactor WTIP (Wilms tumor interacting protein) …
Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.
Madhavan SM, Konieczkowski M, Bruggeman LA, DeWalt M, Nguyen JK, O'Toole JF, Sedor JR. Madhavan SM, et al. Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F272-F287. doi: 10.1152/ajprenal.00051.2022. Epub 2022 Jul 21. Am J Physiol Renal Physiol. 2022. PMID: 35862649 Free PMC article.
To define Wtip expression and function in the kidney, we created a Wtip-deleted mouse model using beta-galactosidase-neomycin (beta-geo) gene trap technology. Wtip gene trap mice were embryonic lethal, suggesting additional developmental roles outside kidney …
To define Wtip expression and function in the kidney, we created a Wtip-deleted mouse model using beta-galactosidase-neomycin …
AJUBA and WTIP can compete with LIMD1 for junctional localization and LATS regulation.
Kirichenko E, Irvine KD. Kirichenko E, et al. MicroPubl Biol. 2022 Nov 9;2022:10.17912/micropub.biology.000666. doi: 10.17912/micropub.biology.000666. eCollection 2022. MicroPubl Biol. 2022. PMID: 36439396 Free PMC article.
Each of the three mammalian Ajuba family proteins, AJUBA, LIMD1 and WTIP, exhibit tension-dependent localization to adherens junctions, and can associate with Lats kinases. ...To assess the relationship of LIMD1 to AJUBA and WTIP, and the potential contributions of …
Each of the three mammalian Ajuba family proteins, AJUBA, LIMD1 and WTIP, exhibit tension-dependent localization to adherens junction …
WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.
Khan FF, Li Y, Balyan A, Wang QT. Khan FF, et al. Biochem Biophys Res Commun. 2014 Aug 15;451(1):101-6. doi: 10.1016/j.bbrc.2014.07.080. Epub 2014 Jul 24. Biochem Biophys Res Commun. 2014. PMID: 25065743
Here, we identify a novel ASXL2-binding partner, the LIM domain-containing protein WTIP. Genetic and biochemical assays show a direct interaction between ASXL2 and WTIP. In HeLa cells, ASXL2 enhances retinoic acid-dependent luciferase activity, while WTIP rep …
Here, we identify a novel ASXL2-binding partner, the LIM domain-containing protein WTIP. Genetic and biochemical assays show a direct …
Identification of the UBA2-WTIP fusion gene in acute myeloid leukemia.
Lu X, Zhuang H, Yu Q, Zhang X, Wu Z, Zhang L, Xu Y, Wu B, Yang L, Ma A, Gan X, Yu X, Shen J, Xu R. Lu X, et al. Exp Cell Res. 2018 Oct 15;371(2):409-416. doi: 10.1016/j.yexcr.2018.08.035. Epub 2018 Sep 1. Exp Cell Res. 2018. PMID: 30179602 Free article.
Here we identified an intrachromosomal fusion gene located on chromosome 19q.13 between UBA2 and WTIP gene in a case of acute myeloid leukemia. The UBA2-WTIP fusion gene contains the N-terminal E1_enzyme_family, VAE_Ubl domains of UBA2, and the C-terminal LIM domain …
Here we identified an intrachromosomal fusion gene located on chromosome 19q.13 between UBA2 and WTIP gene in a case of acute myeloid …
Wtip is required for proepicardial organ specification and cardiac left/right asymmetry in zebrafish.
Powell R, Bubenshchikova E, Fukuyo Y, Hsu C, Lakiza O, Nomura H, Renfrew E, Garrity D, Obara T. Powell R, et al. Mol Med Rep. 2016 Sep;14(3):2665-78. doi: 10.3892/mmr.2016.5550. Epub 2016 Jul 27. Mol Med Rep. 2016. PMID: 27484451 Free PMC article.
WT1 is expressed in the proepicardial organ (PE) of the heart, and mouse and zebrafish wt1 knockout models appear to lack the PE. Wtip's role in the heart remains unexplored. In the present study, we demonstrate that wtip expression is identical in wt1a-, tcf21-, an …
WT1 is expressed in the proepicardial organ (PE) of the heart, and mouse and zebrafish wt1 knockout models appear to lack the PE. Wtip …
YAP/TAZ enhances P-body formation to promote tumorigenesis.
Shen X, Peng X, Guo Y, Dai Z, Cui L, Yu W, Liu Y, Liu CY. Shen X, et al. Elife. 2024 Jul 24;12:RP88573. doi: 10.7554/eLife.88573. Elife. 2024. PMID: 39046443 Free PMC article.
Mechanistically, both transcriptional activation of the P-body-related genes SAMD4A, AJUBA, and WTIP and transcriptional suppression of the tumor suppressor gene PNRC1 are involved in enhancing the effects of YAP/TAZ on P-body formation in colorectal cancer (CRC) cells. .. …
Mechanistically, both transcriptional activation of the P-body-related genes SAMD4A, AJUBA, and WTIP and transcriptional suppression …
WTIP interacts with BRCA2 and is essential for BRCA2 centrosome localization in cervical cancer cell.
Zhang J, Xu J, Wang G, Sun P, Yan T, Zhao X. Zhang J, et al. Arch Gynecol Obstet. 2016 Nov;294(6):1311-1316. doi: 10.1007/s00404-016-4176-9. Epub 2016 Aug 18. Arch Gynecol Obstet. 2016. PMID: 27535760
Coimmunoprecipitation and glutathione S-transferase (GST) pull-down assays were performed to detect protein-protein interaction between BRCA2 and hemaglutinin (HA)-WTIP. The expression of WTIP was silenced by short hairpin RNA (shRNA) and the levels of WTIP w …
Coimmunoprecipitation and glutathione S-transferase (GST) pull-down assays were performed to detect protein-protein interaction between BRCA …
Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis.
Bubenshchikova E, Ichimura K, Fukuyo Y, Powell R, Hsu C, Morrical SO, Sedor JR, Sakai T, Obara T. Bubenshchikova E, et al. Biol Open. 2012 Jun 15;1(6):588-96. doi: 10.1242/bio.20121016. Epub 2012 May 4. Biol Open. 2012. PMID: 23213452 Free PMC article.
We report Wtip is enriched in the basal body and knockdown of wtip leads to pronephric cyst formation, cloaca malformation, hydrocephalus, body curvature, and pericardial edema. ...Furthermore, we demonstrate that wtip and vangl2 interact genetically. Taken t …
We report Wtip is enriched in the basal body and knockdown of wtip leads to pronephric cyst formation, cloaca malformation, hy …
65 results