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46 results

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Page 1
WWC2 expression in the testis: Implications for spermatogenesis and male fertility.
Höffken V, Di Persio S, Laurentino S, Wyrwoll MJ, Terwort N, Hermann A, Röpke A, Oud MS, Wistuba J, Kliesch S, Pavenstädt HJ, Tüttelmann F, Neuhaus N, Kremerskothen J. Höffken V, et al. FASEB J. 2023 May;37(5):e22912. doi: 10.1096/fj.202200960R. FASEB J. 2023. PMID: 37086090
While all three WWC family members WWC1, WWC2, and WWC3 are found co-expressed in most human organs including lung, brain, kidney, and liver, in the testis only WWC2 displays a relatively high expression. ...Taken together, our findings provide novel insights into t …
While all three WWC family members WWC1, WWC2, and WWC3 are found co-expressed in most human organs including lung, brain, kidney, an …
WWC2 modulates GABA(A)-receptor-mediated synaptic transmission, revealing class-specific mechanisms of synapse regulation by WWC family proteins.
Dunham TL, Wilkerson JR, Johnson RC, Huganir RL, Volk LJ. Dunham TL, et al. Cell Rep. 2024 Oct 22;43(10):114841. doi: 10.1016/j.celrep.2024.114841. Epub 2024 Oct 10. Cell Rep. 2024. PMID: 39388350 Free PMC article.
The WW and C2 domain-containing protein (WWC2) is implicated in several neurological disorders. Here, we demonstrate that WWC2 interacts with inhibitory, but not excitatory, postsynaptic scaffolds, consistent with prior proteomic identification of WWC2 as a p …
The WW and C2 domain-containing protein (WWC2) is implicated in several neurological disorders. Here, we demonstrate that WWC2 …
m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay.
Zhu X, Zhang P. Zhu X, et al. J Transl Med. 2024 Oct 14;22(1):931. doi: 10.1186/s12967-024-05716-4. J Transl Med. 2024. PMID: 39402642 Free PMC article.
Furthermore, circXPO1 interacted with FMRP to reduce the mRNA stability of WWC2, which consequently resulted in Hippo-YAP pathway activation. Rescue experiments suggested that WWC2 overexpression abrogated circXPO1-mediated malignant capacities of CRC cells. The in …
Furthermore, circXPO1 interacted with FMRP to reduce the mRNA stability of WWC2, which consequently resulted in Hippo-YAP pathway act …
Wwc2 Is a Novel Cell Division Regulator During Preimplantation Mouse Embryo Lineage Formation and Oogenesis.
Virnicchi G, Bora P, Gahurova L, Šušor A, Bruce AW. Virnicchi G, et al. Front Cell Dev Biol. 2020 Sep 17;8:857. doi: 10.3389/fcell.2020.00857. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33042987 Free PMC article.
Oocyte and embryo cell division defects, each occurring in the absence of centrosomes, are fully reversible by expression of recombinant HA-epitope tagged WWC2, restoring activated oocyte AURKA levels. Additionally, clonal embryonic dysregulation implicates Wwc2 in …
Oocyte and embryo cell division defects, each occurring in the absence of centrosomes, are fully reversible by expression of recombinant HA- …
CLK1 Activates YAP to Promote Intrahepatic Cholangiocarcinogenesis.
Xue S, Chen X, Qiu G, Liao H, Qiang Z, Zhang Z, Feng X, Xu L, Xie R, Zhou H, Huang J, Zeng Y, Wang H. Xue S, et al. Cancer Res. 2025 Mar 14;85(6):1035-1048. doi: 10.1158/0008-5472.CAN-24-0147. Cancer Res. 2025. PMID: 39693605
Mechanistically, 4D label-free mass spectrometry and coimmunoprecipitation assays revealed WWC2 as a potential mediator of the CLK1-YAP cascade. Collectively, the current findings identify a critical role for CLK1 in promoting ICC development and indicate that inhibiting Y …
Mechanistically, 4D label-free mass spectrometry and coimmunoprecipitation assays revealed WWC2 as a potential mediator of the CLK1-Y …
LncRNA WWC2-AS1 functions AS a novel competing endogenous RNA in the regulation of FGF2 expression by sponging miR-16 in radiation-induced intestinal fibrosis.
Zhou JM, Liang R, Zhu SY, Wang H, Zou M, Zou WJ, Nie SL. Zhou JM, et al. BMC Cancer. 2019 Jul 1;19(1):647. doi: 10.1186/s12885-019-5754-6. BMC Cancer. 2019. PMID: 31262262 Free PMC article.
The significance of WWC2-AS1 in regulating FGF2 associated proliferation, migration, invasion and fibrosis of CCD-18Co and SEMFs by exposure to radiation was analyzed by shRNA (WWC2-AS1 shRNA) knock-down of endogenous WWC2-AS1. ...Targeting WWC2-AS1 th …
The significance of WWC2-AS1 in regulating FGF2 associated proliferation, migration, invasion and fibrosis of CCD-18Co and SEMFs by e …
The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice.
Hermann A, Wu G, Nedvetsky PI, Brücher VC, Egbring C, Bonse J, Höffken V, Wennmann DO, Marks M, Krahn MP, Schöler H, Heiduschka P, Pavenstädt H, Kremerskothen J. Hermann A, et al. Cell Death Dis. 2021 Jan 22;12(1):117. doi: 10.1038/s41419-021-03409-0. Cell Death Dis. 2021. PMID: 33483469 Free PMC article.
In contrast, we could show here that ubiquitous deletion of Wwc2 in mice leads to early embryonic lethality. Wwc2 KO embryos display growth retardation, a disturbed placenta development, impaired vascularization, and finally embryonic death. ...In summary, our data …
In contrast, we could show here that ubiquitous deletion of Wwc2 in mice leads to early embryonic lethality. Wwc2 KO embryos d …
WWC2 is an independent prognostic factor and prevents invasion via Hippo signalling in hepatocellular carcinoma.
Zhang Y, Yan S, Chen J, Gan C, Chen D, Li Y, Wen J, Kremerskothen J, Chen S, Zhang J, Cao Y. Zhang Y, et al. J Cell Mol Med. 2017 Dec;21(12):3718-3729. doi: 10.1111/jcmm.13281. Epub 2017 Aug 16. J Cell Mol Med. 2017. PMID: 28815883 Free PMC article.
However, the expression and clinicopathologic significance of WWC2 in cancer are poorly characterized. This study aimed to clarify the biological function and mechanism of action of WWC2 in hepatocellular carcinoma (HCC). ...Positive WWC2 expression was assoc …
However, the expression and clinicopathologic significance of WWC2 in cancer are poorly characterized. This study aimed to clarify th …
Modulation of GABA (A) receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins.
Dunham TL, Wilkerson JR, Johnson RC, Huganir RL, Volk LJ. Dunham TL, et al. bioRxiv [Preprint]. 2024 Mar 12:2024.03.11.584487. doi: 10.1101/2024.03.11.584487. bioRxiv. 2024. Update in: Cell Rep. 2024 Oct 22;43(10):114841. doi: 10.1016/j.celrep.2024.114841. PMID: 38559047 Free PMC article. Updated. Preprint.
Here, we demonstrate that WWC2 interacts with inhibitory but not excitatory postsynaptic scaffolds, consistent with prior proteomic identification of WWC2 as a putative component of the inhibitory postsynaptic density. ...Inhibitory synaptic transmission is dysregul …
Here, we demonstrate that WWC2 interacts with inhibitory but not excitatory postsynaptic scaffolds, consistent with prior proteomic i …
Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice.
Brücher VC, Egbring C, Plagemann T, Nedvetsky PI, Höffken V, Pavenstädt H, Eter N, Kremerskothen J, Heiduschka P. Brücher VC, et al. Int J Mol Sci. 2021 May 18;22(10):5321. doi: 10.3390/ijms22105321. Int J Mol Sci. 2021. PMID: 34070186 Free PMC article.
The branching and end points in the peripheral plexus were significantly increased compared to the control group. The deletion of the WWC2 gene was decisive for these effects; while knocking out WWC1 showed no significant differences. The results hint strongly that WWC2 …
The branching and end points in the peripheral plexus were significantly increased compared to the control group. The deletion of the WWC …
46 results