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Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production.
Sławińska-Brych A, Zdzisińska B, Czerwonka A, Mizerska-Kowalska M, Dmoszyńska-Graniczka M, Stepulak A, Gagoś M. Sławińska-Brych A, et al. Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129408. doi: 10.1016/j.bbagen.2019.08.001. Epub 2019 Aug 3. Biochim Biophys Acta Gen Subj. 2019. PMID: 31386885
However, the mechanisms by which XN affects the survival of multiple myeloma cells (MM) are little known. Therefore, our study was undertaken to address this issue. ...GENERAL SIGNIFICANCE: The advanced understanding of the molecular mechanisms of XN action can be u …
However, the mechanisms by which XN affects the survival of multiple myeloma cells (MM) are little known. Therefore, our study …
Multiple myeloma inhibitory effects of natural compounds: enhancement through nanoparticle carriers.
Wong E, Staskiewicz A, Pruner J, Lee J, Tucker M, Smith B, Rogers L, Asuni G, Wang X. Wong E, et al. Front Pharmacol. 2025 Jun 17;16:1589090. doi: 10.3389/fphar.2025.1589090. eCollection 2025. Front Pharmacol. 2025. PMID: 40599807 Free PMC article. Review.
Natural compounds have emerged as promising therapeutic agents for treating cancers such as multiple myeloma (MM). However, poor bioavailability, low stability, and suboptimal targeting often limit their clinical efficacy. ...This review explores the inhibitory effe …
Natural compounds have emerged as promising therapeutic agents for treating cancers such as multiple myeloma (MM). However, po …
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Harikumar KB, et al. Blood. 2009 Feb 26;113(9):2003-13. doi: 10.1182/blood-2008-04-151944. Epub 2008 Oct 24. Blood. 2009. PMID: 18952893 Free PMC article.
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic properties through an undefined mechanism. Whether examined by intracellular esterase activity, phosphatidylserine externalization, DNA strand …
Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits anti-inflammatory, antiproliferative, and antiangiogenic pr …