Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.
Klebba JE, Roy N, Bernard SM, Grabow S, Hoffman MA, Miao H, Tamiya J, Wang J, Berry C, Esparza-Oros A, Lin R, Liu Y, Pariollaud M, Parker H, Mochalkin I, Rana S, Snead AN, Walton EJ, Wyrick TE, Aitichson E, Bedke K, Brannon JC, Chick JM, Hee K, Horning BD, Ismail M, Lamb KN, Lin W, Lu J, Pastuszka MK, Pollock J, Sigler JJ, Tomaschko M, Tran E, Yue C, Kinsella TM, Molina-Arcas M, Cook BN, Simon GM, Weinstein DS, Downward J, Patricelli MP.
Klebba JE, et al. Among authors: liu y.
Science. 2025 Nov 13;390(6774):702-709. doi: 10.1126/science.adv2684. Epub 2025 Oct 9.
Science. 2025.
PMID: 41066541
Free PMC article.