Young-Sciame R[au] - Search Results

Year	Number of Results
1992	1
1993	1
1994	1
1995	2
1996	1
2007	1
2009	1
2016	1
2022	1
2023	0

1

Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.

Shvartsbart A, Roach JJ, Witten MR, Koblish H, Harris JJ, Covington M, Hess R, Lin L, Frascella M, Truong L, Leffet L, Conlen P, Beshad E, Klabe R, Katiyar K, Kaldon L, Young-Sciame R, He X, Petusky S, Chen KJ, Horsey A, Lei HT, Epling LB, Deller MC, Vechorkin O, Yao W. Shvartsbart A, et al. Among authors: young sciame r. J Med Chem. 2022 Nov 24;65(22):15433-15442. doi: 10.1021/acs.jmedchem.2c01366. Epub 2022 Nov 10. J Med Chem. 2022. PMID: 36356320

2

Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans.

Boer J, Young-Sciame R, Lee F, Bowman KJ, Yang X, Shi JG, Nedza FM, Frietze W, Galya L, Combs AP, Yeleswaram S, Diamond S. Boer J, et al. Among authors: young sciame r. Drug Metab Dispos. 2016 Oct;44(10):1668-74. doi: 10.1124/dmd.116.070680. Epub 2016 Jul 25. Drug Metab Dispos. 2016. PMID: 27457784

3

Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.

Kaila N, Janz K, DeBernardo S, Bedard PW, Camphausen RT, Tam S, Tsao DH, Keith JC Jr, Nickerson-Nutter C, Shilling A, Young-Sciame R, Wang Q. Kaila N, et al. Among authors: young sciame r. J Med Chem. 2007 Jan 11;50(1):21-39. doi: 10.1021/jm0602256. J Med Chem. 2007. PMID: 17201408

4

Desvenlafaxine and venlafaxine exert minimal in vitro inhibition of human cytochrome P450 and P-glycoprotein activities.

Oganesian A, Shilling AD, Young-Sciame R, Tran J, Watanyar A, Azam F, Kao J, Leung L. Oganesian A, et al. Among authors: young sciame r. Psychopharmacol Bull. 2009;42(2):47-63. Psychopharmacol Bull. 2009. PMID: 19629022

5

Formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts in the reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with DNA.

Wang M, Young-Sciame R, Chung FL, Hecht SS. Wang M, et al. Among authors: young sciame r. Chem Res Toxicol. 1995 Jun;8(4):617-24. doi: 10.1021/tx00046a017. Chem Res Toxicol. 1995. PMID: 7548743

6

Reactions of alpha-acetoxy-N-nitrosopyrrolidine and alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: formation of N2-tetrahydrofuranyl and N2-tetrahydropyranyl adducts.

Young-Sciame R, Wang M, Chung FL, Hecht SS. Young-Sciame R, et al. Chem Res Toxicol. 1995 Jun;8(4):607-16. doi: 10.1021/tx00046a016. Chem Res Toxicol. 1995. PMID: 7548742

7

A 32P-postlabeling method for simultaneous detection and quantification of exocyclic etheno and propano adducts in DNA.

Nath RG, Chen HJ, Nishikawa A, Young-Sciame R, Chung FL. Nath RG, et al. Among authors: young sciame r. Carcinogenesis. 1994 May;15(5):979-84. doi: 10.1093/carcin/15.5.979. Carcinogenesis. 1994. PMID: 8200104

8

Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct.

Hecht SS, Young-Sciame R, Chung FL. Hecht SS, et al. Among authors: young sciame r. Chem Res Toxicol. 1992 Sep-Oct;5(5):706-12. doi: 10.1021/tx00029a018. Chem Res Toxicol. 1992. PMID: 1446012

9

Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.

Liu Z, Young-Sciame R, Hecht SS. Liu Z, et al. Among authors: young sciame r. Chem Res Toxicol. 1996 Jun;9(4):774-80. doi: 10.1021/tx950206r. Chem Res Toxicol. 1996. PMID: 8831822

10

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.

Alworth WL, Young-Sciame R, Hecht SS. Alworth WL, et al. Among authors: young sciame r. Carcinogenesis. 1993 Aug;14(8):1711-3. doi: 10.1093/carcin/14.8.1711. Carcinogenesis. 1993. PMID: 8353857

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