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Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization.
Yount KS, Hall JM, Caution K, Shamseldin MM, Guo M, Marion K, Fullen AR, Huang Y, Maynard JA, Quataert SA, Deora R, Dubey P. Yount KS, et al. Front Immunol. 2023 May 18;14:1181876. doi: 10.3389/fimmu.2023.1181876. eCollection 2023. Front Immunol. 2023. PMID: 37275891 Free PMC article.
Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen.
Fullen AR, Gutierrez-Ferman JL, Yount KS, Love CF, Choi HG, Vargas MA, Raju D, Corps KN, Howell PL, Dubey P, Deora R. Fullen AR, et al. Among authors: yount ks. PLoS Pathog. 2022 Aug 15;18(8):e1010764. doi: 10.1371/journal.ppat.1010764. eCollection 2022 Aug. PLoS Pathog. 2022. PMID: 35969621 Free PMC article.
Whoop! There it is: The surprising resurgence of pertussis.
Fullen AR, Yount KS, Dubey P, Deora R. Fullen AR, et al. Among authors: yount ks. PLoS Pathog. 2020 Jul 23;16(7):e1008625. doi: 10.1371/journal.ppat.1008625. eCollection 2020 Jul. PLoS Pathog. 2020. PMID: 32702023 Free PMC article. No abstract available.
Chlamydia trachomatis induces low-frequency, sustained CD4 T cell responses in most women, predominantly targeting chlamydial protease-like activity factor, CPAF.
Li Y, Warren JA, Poston TB, Clutton G, Shaw FR, Conrad SZ, Xu Y, Zheng X, Yount KS, O'Connell CM, Wiesenfeld HC, Darville T, Goonetilleke N. Li Y, et al. Among authors: yount ks. J Infect Dis. 2024 Sep 9:jiae443. doi: 10.1093/infdis/jiae443. Online ahead of print. J Infect Dis. 2024. PMID: 39250505
Viral-vectored boosting of OmcB- or CPAF-specific T-cell responses fail to enhance protection from Chlamydia muridarum in infection-immune mice and elicits a non-protective CD8-dominant response in naïve mice.
Poston TB, Girardi J, Polson AG, Bhardwaj A, Yount KS, Jaras Salas I, Trim LK, Li Y, O'Connell CM, Leahy D, Harris JM, Beagley KW, Goonetilleke N, Darville T. Poston TB, et al. Among authors: yount ks. Mucosal Immunol. 2024 Oct;17(5):1005-1018. doi: 10.1016/j.mucimm.2024.06.012. Epub 2024 Jul 3. Mucosal Immunol. 2024. PMID: 38969067 Free PMC article.
Intranasal immunization with CPAF combined with ADU-S100 induces an effector CD4 T cell response and reduces bacterial burden following intravaginal infection with Chlamydia muridarum.
Poston TB, Girardi J, Kim M, Zwarycz P, Polson AG, Yount KS, Hanlan C, Jaras Salas I, Lammert SM, Arroyo D, Bruno T, Wu M, Rozzelle J, Fairman J, Esser-Kahn AP, Darville T. Poston TB, et al. Among authors: yount ks. Vaccine. 2024 Nov 12;43(Pt 1):126526. doi: 10.1016/j.vaccine.2024.126526. Online ahead of print. Vaccine. 2024. PMID: 39536454 Free article.
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