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Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
GBD 2023 Disease and Injury and Risk Factor Collaborators. GBD 2023 Disease and Injury and Risk Factor Collaborators. Lancet. 2025 Oct 18;406(10513):1873-1922. doi: 10.1016/S0140-6736(25)01637-X. Epub 2025 Oct 12. Lancet. 2025. PMID: 41092926 Free PMC article.
Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library.
Nemati F, Bischoff-Kont I, Salehi P, Nejad-Ebrahimi S, Mohebbi M, Bararjanian M, Hadian N, Hassanpour Z, Jung Y, Schaerlaekens S, Lucena-Agell D, Oliva MA, Fürst R, Nasiri HR. Nemati F, et al. Bioorg Chem. 2021 Oct;115:105135. doi: 10.1016/j.bioorg.2021.105135. Epub 2021 Jun 30. Bioorg Chem. 2021. PMID: 34303039
The so generated library, consisting of fifty-seven derivatives of the natural product noscapine, was tested against MDA-MB-231 breast cancer cells in a cellular proliferation assay (with a Z' > 0.7). The screening resulted in the identification of two novel noscapine d …
The so generated library, consisting of fifty-seven derivatives of the natural product noscapine, was tested against MDA-MB-231 breast cance …
Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling.
Diener S, Schorpp K, Strom TM, Hadian K, Lorenz-Depiereux B. Diener S, et al. Assay Drug Dev Technol. 2015 Oct;13(8):476-87. doi: 10.1089/adt.2015.653. Assay Drug Dev Technol. 2015. PMID: 26461432
This cell-based assay was highly robust (Z' factor >0.5) and the induction of the system is strictly dependent on the presence of FGF23. ...
This cell-based assay was highly robust (Z' factor >0.5) and the induction of the system is strictly dependent on the presence of …
19 results