Design, Synthesis, and Biological Evaluation of a Novel Series of Thiazolidinediones as Dual GSK-3ß and Tau Aggregation Inhibitors.
Abdollahi Z, Abnous K, Kalani MR, Taghdisi SM, Soltani S, Nejabat M, Hadizadeh F.
Abdollahi Z, et al.
Med Chem. 2025 Apr 30. doi: 10.2174/0115734064369119250413021648. Online ahead of print.
Med Chem. 2025.
PMID: 40325541
The inhibitory activities of the compounds 5a-p, against GSK-3ss were evaluated using Z'-LYTE technique, and the IC50 values were determined. RESULTS: Compound 5l (R1 = Me, R2 = 4-F-benzyl, R3 = butyl) with IC50 of 16.1 muM exhibited the most potent inhibition. ...
The inhibitory activities of the compounds 5a-p, against GSK-3ss were evaluated using Z'-LYTE technique, and the IC50 values were det …