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Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates.
Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA. Mallya M, et al. J Med Chem. 2007 Nov 1;50(22):5357-63. doi: 10.1021/jm070687z. Epub 2007 Oct 5. J Med Chem. 2007. PMID: 17918823 Free PMC article.
The best antagonists were effective at ratios of compound to Z alpha1-antitrypsin of 2.5:1 and reduced the intracellular accumulation of Z alpha1-antitrypsin by 70% in a cell model of disease. Identifying small molecules provides a novel therapy for the treatment of …
The best antagonists were effective at ratios of compound to Z alpha1-antitrypsin of 2.5:1 and reduced the intracellular accumulation …
The Resistance Training Effects on Skeletal Muscle Stem Cells in Older Adult: A Systematic Review and Meta-Analysis.
Heidari D, Shirvani H, Bazgir B, Shamsoddini A. Heidari D, et al. Cell J. 2023 Aug 1;25(8):513-523. doi: 10.22074/cellj.2023.1986679.1206. Cell J. 2023. PMID: 37641413 Free PMC article.
The meta-analysis found a significant effect of resistance training (RT) on muscle stem cells in the elderly (difference in means=-0.008, Z=-3.415, P=0.001). Also, muscle stem cells changes were similar in men and women (difference in means=-0.004, Z=-1.558, P=0.119 …
The meta-analysis found a significant effect of resistance training (RT) on muscle stem cells in the elderly (difference in means=-0.008, …
Bentonite addition to a PCB-contaminated sandy soil improved the growth and phytoremediation efficiency of Zea mays L. and Alternanthera sessilis L.
Salimizadeh M, Shirvani M, Shariatmadari H, Mortazavi MS. Salimizadeh M, et al. Int J Phytoremediation. 2020;22(2):176-183. doi: 10.1080/15226514.2019.1652564. Epub 2019 Aug 19. Int J Phytoremediation. 2020. PMID: 31424289

The average reductions in the PCB(i) due to Z. mays or A. sessilis cultivations were 34.3 and 21.4%, respectively, depending on initial soil PCB(i) loading and plant growth period. Moreover, addition of bentonite led to significant (p < 0.05) enhancements in plant growt

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The average reductions in the PCB(i) due to Z. mays or A. sessilis cultivations were 34.3 and 21.4%, respectively, depending on initi …