Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis.
Smarr B, Cutler T, Loh DH, Kudo T, Kuljis D, Kriegsfeld L, Ghiani CA, Colwell CS.
Smarr B, et al.
J Neurosci Res. 2019 Dec;97(12):1606-1623. doi: 10.1002/jnr.24505. Epub 2019 Jul 29.
J Neurosci Res. 2019.
PMID: 31359503
Free PMC article.
The underlying mechanisms, including the possible role of the circadian timing system, have been the topic of a number of recent studies. The (z)Q175 mouse is a knock-in model in which the human exon 1 sequence of the huntingtin gene is inserted into the mouse DNA with app …
The underlying mechanisms, including the possible role of the circadian timing system, have been the topic of a number of recent studies. Th …