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Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy.
Pfau M, Schmitz-Valckenberg S, Ribeiro R, Safaei R, McKeown A, Fleckenstein M, Holz FG. Pfau M, et al. Sci Rep. 2022 Oct 25;12(1):17870. doi: 10.1038/s41598-022-22404-9. Sci Rep. 2022. PMID: 36284220 Free PMC article. Clinical Trial.

Participants treated with pegcetacoplan monthly had a thicker ONL along the 5.16 contour-line compared to the pooled sham arm (mean difference [95% CI] + 0.29 z-score units [0.16, 0.42], P < 0.001). The same was evident for eyes treated with pegcetacoplan every other mo

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Participants treated with pegcetacoplan monthly had a thicker ONL along the 5.16 contour-line compared to the pooled sham arm (mean differen …
Design of a multi-epitope vaccine against SARS-CoV-2 using immunoinformatics approach.
Sanami S, Zandi M, Pourhossein B, Mobini GR, Safaei M, Abed A, Arvejeh PM, Chermahini FA, Alizadeh M. Sanami S, et al. Int J Biol Macromol. 2020 Dec 1;164:871-883. doi: 10.1016/j.ijbiomac.2020.07.117. Epub 2020 Jul 15. Int J Biol Macromol. 2020. PMID: 32682041 Free PMC article.
The refinement process was performed to improve the quality of the 3D model structure; the validation process is performed using the Ramachandran plot and ProSA z-score. The proposed vaccine's binding affinity to the HLA-A11:01 and HLA-DRB1_01:01 molecule was evaluated by …
The refinement process was performed to improve the quality of the 3D model structure; the validation process is performed using the Ramacha …
Kinetics Analysis and Susceptibility Coefficient of the Pathogenic Bacteria by Titanium Dioxide and Zinc Oxide Nanoparticles.
Alizadeh-Sani M, Hamishehkar H, Khezerlou A, Maleki M, Azizi-Lalabadi M, Bagheri V, Safaei P, Azimi T, Hashemi M, Ehsani A. Alizadeh-Sani M, et al. Adv Pharm Bull. 2020 Jan;10(1):56-64. doi: 10.15171/apb.2020.007. Epub 2019 Dec 11. Adv Pharm Bull. 2020. PMID: 32002362 Free PMC article.
Results: The results of this study revealed that, the highest susceptibility was observed for L. monocytogenes (Z=0.025 mL/mug) to TiO(2) NPs, whereas the lowest susceptibility was obtained in the reaction of ZnO NPs with S. enteritidis (Z=0.0033 mL/mug). ...
Results: The results of this study revealed that, the highest susceptibility was observed for L. monocytogenes (Z=0.025 mL/mug) to Ti …
A meta-analysis and trial sequential analysis of serum copeptin level in adult patients with Obstructive Sleep Apnoea Syndrome.
Golshah A, Marjani K, Mozaffari HR, Nikkerdar N, Safaei M, Moradpoor H, Sharifi R, Sadeghi M. Golshah A, et al. Int Orthod. 2021 Sep;19(3):346-352. doi: 10.1016/j.ortho.2021.06.005. Epub 2021 Jul 23. Int Orthod. 2021. PMID: 34305013
To report the serum copeptin level in OSAS patients compared to controls, the pooled OR became 12.21pg/mL (95%CI: 2.31 to 22.11; P=0.02) and also the pooled OR for comparison of serum copeptin level in severe versus moderate/mild OSAS patients was 5.96pg/mL (95%CI: 1.46 to 10.47; …
To report the serum copeptin level in OSAS patients compared to controls, the pooled OR became 12.21pg/mL (95%CI: 2.31 to 22.11; P=0.02) and …
Hypnotic effect of Coriandrum sativum, Ziziphus jujuba, Lavandula angustifolia and Melissa officinalis extracts in mice.
Hajhashemi V, Safaei A. Hajhashemi V, et al. Res Pharm Sci. 2015 Nov-Dec;10(6):477-84. Res Pharm Sci. 2015. PMID: 26779267 Free PMC article.
Three doses of the extracts (250, 500 and 1000 mg/kg of C. sativum and Z. jujuba and 200, 400 and 800 mg/kg of L. angustifolia and M. officinalis) were orally administered to male Swiss mice (20-25 g) and one hour later pentobarbital (50 mg/kg, i.p.) was injected to induce …
Three doses of the extracts (250, 500 and 1000 mg/kg of C. sativum and Z. jujuba and 200, 400 and 800 mg/kg of L. angustifolia and M. …