Multiple functions of microfluidic platforms: Characterization and applications in tissue engineering and diagnosis of cancer

Soodabeh Davaran; Mohammad Sadeghinia; Zahra Jamalpoor; Vahideh Raeisdasteh Hokmabad; Mehdi Doosti-Telgerd; Ansar Karimian; Zahra Sadeghinia; Javad Khalilifard; Akram Keramt; Farzad Moradikhah; Ali Sadeghinia

doi:10.1002/elps.201900341

Multiple functions of microfluidic platforms: Characterization and applications in tissue engineering and diagnosis of cancer

Electrophoresis. 2020 Jun;41(12):1081-1094. doi: 10.1002/elps.201900341. Epub 2020 Mar 12.

Authors

Soodabeh Davaran^{1

2}, Mohammad Sadeghinia³, Zahra Jamalpoor⁴, Vahideh Raeisdasteh Hokmabad⁵, Mehdi Doosti-Telgerd⁶, Ansar Karimian⁷, Zahra Sadeghinia⁸, Javad Khalilifard⁹, Akram Keramt^{1

2}, Farzad Moradikhah¹⁰, Ali Sadeghinia^{1

2

5

11}

Affiliations

¹ Department of Pharmaceutical Chemistry, Faculty of pharmacy, Tabriz University of Medical Science, Tabriz, Iran.
² Drug Applied Research Center, Tabriz University of Medical Science, Tabriz, Iran.
³ School of Chemistry, University College of Science, University of Tehran, Tehran, Iran.
⁴ Trauma Research Center, Aja University of Medical Science, Tehran, Iran.
⁵ Drug Applied Research Center and Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
⁸ Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
⁹ Hepatitis Research Center, Lorestan University of Medical Sciences, Kohorramabad, Iran.
¹⁰ Department of Biomedical Engineering, Amirkabir, University of Technology, Tehran, Iran.
¹¹ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 32103511
DOI: 10.1002/elps.201900341

Abstract

Microfluidic system, or lab-on-a-chip, has grown explosively. This system has been used in research for the first time and then entered in the clinical section. Due to economic reasons, this technique has been used for screening of laboratory and clinical indices. The microfluidic system solves some difficulties accompanied by clinical and biological applications. In this review, the interpretation and analysis of some recent developments in microfluidic systems in biomedical applications with more emphasis on tissue engineering and cancer will be discussed. Moreover, we try to discuss the features and functions of microfluidic systems.

Keywords: cancer; lab-on-a-chip; microfluidics; tissue engineering.

Publication types

Review

MeSH terms

Animals
Equipment Design
Humans
Lab-On-A-Chip Devices*
Mice
Microfluidic Analytical Techniques*
Neoplasms / diagnosis*
Tissue Engineering*
Tissue Scaffolds