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Page 1
SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species.
bioRxiv [Preprint]. 2023 Mar 29:2023.03.28.534654. doi: 10.1101/2023.03.28.534654.
bioRxiv. 2023.
PMID: 37034617
Free PMC article.
Preprint.
Correction: Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation.
Wu K, Yee NA, Srinivasan S, Mahmoodi A, Zakharian M, Mejia Oneto JM, Royzen M.
Wu K, et al. Among authors: zakharian m.
Chem Sci. 2021 May 21;12(21):7583. doi: 10.1039/d1sc90098f.
Chem Sci. 2021.
PMID: 34165452
Free PMC article.
Item in Clipboard
Cancer Cell-Derived, Drug-Loaded Nanovesicles Induced by Sulfhydryl-Blocking for Effective and Safe Cancer Therapy.
Ingato D, Edson JA, Zakharian M, Kwon YJ.
Ingato D, et al. Among authors: zakharian m.
ACS Nano. 2018 Sep 25;12(9):9568-9577. doi: 10.1021/acsnano.8b05377. Epub 2018 Aug 24.
ACS Nano. 2018.
PMID: 30130093
Item in Clipboard
SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions.
Srinivasan S, Yee NA, Wu K, Zakharian M, Mahmoodi A, Royzen M, Oneto JMM.
Srinivasan S, et al. Among authors: zakharian m.
Adv Ther (Weinh). 2021 Mar;4(3):2000243. doi: 10.1002/adtp.202000243. Epub 2021 Jan 20.
Adv Ther (Weinh). 2021.
PMID: 33869738
Free PMC article.
Item in Clipboard
Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation.
Wu K, Yee NA, Srinivasan S, Mahmoodi A, Zakharian M, Mejia Oneto JM, Royzen M.
Wu K, et al. Among authors: zakharian m.
Chem Sci. 2021 Jan 5;12(4):1259-1271. doi: 10.1039/d0sc06099b.
Chem Sci. 2021.
PMID: 34163888
Free PMC article.
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