Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2011 1
2013 1
2014 1
2015 1
2017 3
2018 1
2019 3
2020 4
2021 3
2022 5
2023 1
2024 9
2025 3

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

33 results

Results by year

Filters applied: . Clear all
Page 1
DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis.
Le X, Mu J, Peng W, Tang J, Xiang Q, Tian S, Feng Y, He S, Qiu Z, Ren G, Huang A, Lin Y, Tao Q, Xiang T. Le X, et al. Theranostics. 2020 Jul 25;10(21):9495-9511. doi: 10.7150/thno.45631. eCollection 2020. Theranostics. 2020. PMID: 32863941 Free PMC article.
ZDHHC1's salient anti-tumor abilities were recognized in vivo as well. Metabolomic and proteomic analyses predicted inhibitory role of ZDHHC1 in glucose metabolism pathways in a CYGB-dependent manner, and in pentose phosphate pathway (PPP), which was validated by ex …
ZDHHC1's salient anti-tumor abilities were recognized in vivo as well. Metabolomic and proteomic analyses predicted inhibitory role o …
ZDHHC1 downregulates LIPG and inhibits colorectal cancer growth via IGF2BP1 Palmitoylation.
Zhang Q, Du Z, Zhou W, Li W, Yang Q, Yu H, Liu T. Zhang Q, et al. Cancer Gene Ther. 2024 Sep;31(9):1427-1437. doi: 10.1038/s41417-024-00808-1. Epub 2024 Jul 28. Cancer Gene Ther. 2024. PMID: 39069526 Free PMC article.
However, our knowledge of the functional roles of ZDHHC1 in CRC is limited. We discovered that ZDHHC1 expression was downregulated in CRC tissues and that low levels of ZDHHC1 were associated with unfavorable prognosis. Functional studies showed that ZDHHC …
However, our knowledge of the functional roles of ZDHHC1 in CRC is limited. We discovered that ZDHHC1 expression was downregul …
Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity.
Chen W, Guo L, Wei W, Cai C, Wu G. Chen W, et al. Cell Rep. 2024 Sep 17;43(9):114762. doi: 10.1016/j.celrep.2024.114762. Print 2024 Sep 24. Cell Rep. 2024. PMID: 39321020 Free article.
Mechanistically, Gpm6a regulates Procr protein stability by mediating the formation of lipid rafts, a process requiring Zdhhc1 and Zdhhc2 to palmitate Gpm6a at Cys(17,18) and Cys(246) sites. Our findings highlight an important mechanism involving Zdhhc1- and Zdhhc2- …
Mechanistically, Gpm6a regulates Procr protein stability by mediating the formation of lipid rafts, a process requiring Zdhhc1 and Zd …
Zdhhc1 deficiency mitigates foam cell formation and atherosclerosis by inhibiting PI3K-Akt-mTOR signaling pathway through facilitating the nuclear translocation of p110alpha.
Zhou B, Liu Y, Ma H, Zhang B, Lu B, Li S, Liu T, Qi Y, Wang Y, Zhang M, Qiu J, Fu R, Li W, Lu L, Tian S, Liu Q, Gu Y, Huang R, Lawrence T, Kong E, Zhang L, Li T, Liang Y. Zhou B, et al. Biochim Biophys Acta Mol Basis Dis. 2025 Feb;1871(2):167577. doi: 10.1016/j.bbadis.2024.167577. Epub 2024 Nov 19. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 39566590
In this study, we discovered that the knockout of zDHHC1 in THP-1 cells, as well as Zdhhc1 in mice, markedly reduces the uptake of oxidized low-density lipoprotein (ox-LDL) by macrophages, thereby inhibiting foam cell formation. ...Consistent with this, we observed …
In this study, we discovered that the knockout of zDHHC1 in THP-1 cells, as well as Zdhhc1 in mice, markedly reduces the uptak …
p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication.
Wang X, Wu Z, Li Y, Yang Y, Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B, Ma Z. Wang X, et al. PLoS Pathog. 2020 Oct 27;16(10):e1009035. doi: 10.1371/journal.ppat.1009035. eCollection 2020 Oct. PLoS Pathog. 2020. Retraction in: PLoS Pathog. 2024 Nov 8;20(11):e1012698. doi: 10.1371/journal.ppat.1012698. PMID: 33108395 Free PMC article. Retracted.
Screening of palmitoyltransferases revealed that zinc finger DHHC domain-containing protein 1 (ZDHHC1) was transcriptionally up-regulated by p53, and consequently ZDHHC1 interacted with IFITM3 to promote its palmitoylation and stability. Knockdown of IFITM3 signific …
Screening of palmitoyltransferases revealed that zinc finger DHHC domain-containing protein 1 (ZDHHC1) was transcriptionally up-regul …
Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation.
Nie L, Fei C, Fan Y, Dang F, Zhao Z, Zhu T, Wu X, Dai T, Balasubramanian A, Pan J, Hu Y, Luo HR, Wei W, Chen J. Nie L, et al. Mol Cell. 2024 Sep 5;84(17):3336-3353.e7. doi: 10.1016/j.molcel.2024.08.001. Epub 2024 Aug 21. Mol Cell. 2024. PMID: 39173637
Specifically, NLRP3 undergoes palmitoylation at two sites by palmitoyl transferase zDHHC1, facilitating its trafficking between subcellular membranes, including the mitochondria, trans-Golgi network (TGN), and endosome. This dynamic trafficking culminates in the localizati …
Specifically, NLRP3 undergoes palmitoylation at two sites by palmitoyl transferase zDHHC1, facilitating its trafficking between subce …
Identification of ZDHHC1 as a Pyroptosis Inducer and Potential Target in the Establishment of Pyroptosis-Related Signature in Localized Prostate Cancer.
Luo CG, Gui CP, Huang GW, Chen JL, Li JY, Li PJ, Xu QH, Wang YH, Zhu JQ, Liang H, Wang Z, Deng Q, Cao JZ, Luo JH, Lu J, Chen W. Luo CG, et al. Oxid Med Cell Longev. 2022 Dec 22;2022:5925817. doi: 10.1155/2022/5925817. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36589680 Free PMC article.
Additionally, after evaluating the six genes in the model, ZDHHC1 was found to be an important component. Its antitumor role was further assessed through in vivo and in vitro experiments, and its promoting effect on pyroptosis was further evaluated and verified. ...
Additionally, after evaluating the six genes in the model, ZDHHC1 was found to be an important component. Its antitumor role was furt …
Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation.
Tang J, Peng W, Feng Y, Le X, Wang K, Xiang Q, Li L, Wang Y, Xu C, Mu J, Xu K, Ji P, Tao Q, Huang A, Deng CX, Lin Y, Xiang T. Tang J, et al. Oncogene. 2021 Sep;40(35):5416-5426. doi: 10.1038/s41388-021-01949-5. Epub 2021 Jul 19. Oncogene. 2021. PMID: 34282274 Free PMC article.
The protein product of ZDHHC1 is an S-palmitoyltransferase and we have identified p53 as a substrate for ZDHHC1-mediated palmitoylation, specifically at the C135, C176, and C275 residues. The novel form of post-translational modification of p53 is required for the n …
The protein product of ZDHHC1 is an S-palmitoyltransferase and we have identified p53 as a substrate for ZDHHC1-mediated palmi …
Molecular and functional characterization of zinc finger aspartate-histidine-histidine-cysteine (DHHC)-type containing 1, ZDHHC1 in Chinese perch Siniperca chuatsi.
Chen SN, Zhang S, Li L, Laghari ZA, Nie P. Chen SN, et al. Fish Shellfish Immunol. 2022 Nov;130:215-222. doi: 10.1016/j.fsi.2022.09.023. Epub 2022 Sep 16. Fish Shellfish Immunol. 2022. PMID: 36122636
The ZDHHC1 has five putative transmembrane motifs and conserved DHHC domain, showing high amino-acid identity with other teleost fish, and vertebrate ZDHHC1 loci are conserved from fish to human. ...It is further observed that ZDHHC1 interacts with MITA and t …
The ZDHHC1 has five putative transmembrane motifs and conserved DHHC domain, showing high amino-acid identity with other teleost fish …
33 results