Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.
Hackstein CP, Spitzer J, Symeonidis K, Horvatic H, Bedke T, Steglich B, Klein S, Assmus LM, Odainic A, Szlapa J, Kessler N, Beyer M, Schmithausen R, Latz E, Flavell RA, Garbi N, Kurts C, Kümmerer BM, Trebicka J, Roers A, Huber S, Schmidt SV, Knolle PA, Abdullah Z.
Hackstein CP, et al.
J Hepatol. 2023 Jul;79(1):150-166. doi: 10.1016/j.jhep.2023.02.026. Epub 2023 Mar 2.
J Hepatol. 2023.
PMID: 36870611
Free article.
RESULTS: We demonstrate that BDL- and CCL(4)-induced prolonged liver injury leads to impaired T-cell responses to vaccination and viral infection in mice, subsequently leading to persistent infection. We observed a similarly defective T-cell response to vaccination in pati …
RESULTS: We demonstrate that BDL- and CCL(4)-induced prolonged liver injury leads to impaired T-cell responses to vaccination and viral infe …