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High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models.
Hop CE, Cole MJ, Davidson RE, Duignan DB, Federico J, Janiszewski JS, Jenkins K, Krueger S, Lebowitz R, Liston TE, Mitchell W, Snyder M, Steyn SJ, Soglia JR, Taylor C, Troutman MD, Umland J, West M, Whalen KM, Zelesky V, Zhao SX. Hop CE, et al. Among authors: zelesky v. Curr Drug Metab. 2008 Nov;9(9):847-53. doi: 10.2174/138920008786485092. Curr Drug Metab. 2008. PMID: 18991580 Review.
The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B. Zhou L, et al. Among authors: zelesky v. Drug Metab Dispos. 2009 May;37(5):946-55. doi: 10.1124/dmd.108.024489. Epub 2009 Feb 18. Drug Metab Dispos. 2009. PMID: 19225039