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Molecular regulation of PPARgamma/RXRalpha signaling by the novel cofactor ZFP407.
Charrier A, Ockunzzi J, Main L, Ghanta SV, Buchner DA. Charrier A, et al. PLoS One. 2024 May 23;19(5):e0294003. doi: 10.1371/journal.pone.0294003. eCollection 2024. PLoS One. 2024. PMID: 38781157 Free PMC article.
Consistent with this observation, ZFP407 ChIP-seq peaks significantly overlapped with PPARgamma ChIP-seq peaks, with more than half of ZFP407 peaks overlapping with PPARgamma peaks. ...Site-directed mutagenesis of frequent PPARgamma phosphorylation or SUMOylation si …
Consistent with this observation, ZFP407 ChIP-seq peaks significantly overlapped with PPARgamma ChIP-seq peaks, with more than half o …
Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.
Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR. Buchner DA, et al. J Biol Chem. 2015 Mar 6;290(10):6376-86. doi: 10.1074/jbc.M114.623736. Epub 2015 Jan 16. J Biol Chem. 2015. PMID: 25596527 Free PMC article.
However, ZFP407 and PPARgamma co-overexpression synergistically activated a PPARgamma reporter construct beyond the level of PPARgamma alone. Thus, ZFP407 may represent a new modulator of the PPARgamma signaling pathway....
However, ZFP407 and PPARgamma co-overexpression synergistically activated a PPARgamma reporter construct beyond the level of PPARgamm …
Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice.
Charrier A, Xu X, Guan BJ, Ngo J, Wynshaw-Boris A, Hatzoglou M, Buchner DA. Charrier A, et al. Mol Cell Endocrinol. 2021 Feb 5;521:111109. doi: 10.1016/j.mce.2020.111109. Epub 2020 Dec 4. Mol Cell Endocrinol. 2021. PMID: 33285243 Free PMC article.
The in vivo physiological role of ZFP407 in mature adipocytes, however, remains to be elucidated. Here we generated adipocyte-specific ZFP407 knockout (AZKO) mice and discovered a partial lipodystrophic phenotype with reduced fat mass, hypertrophic adipocytes in ing …
The in vivo physiological role of ZFP407 in mature adipocytes, however, remains to be elucidated. Here we generated adipocyte-specifi …
Connecting homocysteine and obesity through pyroptosis, gut microbiome, epigenetics, peroxisome proliferator-activated receptor γ, and zinc finger protein 407.
Laha A, Majumder A, Singh M, Tyagi SC. Laha A, et al. Can J Physiol Pharmacol. 2018 Oct;96(10):971-976. doi: 10.1139/cjpp-2018-0037. Epub 2018 Jun 11. Can J Physiol Pharmacol. 2018. PMID: 29890083 Review.
It has been known for a while that PPARgamma dysregulation results in various metabolic disorders including glucose and lipid metabolism. Recently, zinc finger protein 407 (Zfp407) is reported to regulate PPARgamma target gene expression without affecting PPARgamma transcr …
It has been known for a while that PPARgamma dysregulation results in various metabolic disorders including glucose and lipid metabolism. Re …
Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice.
Charrier A, Wang L, Stephenson EJ, Ghanta SV, Ko CW, Croniger CM, Bridges D, Buchner DA. Charrier A, et al. Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E869-E880. doi: 10.1152/ajpendo.00234.2016. Epub 2016 Sep 13. Am J Physiol Endocrinol Metab. 2016. PMID: 27624101 Free PMC article.
The increased PPAR activity was not associated with increased PPAR mRNA or protein levels, suggesting that Zfp407 posttranslationally regulates PPAR activity. Collectively, these results demonstrate that Zfp407 overexpression improved glucose homeostasis. Thus, Z …
The increased PPAR activity was not associated with increased PPAR mRNA or protein levels, suggesting that Zfp407 posttranslationally …