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Page 1
Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H. Nakasuji T, et al. PLoS Genet. 2017 Jan 23;13(1):e1006578. doi: 10.1371/journal.pgen.1006578. eCollection 2017 Jan. PLoS Genet. 2017. PMID: 28114340 Free PMC article.
Here, we adopted the highly efficient CRISPR/Cas9 system to generate individual Zfy1 or Zfy2 knockout (KO) mice and Zfy1 and Zfy2 double knockout (Zfy1/2-DKO) mice. While individual Zfy1 or Zfy2-KO mice did not show any significant phenotypic alteratio …
Here, we adopted the highly efficient CRISPR/Cas9 system to generate individual Zfy1 or Zfy2 knockout (KO) mice and Zfy1 and Z …
Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
Yamauchi Y, Matsumura T, Bakse J, Holmlund H, Blanchet G, Carrot E, Ikawa M, Ward MA. Yamauchi Y, et al. Biol Reprod. 2022 Jun 13;106(6):1312-1326. doi: 10.1093/biolre/ioac057. Biol Reprod. 2022. PMID: 35293998 Free PMC article.
Here, we used CRISPR/Cas9 to specifically remove open reading frame of Zfy1, Zfy2, or both Zfy1 and Zfy2, and generated Zfy knockout (KO) and double knockout (DKO) mice. ...The data also show that while the loss of Zfy1 is benign, the loss of Zfy2 is mildly d …
Here, we used CRISPR/Cas9 to specifically remove open reading frame of Zfy1, Zfy2, or both Zfy1 and Zfy2, and generated Zfy kn …
Characterization of the murine Zfy1 and Zfy2 promoters.
Zambrowicz BP, Findley SD, Simpson EM, Page DC, Palmiter RD. Zambrowicz BP, et al. Genomics. 1994 Nov 15;24(2):406-8. doi: 10.1006/geno.1994.1641. Genomics. 1994. PMID: 7698773 No abstract available.
Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Vernet N, et al. PLoS Genet. 2014 Jun 26;10(6):e1004444. doi: 10.1371/journal.pgen.1004444. eCollection 2014 Jun. PLoS Genet. 2014. PMID: 24967676 Free PMC article.
Mouse Zfy1 and Zfy2 encode zinc finger transcription factors that map to the short arm of the Y chromosome (Yp). ...The interphase transcription and meiosis II function of Zfx, Zfy1 and Zfy2 validate this hypothesis....
Mouse Zfy1 and Zfy2 encode zinc finger transcription factors that map to the short arm of the Y chromosome (Yp). ...The interphase tr …
Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.
Mahaffey CL, Bayleran JK, Yeh GY, Lee TC, Page DC, Simpson EM. Mahaffey CL, et al. Genomics. 1997 Apr 1;41(1):123-7. doi: 10.1006/geno.1997.4611. Genomics. 1997. PMID: 9126493
We show that Zfy1 has 11 exons distributed across at least 56 kb, and Zfy2 has a minimum of 9 exons distributed across at least 52 kb. ...Zfy1 and Zfy2 are homologous to other ZFY family members within the coding region, but the untranslated regions show no sequence …
We show that Zfy1 has 11 exons distributed across at least 56 kb, and Zfy2 has a minimum of 9 exons distributed across at least 52 kb …
Molecular cloning of a cold-shock domain protein, zfY1, in zebrafish embryo(1).
Chang BE, Lin CY, Kuo CM. Chang BE, et al. Biochim Biophys Acta. 1999 Aug 17;1433(1-2):343-9. doi: 10.1016/s0167-4838(99)00142-9. Biochim Biophys Acta. 1999. PMID: 10446383
Determined from the deduced amino acid sequence, this protein is most similar to Xenopus, FRGY1, and this newly cloned zebrafish gene was therefore designated as zfY1....
Determined from the deduced amino acid sequence, this protein is most similar to Xenopus, FRGY1, and this newly cloned zebrafish gene was th …
Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.
Holmlund H, Yamauchi Y, Ruthig VA, Cocquet J, Ward MA. Holmlund H, et al. Mol Hum Reprod. 2023 Jul 31;29(8):gaad025. doi: 10.1093/molehr/gaad025. Mol Hum Reprod. 2023. PMID: 37354519 Free PMC article.
The initial studies of the mouse homologues, Zfy1 and Zfy2, were performed using mice with spontaneous Y chromosome mutations and Zfy transgenes. ...This knowledge reinforces the importance of these factors for mouse spermatogenesis and informs our understanding of the hum …
The initial studies of the mouse homologues, Zfy1 and Zfy2, were performed using mice with spontaneous Y chromosome mutations and Zfy …
Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development.
Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Vernet N, et al. PLoS One. 2016 Jan 14;11(1):e0145398. doi: 10.1371/journal.pone.0145398. eCollection 2016. PLoS One. 2016. PMID: 26765744 Free PMC article.
Using mouse models lacking a Y chromosome but with varying Yp gene complements provided by Yp chromosomal derivatives or transgenes, we recently identified the Y-encoded zinc finger transcription factors Zfy1 and Zfy2 as the Yp genes promoting the second meiotic division. …
Using mouse models lacking a Y chromosome but with varying Yp gene complements provided by Yp chromosomal derivatives or transgenes, we rece …
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Decarpentrie F, et al. Hum Mol Genet. 2012 Jun 15;21(12):2631-45. doi: 10.1093/hmg/dds088. Epub 2012 Mar 9. Hum Mol Genet. 2012. PMID: 22407129 Free PMC article.
Recently, we have shown that mouse Zfy2, but not Zfy1, is involved in triggering the apoptotic elimination of specific types of sex chromosomally aberrant spermatocytes. ...In mice, we define a variety of Zfy transcripts, among which is a Zfy2 transcript that predominates …
Recently, we have shown that mouse Zfy2, but not Zfy1, is involved in triggering the apoptotic elimination of specific types of sex c …
45 results