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Page 1
Systematic identification of Y-chromosome gene functions in mouse spermatogenesis.
Subrini J, Varsally W, Balsells IB, Bensberg M, Sioutas G, Ojarikre O, Maciulyte V, Gylemo B, Crawley K, Courtis K, de Rooij DG, Turner JMA. Subrini J, et al. Science. 2025 Jan 24;387(6732):393-400. doi: 10.1126/science.ads6495. Epub 2025 Jan 23. Science. 2025. PMID: 39847625 Free PMC article.
We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y, Uty, and Zfy2 deletants, spermatogenesis was impaired. We found that Uty regulates spermatogonial proliferation, revealed a role for Zfy2 in promoting meiotic sex chromosome pairing, and uncover …
We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y, Uty, and Zfy2 deletants, spermatogenesis was impaired. We fou …
Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility.
Yamauchi Y, Matsumura T, Bakse J, Holmlund H, Blanchet G, Carrot E, Ikawa M, Ward MA. Yamauchi Y, et al. Biol Reprod. 2022 Jun 13;106(6):1312-1326. doi: 10.1093/biolre/ioac057. Biol Reprod. 2022. PMID: 35293998 Free PMC article.
Here, we used CRISPR/Cas9 to specifically remove open reading frame of Zfy1, Zfy2, or both Zfy1 and Zfy2, and generated Zfy knockout (KO) and double knockout (DKO) mice. ...The data also show that while the loss of Zfy1 is benign, the loss of Zfy2 is mildly d …
Here, we used CRISPR/Cas9 to specifically remove open reading frame of Zfy1, Zfy2, or both Zfy1 and Zfy2, and generated Zfy kn …
Complementary Critical Functions of Zfy1 and Zfy2 in Mouse Spermatogenesis and Reproduction.
Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H. Nakasuji T, et al. PLoS Genet. 2017 Jan 23;13(1):e1006578. doi: 10.1371/journal.pgen.1006578. eCollection 2017 Jan. PLoS Genet. 2017. PMID: 28114340 Free PMC article.
Here, we adopted the highly efficient CRISPR/Cas9 system to generate individual Zfy1 or Zfy2 knockout (KO) mice and Zfy1 and Zfy2 double knockout (Zfy1/2-DKO) mice. While individual Zfy1 or Zfy2-KO mice did not show any significant phenotypic alterations in f …
Here, we adopted the highly efficient CRISPR/Cas9 system to generate individual Zfy1 or Zfy2 knockout (KO) mice and Zfy1 and Zfy2 …
Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Formation and Function in Assisted Fertilization.
Yamauchi Y, Riel JM, Ruthig V, Ward MA. Yamauchi Y, et al. PLoS Genet. 2015 Dec 31;11(12):e1005476. doi: 10.1371/journal.pgen.1005476. eCollection 2015 Dec. PLoS Genet. 2015. PMID: 26719889 Free PMC article.
Using mouse models with abrogated Y chromosome gene complements and Y-derived transgene we identified Y chromosome encoded Zfy2 as the gene responsible for sperm formation and function. In the presence of a Zfy2 transgene, mice lacking the Y chromosome and transgeni …
Using mouse models with abrogated Y chromosome gene complements and Y-derived transgene we identified Y chromosome encoded Zfy2 as th …
Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells.
Holmlund H, Coulée M, Yamauchi Y, Yarbabaeva B, Tekayev M, Garcia IR, Feudjio OU, de la Iglesia A, Larcombe L, Ellis PJI, Cocquet J, Ward MA. Holmlund H, et al. Cell Death Differ. 2025 Aug 27. doi: 10.1038/s41418-025-01569-6. Online ahead of print. Cell Death Differ. 2025. PMID: 40866672
The mouse zinc finger genes Zfy1 and Zfy2 are essential for male fertility. Recently, we produced Zfy1 knock-out (KO), Zfy2 KO, and Zfy1/2 double-knock-out (Zfy DKO) mice, and found that Zfy DKO males were infertile. ...Significantly altered germ cell transcriptomes …
The mouse zinc finger genes Zfy1 and Zfy2 are essential for male fertility. Recently, we produced Zfy1 knock-out (KO), Zfy2 KO …
Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development.
Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Vernet N, et al. PLoS One. 2016 Jan 14;11(1):e0145398. doi: 10.1371/journal.pone.0145398. eCollection 2016. PLoS One. 2016. PMID: 26765744 Free PMC article.
The preferential involvement of Zfy2 is consistent with the presence of an additional strong spermatid-specific promotor that has been acquired by this gene. This is further supported by the fact that promotion of sperm morphogenesis is also seen in one of the two markedly …
The preferential involvement of Zfy2 is consistent with the presence of an additional strong spermatid-specific promotor that has bee …
The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility.
Vernet N, Szot M, Mahadevaiah SK, Ellis PJ, Decarpentrie F, Ojarikre OA, Rattigan Á, Taketo T, Burgoyne PS. Vernet N, et al. Development. 2014 Feb;141(4):855-66. doi: 10.1242/dev.091165. Development. 2014. PMID: 24496622 Free PMC article.
Transgenic addition of Yp genes to XO females implicated Zfy2 as being responsible for the deleterious Y chromosomal effect on fertility. Zfy2 transcript levels were reduced in ovaries of XY(d-1) compared with XY(Sry-) females in keeping with their differing fertili …
Transgenic addition of Yp genes to XO females implicated Zfy2 as being responsible for the deleterious Y chromosomal effect on fertil …
Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division.
Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Vernet N, et al. PLoS Genet. 2014 Jun 26;10(6):e1004444. doi: 10.1371/journal.pgen.1004444. eCollection 2014 Jun. PLoS Genet. 2014. PMID: 24967676 Free PMC article.
Mouse Zfy1 and Zfy2 encode zinc finger transcription factors that map to the short arm of the Y chromosome (Yp). ...The interphase transcription and meiosis II function of Zfx, Zfy1 and Zfy2 validate this hypothesis....
Mouse Zfy1 and Zfy2 encode zinc finger transcription factors that map to the short arm of the Y chromosome (Yp). ...The interphase tr …
Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential.
Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Decarpentrie F, et al. Hum Mol Genet. 2012 Jun 15;21(12):2631-45. doi: 10.1093/hmg/dds088. Epub 2012 Mar 9. Hum Mol Genet. 2012. PMID: 22407129 Free PMC article.
Mammalian ZFY genes are located on the Y chromosome, and code putative transcription factors with 12-13 zinc fingers preceded by a large acidic (activating) domain. In mice, there are two genes, Zfy1 and Zfy2, which are expressed mainly in the testis. Their transcription i …
Mammalian ZFY genes are located on the Y chromosome, and code putative transcription factors with 12-13 zinc fingers preceded by a large aci …
49 results