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135 results

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miR-20b-5p is a novel biomarker for detecting prostate cancer.
Zhai TY, Dou M, Ma YB, Wang H, Liu F, Zhang LD, Chong T, Wang ZM, Xue L. Zhai TY, et al. Oncol Lett. 2022 Oct 12;24(6):426. doi: 10.3892/ol.2022.13546. eCollection 2022 Dec. Oncol Lett. 2022. PMID: 36311688 Free PMC article.
The present study evaluated the diagnostic value of microRNA (miR)-20b-5p in PCa. Tissue miR-20b-5p expression levels and their correlation with clinical parameters were assessed using The Cancer Genome Atlas (TCGA) datasets, and the diagnostic value of the miR-2 …
The present study evaluated the diagnostic value of microRNA (miR)-20b-5p in PCa. Tissue miR-20b-5p expression levels and thei …
MiR-20b-5p involves in vascular aging induced by hyperhomocysteinemia.
Qin H, Hu LL, Wang WJ, Yu ZZ, Chen Y, Zhao YB, Liao YH, Zhang WL, Yang RQ. Qin H, et al. Exp Gerontol. 2023 Dec;184:112330. doi: 10.1016/j.exger.2023.112330. Epub 2023 Nov 16. Exp Gerontol. 2023. PMID: 37967592 Free article.
Using TargetScan and miRDB web tools, 29 miRNA-mRNA pairs were predicted. Notably, miR-20b-5p and FJX1 shared the highest predicted score in TargetScan, and further study indicated that the miR-20b-5p inhibitor significantly upregulated the FJX1 expression in HHcy h …
Using TargetScan and miRDB web tools, 29 miRNA-mRNA pairs were predicted. Notably, miR-20b-5p and FJX1 shared the highest predicted s …
MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT.
Peng Y, Qin Y, Zhang X, Deng S, Yuan Y, Feng X, Chen W, Hu F, Gao Y, He J, Cheng Y, Wei Y, Fan X, Ashktorab H, Smoot D, Li S, Meltzer SJ, Zhuang S, Tang N, Jin Z. Peng Y, et al. Heliyon. 2021 Apr 12;7(4):e06695. doi: 10.1016/j.heliyon.2021.e06695. eCollection 2021 Apr. Heliyon. 2021. PMID: 33912703 Free PMC article.
Previous research has found that miRNA-20b is highly expressed in gastric cancer (GC), however, its function and underlying mechanism are not clear. ...SUFU, negatively regulating Wnt and Hedgehog signaling pathway, was proved to be targeted by miRNA-20b. Moreover, …
Previous research has found that miRNA-20b is highly expressed in gastric cancer (GC), however, its function and underlying mechanism …
Increased level of exosomal miR-20b-5p derived from hypothermia-treated microglia promotes neurite outgrowth and synapse recovery after traumatic brain injury.
Wang C, Ji Y, Zhang H, Ye Y, Zhang G, Zhang S, Zhao C, Wang Y. Wang C, et al. Neurobiol Dis. 2023 Apr;179:106042. doi: 10.1016/j.nbd.2023.106042. Epub 2023 Feb 17. Neurobiol Dis. 2023. PMID: 36804284 Free article.
Moreover, MG-LPS-EXO(HT) improved motor function and motor coordination. A high-throughput sequencing showed that miR-20b-5p was upregulated in MG-LPS-EXO(HT). Elevating miR-20b-5p promoted neurite outgrowth and synapse recovery of injured neurons both in vitro and …
Moreover, MG-LPS-EXO(HT) improved motor function and motor coordination. A high-throughput sequencing showed that miR-20b-5p was upre …
Prognostic Value of MicroRNA-20b in Acute Myeloid Leukemia.
Cheng Z, Dai Y, Huang W, Zhong Q, Zhu P, Zhang W, Wu Z, Lin Q, Zhu H, Cui L, Qian T, Deng C, Fu L, Liu Y, Zeng T. Cheng Z, et al. Front Oncol. 2021 Feb 18;10:553344. doi: 10.3389/fonc.2020.553344. eCollection 2020. Front Oncol. 2021. PMID: 33680910 Free PMC article.
ORAI2, the gene with the strongest correlation with miR-20b, also had significant prognostic value in patients undergoing chemotherapy but not in the allo-HSCT group. In conclusion, our findings suggest that high miR-20b expression is a poor prognostic indicator for …
ORAI2, the gene with the strongest correlation with miR-20b, also had significant prognostic value in patients undergoing chemotherap …
Plasma exosomes and contained MiRNAs affect the reproductive phenotype in polycystic ovary syndrome.
Jiang X, Zhang Z, Hou M, Yang X, Cui L. Jiang X, et al. FASEB J. 2023 Jul;37(7):e22960. doi: 10.1096/fj.202201940RR. FASEB J. 2023. PMID: 37335566
KGN cells were cultured and transfected with mimics and inhibitors of differentially expressed exosomal miRNAs (miR-18a-3p, miR-20b-5p, miR-106a-5p, miR-126-3p, and miR-146a-5p) and then tested for steroid hormone synthesis, proliferation, and apoptosis. ...
KGN cells were cultured and transfected with mimics and inhibitors of differentially expressed exosomal miRNAs (miR-18a-3p, miR-20b-5 …
MiR-20b-5p promotes hepatocellular carcinoma cell proliferation, migration and invasion by down-regulating CPEB3.
Li Z, Wu L, Tan W, Zhang K, Lin Q, Zhu J, Tu C, Lv X, Jiang C. Li Z, et al. Ann Hepatol. 2021 Jul-Aug;23:100345. doi: 10.1016/j.aohep.2021.100345. Epub 2021 Mar 31. Ann Hepatol. 2021. PMID: 33812045 Free article.
INTRODUCTION AND OBJECTIVES: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation element binding protein 3 (miR-20b-5p/CPEB3) axis in hepatocellular carcinoma (HCC) so as to provide a new idea for targeted therapy of …
INTRODUCTION AND OBJECTIVES: This study aimed to explore the functional mechanism of the miRNA-20b-5p/cytoplasmic polyadenylation ele …
miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer.
Yang H, Lin J, Jiang J, Ji J, Wang C, Zhang J. Yang H, et al. Cell Cycle. 2020 Nov;19(21):2939-2954. doi: 10.1080/15384101.2020.1829824. Epub 2020 Oct 12. Cell Cycle. 2020. PMID: 33044899 Free PMC article.
CyclinD1 (CCND1) was identified as a direct target of miR-20b-5p. Overexpression of miRNA-20b-5p downregulated CCND1 level in HCT-116 cells. ...Our data demonstrated that miR-20b-5p may serve as a tumor suppressor in colon cancer by negatively regulating CCND …
CyclinD1 (CCND1) was identified as a direct target of miR-20b-5p. Overexpression of miRNA-20b-5p downregulated CCND1 level in …
Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b.
Qian K, Zhang L, Shi K. Qian K, et al. Inflammopharmacology. 2019 Feb;27(1):109-119. doi: 10.1007/s10787-018-0509-6. Epub 2018 Jul 5. Inflammopharmacology. 2019. PMID: 29974310
Further mechanistic studies showed that the reduction of pro-inflammatory cytokines by triptolide was mediated by the upregulation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) and downregulation of caspase-1. Finally, …
Further mechanistic studies showed that the reduction of pro-inflammatory cytokines by triptolide was mediated by the upregulation of nucleo …
MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca(2+) Cross-Talk.
Qiu Y, Cheng R, Liang C, Yao Y, Zhang W, Zhang J, Zhang M, Li B, Xu C, Zhang R. Qiu Y, et al. Mol Ther Nucleic Acids. 2020 Mar 6;19:1343-1356. doi: 10.1016/j.omtn.2020.01.017. Epub 2020 Jan 23. Mol Ther Nucleic Acids. 2020. PMID: 32160705 Free PMC article.
Our data showed that miR-20b induced cardiac hypertrophy that was reversed by recombinant adeno-associated virus vector 9 (rAAV9)-anti-miR-20b or miR-20b antisense inhibitor (AMO-20b). The deleterious action of miR-20b on Mfn2 expression/functio …
Our data showed that miR-20b induced cardiac hypertrophy that was reversed by recombinant adeno-associated virus vector 9 (rAAV9)-ant …
135 results