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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 2
1993 1
1994 1
1996 1
2008 2
2009 1
2010 3
2012 3
2013 2
2014 1
2016 3
2017 4
2018 4
2019 4
2020 3
2021 5
2022 1
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40 results
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Page 1
Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.
Brown CR, Gupta S, Qin J, Racie T, He G, Lentini S, Malone R, Yu M, Matsuda S, Shulga-Morskaya S, Nair AV, Theile CS, Schmidt K, Shahraz A, Goel V, Parmar RG, Zlatev I, Schlegel MK, Nair JK, Jayaraman M, Manoharan M, Brown D, Maier MA, Jadhav V. Brown CR, et al. Among authors: zlatev i. Nucleic Acids Res. 2020 Dec 2;48(21):11827-11844. doi: 10.1093/nar/gkaa670. Nucleic Acids Res. 2020. PMID: 32808038 Free PMC article.
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
Janas MM, Schlegel MK, Harbison CE, Yilmaz VO, Jiang Y, Parmar R, Zlatev I, Castoreno A, Xu H, Shulga-Morskaya S, Rajeev KG, Manoharan M, Keirstead ND, Maier MA, Jadhav V. Janas MM, et al. Among authors: zlatev i. Nat Commun. 2018 Feb 19;9(1):723. doi: 10.1038/s41467-018-02989-4. Nat Commun. 2018. PMID: 29459660 Free PMC article.
The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man.
Chong S, Agarwal S, Agarwal S, Aluri KC, Arciprete M, Brown C, Charisse K, Cichocki J, Fitzgerald K, Goel V, Gu Y, Guenther D, Habtemariam B, Jadhav V, Janas M, Jayaraman M, Kurz J, Li J, Liou S, Liu J, Liu X, Maclauchlin C, Maier M, Manoharan M, McDougall R, Nair J, Ramsden D, Robbie G, Schmidt K, Smith P, Theile C, Vaishnaw A, Waldron S, Wu JT, Xu Y, Zhang X, Zlatev I, Castellanos-Rizaldos E. Chong S, et al. Among authors: zlatev i. Drug Metab Dispos. 2021 Jun 21:DMD-MR-2021-000428. doi: 10.1124/dmd.121.000428. Online ahead of print. Drug Metab Dispos. 2021. PMID: 34154993 Free article.
Reversal of siRNA-mediated gene silencing in vivo.
Zlatev I, Castoreno A, Brown CR, Qin J, Waldron S, Schlegel MK, Degaonkar R, Shulga-Morskaya S, Xu H, Gupta S, Matsuda S, Akinc A, Rajeev KG, Manoharan M, Maier MA, Jadhav V. Zlatev I, et al. Nat Biotechnol. 2018 Jul;36(6):509-511. doi: 10.1038/nbt.4136. Epub 2018 May 14. Nat Biotechnol. 2018. PMID: 29786096
Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease.
Bovée DM, Ren L, Uijl E, Clahsen-van Groningen MC, van Veghel R, Garrelds IM, Domenig O, Poglitsch M, Zlatev I, Kim JB, Huang S, Melton L, Lu X, Hoorn EJ, Foster D, Danser AHJ. Bovée DM, et al. Among authors: zlatev i. Hypertension. 2021 May 5;77(5):1600-1612. doi: 10.1161/HYPERTENSIONAHA.120.16876. Epub 2021 Mar 15. Hypertension. 2021. PMID: 33719507
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing.
Jahns H, Degaonkar R, Podbevsek P, Gupta S, Bisbe A, Aluri K, Szeto J, Kumar P, LeBlanc S, Racie T, Brown CR, Castoreno A, Guenther DC, Jadhav V, Maier MA, Plavec J, Egli M, Manoharan M, Zlatev I. Jahns H, et al. Among authors: zlatev i. Nucleic Acids Res. 2021 Oct 11;49(18):10250-10264. doi: 10.1093/nar/gkab724. Nucleic Acids Res. 2021. PMID: 34508350 Free PMC article.
Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates.
Janas MM, Zlatev I, Liu J, Jiang Y, Barros SA, Sutherland JE, Davis WP, Liu J, Brown CR, Liu X, Schlegel MK, Blair L, Zhang X, Das B, Tran C, Aluri K, Li J, Agarwal S, Indrakanti R, Charisse K, Nair J, Matsuda S, Rajeev KG, Zimmermann T, Sepp-Lorenzino L, Xu Y, Akinc A, Fitzgerald K, Vaishnaw AK, Smith PF, Manoharan M, Jadhav V, Wu JT, Maier MA. Janas MM, et al. Among authors: zlatev i. Nucleic Acids Res. 2019 Apr 23;47(7):3306-3320. doi: 10.1093/nar/gkz140. Nucleic Acids Res. 2019. PMID: 30820542 Free PMC article.
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
Akabane-Nakata M, Erande ND, Kumar P, Degaonkar R, Gilbert JA, Qin J, Mendez M, Woods LB, Jiang Y, Janas MM, O'Flaherty DK, Zlatev I, Schlegel MK, Matsuda S, Egli M, Manoharan M. Akabane-Nakata M, et al. Among authors: zlatev i. Nucleic Acids Res. 2021 Mar 18;49(5):2435-2449. doi: 10.1093/nar/gkab050. Nucleic Acids Res. 2021. PMID: 33577685 Free PMC article.
40 results