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58 results

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Page 1
Selective Inhibitors of G2019S-LRRK2 Kinase Activity.
Garofalo AW, Bright J, De Lombaert S, Toda AMA, Zobel K, Andreotti D, Beato C, Bernardi S, Budassi F, Caberlotto L, Gao P, Griffante C, Liu X, Mengatto L, Migliore M, Sabbatini FM, Sava A, Serra E, Vincetti P, Zhang M, Carlisle HJ. Garofalo AW, et al. Among authors: zobel k. J Med Chem. 2020 Dec 10;63(23):14821-14839. doi: 10.1021/acs.jmedchem.0c01243. Epub 2020 Nov 16. J Med Chem. 2020. PMID: 33197196
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.
Garofalo AW, Schwarz J, Zobel K, Beato C, Bernardi S, Budassi F, Caberlotto L, Gao P, Griffante C, Liu X, Migliore M, Qiao F, Sabbatini FM, Sava A, Zhang M, Carlisle HJ. Garofalo AW, et al. Among authors: zobel k. Bioorg Med Chem Lett. 2023 Oct 15;95:129487. doi: 10.1016/j.bmcl.2023.129487. Epub 2023 Sep 19. Bioorg Med Chem Lett. 2023. PMID: 37734423
Internal motions prime cIAP1 for rapid activation.
Phillips AH, Schoeffler AJ, Matsui T, Weiss TM, Blankenship JW, Zobel K, Giannetti AM, Dueber EC, Fairbrother WJ. Phillips AH, et al. Among authors: zobel k. Nat Struct Mol Biol. 2014 Dec;21(12):1068-74. doi: 10.1038/nsmb.2916. Epub 2014 Nov 10. Nat Struct Mol Biol. 2014. PMID: 25383668
Ecological assembly rules in plant communities--approaches, patterns and prospects.
Götzenberger L, de Bello F, Bråthen KA, Davison J, Dubuis A, Guisan A, Lepš J, Lindborg R, Moora M, Pärtel M, Pellissier L, Pottier J, Vittoz P, Zobel K, Zobel M. Götzenberger L, et al. Among authors: zobel k. Biol Rev Camb Philos Soc. 2012 Feb;87(1):111-27. doi: 10.1111/j.1469-185X.2011.00187.x. Epub 2011 Jun 21. Biol Rev Camb Philos Soc. 2012. PMID: 21692965 Review.
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.
Goncharov T, Hedayati S, Mulvihill MM, Izrael-Tomasevic A, Zobel K, Jeet S, Fedorova AV, Eidenschenk C, deVoss J, Yu K, Shaw AS, Kirkpatrick DS, Fairbrother WJ, Deshayes K, Vucic D. Goncharov T, et al. Among authors: zobel k. Mol Cell. 2018 Feb 15;69(4):551-565.e7. doi: 10.1016/j.molcel.2018.01.016. Mol Cell. 2018. PMID: 29452636 Free article.
Structure-guided design of a selective BCL-X(L) inhibitor.
Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG. Lessene G, et al. Among authors: zobel k. Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21. Nat Chem Biol. 2013. PMID: 23603658
Further insights into the effects of pre-organizing the BimBH3 helix.
Okamoto T, Segal D, Zobel K, Fedorova A, Yang H, Fairbrother WJ, Huang DC, Smith BJ, Deshayes K, Czabotar PE. Okamoto T, et al. Among authors: zobel k. ACS Chem Biol. 2014 Mar 21;9(3):838-9. doi: 10.1021/cb400638p. Epub 2014 Feb 18. ACS Chem Biol. 2014. PMID: 24547872 No abstract available.
The development of peptide-based tools for the analysis of angiogenesis.
Fedorova A, Zobel K, Gill HS, Ogasawara A, Flores JE, Tinianow JN, Vanderbilt AN, Wu P, Meng YG, Williams SP, Wiesmann C, Murray J, Marik J, Deshayes K. Fedorova A, et al. Among authors: zobel k. Chem Biol. 2011 Jul 29;18(7):839-45. doi: 10.1016/j.chembiol.2011.05.011. Chem Biol. 2011. PMID: 21802005
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ. Dueber EC, et al. Among authors: zobel k. Science. 2011 Oct 21;334(6054):376-80. doi: 10.1126/science.1207862. Science. 2011. PMID: 22021857
58 results