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The following term was not found in PubMed: Gerbeshikov
Page 1
Nerve, Muscle, and Synaptogenesis.
Swenarchuk LE. Swenarchuk LE. Cells. 2019 Nov 16;8(11):1448. doi: 10.3390/cells8111448. Cells. 2019. PMID: 31744142 Free PMC article. Review.
While agrin was initially postulated to be the inductive molecule that initiates synaptogenesis, this model has been modified in response to work showing that postsynaptic differentiation can develop in the absence of innervation, and that synapses can form in transgenic m …
While agrin was initially postulated to be the inductive molecule that initiates synaptogenesis, this model has been modified in resp …
The agrin hypothesis.
McMahan UJ. McMahan UJ. Cold Spring Harb Symp Quant Biol. 1990;55:407-18. doi: 10.1101/sqb.1990.055.01.041. Cold Spring Harb Symp Quant Biol. 1990. PMID: 1966767 Review. No abstract available.
An Agrin-YAP/TAZ Rigidity Sensing Module Drives EGFR-Addicted Lung Tumorigenesis.
Mokhtari RB, Sampath D, Eversole P, Yu Lin MO, Bosykh DA, Boopathy GTK, Sivakumar A, Wang CC, Kumar R, Sheng JYP, Karasik E, Foster BA, Yu H, Ling X, Wu W, Li F, Ohler ZW, Brainson CF, Goodrich DW, Hong W, Chakraborty S. Mokhtari RB, et al. Adv Sci (Weinh). 2025 May;12(20):e2413443. doi: 10.1002/advs.202413443. Epub 2025 Mar 31. Adv Sci (Weinh). 2025. PMID: 40165020 Free PMC article.
Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. ...Notably, a feed-forward loop linking agrin-EGFR rigidity response to YAP-TEAD mechanosensing is essential for tumorigenesis. ...
Agrin expression confers substrate stiffness-dependent oncogenic attributes to EGFR-reliant cancer cells. ...Notably, a feed-forward …
Neuromuscular sarcopenia: what do we know?
Drey M. Drey M. Curr Opin Neurol. 2025 Oct 1;38(5):560-565. doi: 10.1097/WCO.0000000000001373. Epub 2025 May 16. Curr Opin Neurol. 2025. PMID: 40377685 Review.
Inactivation of agrin leads to destabilization of the neuromuscular junction and thus to sarcopenia. The resulting neuronal 22 kDa C-terminal agrin fragment should serve as a biomarker of neuromuscular sarcopenia. ...On this basis, treatment with agrin could …
Inactivation of agrin leads to destabilization of the neuromuscular junction and thus to sarcopenia. The resulting neuronal 22 kDa C- …
The protective role of Agrin and CAF22 in hypertensive nephropathy.
Yuan C, Zhang P, Zhan Z, Guo Y, Huang P, Qian J, Wang W, Shan P. Yuan C, et al. Int Immunopharmacol. 2025 Sep 23;162:115107. doi: 10.1016/j.intimp.2025.115107. Epub 2025 Jun 20. Int Immunopharmacol. 2025. PMID: 40543102
BACKGROUND: Hypertensive nephropathy (HN), a major complication of hypertension, is characterized by key pathological features such as renal inflammation and fibrosis. Recent studies have demonstrated that Agrin plays a significant role in tissues such as the heart and ske …
BACKGROUND: Hypertensive nephropathy (HN), a major complication of hypertension, is characterized by key pathological features such as renal …
Functions of agrin and agrin-related proteins.
Patthy L, Nikolics K. Patthy L, et al. Trends Neurosci. 1993 Feb;16(2):76-81. doi: 10.1016/0166-2236(93)90021-d. Trends Neurosci. 1993. PMID: 7680504 Review.
Agrin-related proteins (ARPs) that arise from differential splicing are synthesized by neurons and muscle. ...Beyond agrin's role in inducing AChR aggregation, the function of agrin and ARPs to provide a localized reservoir of growth factors could cont …
Agrin-related proteins (ARPs) that arise from differential splicing are synthesized by neurons and muscle. ...Beyond agrin' …
Agrin-like proteins of the neuromuscular junction.
Patthy L, Nikolics K. Patthy L, et al. Neurochem Int. 1994 Apr;24(4):301-16. doi: 10.1016/0197-0186(94)90108-2. Neurochem Int. 1994. PMID: 8061595 Review.
Agrin, a molecule synthesized by motorneurons, plays a key role in the formation of the neuromuscular junction. Agrin is released from motoneurons at the axon terminal after anterograde axonal transport and binds to agrin receptors present on muscle cells. .. …
Agrin, a molecule synthesized by motorneurons, plays a key role in the formation of the neuromuscular junction. Agrin is relea …
Anti-agrin autoantibodies in myasthenia gravis.
Gasperi C, Melms A, Schoser B, Zhang Y, Meltoranta J, Risson V, Schaeffer L, Schalke B, Kröger S. Gasperi C, et al. Neurology. 2014 Jun 3;82(22):1976-83. doi: 10.1212/WNL.0000000000000478. Epub 2014 May 2. Neurology. 2014. PMID: 24793185
OBJECTIVE: Because the extracellular matrix protein agrin is essential for neuromuscular junction formation and maintenance, we tested the hypothesis that autoantibodies against agrin are present in sera from patients with myasthenia gravis (MG). METHODS: We determi …
OBJECTIVE: Because the extracellular matrix protein agrin is essential for neuromuscular junction formation and maintenance, we teste …
Agrin/Dok-7-induced JPH2 phosphorylation in muscle cells is involved in AChR clustering.
Wang B, Cui M, Liu H, Sui M, Wu X, Liu Y, Zhang B. Wang B, et al. FEBS Lett. 2025 Aug;599(15):2142-2156. doi: 10.1002/1873-3468.70050. Epub 2025 Apr 28. FEBS Lett. 2025. PMID: 40290048
The neuromuscular junction (NMJ) performs the crucial function of controlling skeletal muscle contraction. NMJ formation depends on the Agrin/Lrp4/MuSK/Dok-7 signaling pathway. However, signaling downstream of Dok-7 remains incompletely understood. ...Our phosphoproteomics …
The neuromuscular junction (NMJ) performs the crucial function of controlling skeletal muscle contraction. NMJ formation depends on the A …
Agrin in the CNS: a protein in search of a function?
Smith MA, Hilgenberg LG. Smith MA, et al. Neuroreport. 2002 Aug 27;13(12):1485-95. doi: 10.1097/00001756-200208270-00001. Neuroreport. 2002. PMID: 12218692 Review.
Agrin is also present in the CNS. However, while its spatiotemporal pattern of expression is consistent with a function in neuron-neuron synapse formation, it also suggests a role for agrin in other aspects of neural tissue morphogenesis. ...Possible roles for ag …
Agrin is also present in the CNS. However, while its spatiotemporal pattern of expression is consistent with a function in neuron-neu …
1,590 results