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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 2
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1977 6
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1981 15
1982 11
1983 18
1984 30
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1986 34
1987 39
1988 41
1989 38
1990 42
1991 46
1992 13
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1997 30
1998 35
1999 46
2000 31
2001 35
2002 21
2003 20
2004 34
2005 18
2006 45
2007 51
2008 54
2009 45
2010 43
2011 42
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1,957 results

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Page 1
Aspartame-True or False? Narrative Review of Safety Analysis of General Use in Products.
Czarnecka K, Pilarz A, Rogut A, Maj P, Szymańska J, Olejnik Ł, Szymański P. Czarnecka K, et al. Nutrients. 2021 Jun 7;13(6):1957. doi: 10.3390/nu13061957. Nutrients. 2021. PMID: 34200310 Free PMC article. Review.
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. ...Further research should be conducted to ensure clear information about the impact of aspartame on health....
Aspartame is a sweetener introduced to replace the commonly used sucrose. It was discovered by James M. ...Further research should be
Revisiting the safety of aspartame.
Choudhary AK, Pretorius E. Choudhary AK, et al. Nutr Rev. 2017 Sep 1;75(9):718-730. doi: 10.1093/nutrit/nux035. Nutr Rev. 2017. PMID: 28938797 Review.
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. ...Since aspartame consumption is on the rise, the safety of this sweetener should be revisited. ...
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and
Understanding the link between aspartame and cancer.
Soffritti M. Soffritti M. Expert Rev Anticancer Ther. 2024 Sep;24(9):793-802. doi: 10.1080/14737140.2024.2383675. Epub 2024 Jul 31. Expert Rev Anticancer Ther. 2024. PMID: 39041328 Review.
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results. AREAS COVERED: Because of the great commercial diffusion of aspartame, in 1997 the Ramazzini Institute (RI) started
Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced contro
Aspartame carcinogenic potential revealed through network toxicology and molecular docking insights.
Chen D, Hou X. Chen D, et al. Sci Rep. 2024 May 20;14(1):11492. doi: 10.1038/s41598-024-62461-w. Sci Rep. 2024. PMID: 38769413 Free PMC article.
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and mechanisms of aspartame (L-alpha-aspartyl-L-phenylalanine methyl ester). Aspartame, a commonly used synthetic sweetener, is wid …
The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects and m …
Carcinogenicity of aspartame, methyleugenol, and isoeugenol.
Riboli E, Beland FA, Lachenmeier DW, Marques MM, Phillips DH, Schernhammer E, Afghan A, Assunção R, Caderni G, Corton JC, de Aragão Umbuzeiro G, de Jong D, Deschasaux-Tanguy M, Hodge A, Ishihara J, Levy DD, Mandrioli D, McCullough ML, McNaughton SA, Morita T, Nugent AP, Ogawa K, Pandiri AR, Sergi CM, Touvier M, Zhang L, Benbrahim-Tallaa L, Chittiboyina S, Cuomo D, DeBono NL, Debras C, de Conti A, El Ghissassi F, Fontvieille E, Harewood R, Kaldor J, Mattock H, Pasqual E, Rigutto G, Simba H, Suonio E, Viegas S, Wedekind R, Schubauer-Berigan MK, Madia F. Riboli E, et al. Lancet Oncol. 2023 Aug;24(8):848-850. doi: 10.1016/S1470-2045(23)00341-8. Epub 2023 Jul 13. Lancet Oncol. 2023. PMID: 37454664 No abstract available.
Aspartame and cancer - new evidence for causation.
Landrigan PJ, Straif K. Landrigan PJ, et al. Environ Health. 2021 Apr 12;20(1):42. doi: 10.1186/s12940-021-00725-y. Environ Health. 2021. PMID: 33845854 Free PMC article.
In light of them, we encourage all national and international public health agencies to urgently reexamine their assessments of aspartame's health risks - especially the risks of prenatal and early postnatal exposures. We call upon food agencies to reassess Acceptab …
In light of them, we encourage all national and international public health agencies to urgently reexamine their assessments of aspartame
Aspartame increases the risk of liver cancer through CASP1 protein: A comprehensive network analysis insights.
Li NR, Zeng YX, Gu YF, Xie P, Deng BY, Lu SF, Li WA, Liu Y. Li NR, et al. Ecotoxicol Environ Saf. 2025 Apr 1;294:118089. doi: 10.1016/j.ecoenv.2025.118089. Epub 2025 Mar 25. Ecotoxicol Environ Saf. 2025. PMID: 40139029 Free article.
METHODS: ProTox 3.0 and ADMEtlab 2.0 platforms were used to predict the toxicity and drug metabolism levels of aspartame. Network toxicology methods were employed to investigate the pathogenic pathways and mechanisms of aspartame in liver cancer. Mendelian randomiza …
METHODS: ProTox 3.0 and ADMEtlab 2.0 platforms were used to predict the toxicity and drug metabolism levels of aspartame. Network tox …
Metabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trials.
Santos NC, de Araujo LM, De Luca Canto G, Guerra ENS, Coelho MS, Borin MF. Santos NC, et al. Crit Rev Food Sci Nutr. 2018;58(12):2068-2081. doi: 10.1080/10408398.2017.1304358. Epub 2017 Aug 18. Crit Rev Food Sci Nutr. 2018. PMID: 28394643
Data about harms or benefits associated with the consumption of aspartame, a nonnutritive sweetener worldwide consumed, are still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame
Data about harms or benefits associated with the consumption of aspartame, a nonnutritive sweetener worldwide consumed, are still con …
Aspartame intolerance.
Garriga MM, Metcalfe DD. Garriga MM, et al. Ann Allergy. 1988 Dec;61(6 Pt 2):63-9. Ann Allergy. 1988. PMID: 3061324 Review.
Aspartame is a food additive marketed under the brand name Nutrasweet. Aspartame is a white, odorless, crystalline powder and consists of two amino acids, L-aspartic acid and L-phenylalanine. ...FDA's Center for Food Safety and Applied Nutrition (CFSAN) monitors
Aspartame is a food additive marketed under the brand name Nutrasweet. Aspartame is a white, odorless, crystalline powder and
Mutagenicity and genotoxicity studies of aspartame.
Otabe A, Ohta F, Takumi A, Lynch B. Otabe A, et al. Regul Toxicol Pharmacol. 2019 Apr;103:345-351. doi: 10.1016/j.yrtph.2018.01.023. Epub 2018 Feb 19. Regul Toxicol Pharmacol. 2019. PMID: 29408486 Free article. Review.
In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2 uvrA were treated with aspartame at concentrations of up to 5000 mug/plate with or without metabolic activation and showed no mutag …
In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP …
1,957 results