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2021 2
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Page 1
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Wang C, Sun S, Jiao J, Yu X, Huang S. Wang C, et al. Fundam Clin Pharmacol. 2022 Oct;36(5):811-817. doi: 10.1111/fcp.12778. Epub 2022 Apr 9. Fundam Clin Pharmacol. 2022. PMID: 35373856
However, no evidence is available concerning the effect of nalbuphine on the cardiotoxicity of local anesthetics. The objective of this work is to investigate whether nalbuphine pretreatment can increase the lethal dose threshold of ropivacaine in rats. ...Nalbuphine doses …
However, no evidence is available concerning the effect of nalbuphine on the cardiotoxicity of local anesthetics. The objective of th …
Local and Regional Anesthesia in Zoological Companion Animal Practice.
DiGeronimo PM, da Cunha AF. DiGeronimo PM, et al. Vet Clin North Am Exot Anim Pract. 2022 Jan;25(1):321-336. doi: 10.1016/j.cvex.2021.08.015. Vet Clin North Am Exot Anim Pract. 2022. PMID: 34823697 Review.
They work by blocking the voltage-dependent sodium ion channels along neurons that mediate nociception. Systemically, these drugs can be cardiotoxic in a dose-dependent manner. Lidocaine and bupivacaine are the most commonly used local anesthetics and their use has …
They work by blocking the voltage-dependent sodium ion channels along neurons that mediate nociception. Systemically, these drugs can be …
Intralipid fails to rescue bupivacaine-induced cardiotoxicity in late-pregnant rats.
Sherman C, Koons N, Zargari M, Cha C, Hirsch J, Hong R, Eghbali M, Umar S. Sherman C, et al. Front Med (Lausanne). 2022 Aug 12;9:899036. doi: 10.3389/fmed.2022.899036. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36035396 Free PMC article.
BACKGROUND: Females routinely receive bupivacaine for obstetric and regional anesthesia. An accidental overdose of bupivacaine can result in cardiotoxicity and cardiac arrest. Intralipid (ILP) rescues bupivacaine-induced cardiotoxicity in male r …
BACKGROUND: Females routinely receive bupivacaine for obstetric and regional anesthesia. An accidental overdose of bupivacaine …
Apelin-13 reverses bupivacaine-induced cardiotoxicity: an experimental study.
Cai X, Liu L, Xia F, Papadimos TJ, Wang Q. Cai X, et al. Braz J Anesthesiol. 2024 May-Jun;74(3):844501. doi: 10.1016/j.bjane.2024.844501. Epub 2024 Apr 5. Braz J Anesthesiol. 2024. PMID: 38583586 Free PMC article.
This study aimed to investigate the effects of apelin-13 in reversing cardiac suppression induced by bupivacaine in rats. METHODS: A rat model of cardiac suppression was established by a 3-min continuous intravenous infusion of bupivacaine at the rate of 5 mg.kg(-1) …
This study aimed to investigate the effects of apelin-13 in reversing cardiac suppression induced by bupivacaine in rats. METHODS: A …
Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics.
Plakhotnik J, Zhang L, Estrada M, Coles JG, Lonnqvist PA, Maynes JT. Plakhotnik J, et al. Anesthesiology. 2022 Dec 1;137(6):687-703. doi: 10.1097/ALN.0000000000004389. Anesthesiology. 2022. PMID: 36170651
Calcium channel blocker nifedipine coadministration with bupivacaine, but not ropivacaine, exacerbated cardiotoxicity, supporting the role of calcium flux in differentiating toxicity. CONCLUSIONS: Our data illustrate differences in calcium dynamics between anestheti …
Calcium channel blocker nifedipine coadministration with bupivacaine, but not ropivacaine, exacerbated cardiotoxicity, support …
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate-Activated Protein Kinase Pathway.
Ye Y, Cai Y, Xia E, Shi K, Jin Z, Chen H, Xia F, Xia Y, Papadimos TJ, Xu X, Liu L, Wang Q. Ye Y, et al. Anesth Analg. 2021 Oct 1;133(4):1048-1059. doi: 10.1213/ANE.0000000000005692. Anesth Analg. 2021. PMID: 34524989
In this study, we examined whether exogenous (Pyr1) apelin-13 could reverse bupivacaine-induced cardiotoxicity. METHODS: We used the bupivacaine-induced inhibition model in adult male Sprague Dawley (SD) rats (n = 48) and H9c2 cardiomyocyte cell cultures to e …
In this study, we examined whether exogenous (Pyr1) apelin-13 could reverse bupivacaine-induced cardiotoxicity. METHODS: We us …
SK2 channel deletion reduces susceptibility to bupivacaine-induced cardiotoxicity in mouse.
Chen H, Jin Z, Fu Z, Xia F. Chen H, et al. Hum Exp Toxicol. 2021 Oct;40(10):1796-1802. doi: 10.1177/09603271211010912. Epub 2021 Apr 23. Hum Exp Toxicol. 2021. PMID: 33887967
The mechanism of bupivacaine-mediated cardiotoxicity remains unclear. SK2 knockout mice (SK) and wild-type mice (WT) were divided into four groups, with 12 mice per group. ...Knocking out the SK2 channel can reduce bupivacaine-induced cardiotoxicity in …
The mechanism of bupivacaine-mediated cardiotoxicity remains unclear. SK2 knockout mice (SK) and wild-type mice (WT) were divi …
Intrathecal ropivacaine versus bupivacaine in a non-obstetric population- A meta-analysis and trial sequential analysis.
Khalil RS, Mehmud A, Banerjee R, Malhotra R, Banerjee A. Khalil RS, et al. Indian J Anaesth. 2024 Feb;68(2):129-141. doi: 10.4103/ija.ija_715_23. Epub 2024 Jan 29. Indian J Anaesth. 2024. PMID: 38435645 Free PMC article.
BACKGROUND AND AIMS: Intrathecal bupivacaine is used for anaesthesia and analgesia but is associated with hypotension. Ropivacaine is an alternative drug that may have fewer cardiotoxic and neurotoxic events. ...The duration of analgesia favoured intrathecal bupi …
BACKGROUND AND AIMS: Intrathecal bupivacaine is used for anaesthesia and analgesia but is associated with hypotension. Ropivacaine is …
Effects of delta-opioid receptor agonist pretreatment on the cardiotoxicity of bupivacaine in rats.
Wang C, Sun S, Jiao J, Yu X, Huang S. Wang C, et al. BMC Anesthesiol. 2022 Jan 12;22(1):19. doi: 10.1186/s12871-022-01568-x. BMC Anesthesiol. 2022. PMID: 35021986 Free PMC article.
The antagonist of delta-opioid receptor could block the rescue effect of lipid emulsion against local anesthetic cardiotoxicity. However, no evidence is available for the direct effect of delta-opioid-receptor agonists on the cardiotoxicity of local anesthetics. ... …
The antagonist of delta-opioid receptor could block the rescue effect of lipid emulsion against local anesthetic cardiotoxicity. Howe …
26 results