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LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation.
Pischedda F, Cirnaru MD, Ponzoni L, Sandre M, Biosa A, Carrion MP, Marin O, Morari M, Pan L, Greggio E, Bandopadhyay R, Sala M, Piccoli G. Pischedda F, et al. Among authors: cirnaru md. Brain. 2021 Jun 22;144(5):1509-1525. doi: 10.1093/brain/awab073. Brain. 2021. PMID: 33876242
An atlas of chromatin accessibility in the adult human brain.
Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P. Fullard JF, et al. Among authors: cirnaru md. Genome Res. 2018 Aug;28(8):1243-1252. doi: 10.1101/gr.232488.117. Epub 2018 Jun 26. Genome Res. 2018. PMID: 29945882 Free PMC article.
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, Greggio E. Belluzzi E, et al. Among authors: cirnaru md. Mol Neurodegener. 2016 Jan 13;11:1. doi: 10.1186/s13024-015-0066-z. Mol Neurodegener. 2016. PMID: 26758690 Free PMC article.
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