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Page 1
Induced hemichorea by cloperastine overuse.
Civardi C, Collini A, Enrico E, Maggio M, Geda C. Civardi C, et al. Neurol Sci. 2020 Jul;41(7):1959-1960. doi: 10.1007/s10072-020-04267-y. Epub 2020 Jan 29. Neurol Sci. 2020. PMID: 31997120 No abstract available.
Cloperastine inhibits esophageal squamous cell carcinoma proliferation in vivo and in vitro by suppressing mitochondrial oxidative phosphorylation.
Li B, Yu Y, Jiang Y, Zhao L, Li A, Li M, Yuan B, Lu J, Dong Z, Zhao J, Liu K. Li B, et al. Cell Death Discov. 2021 Jun 21;7(1):166. doi: 10.1038/s41420-021-00509-w. Cell Death Discov. 2021. PMID: 34226508 Free PMC article.
In the present study, we found that the antitussive agent cloperastine can inhibit the proliferation of ESCC cells. However, the underlying mechanism was unclear. ...Meanwhile, we observed that oxidative phosphorylation in mitochondria was inhibited by the drug. Importantl …
In the present study, we found that the antitussive agent cloperastine can inhibit the proliferation of ESCC cells. However, the unde …
Pharmacokinetics, Bioequivalence and Safety of Cloperastine in Chinese Healthy Subjects Under Fasting and Postprandial Conditions.
Luo HY, Long HZ, Zhou ZW, Xu SG, Li FJ, Cheng Y, Wen DD, Deng P, Gao LC. Luo HY, et al. Drugs R D. 2022 Dec;22(4):311-320. doi: 10.1007/s40268-022-00406-2. Epub 2022 Nov 11. Drugs R D. 2022. PMID: 36369609 Free PMC article. Clinical Trial.
BACKGROUND: Cloperastine is a pivotal antibechic widely prescribed to treat cough caused by respiratory diseases. The present trial evaluated the pharmacokinetics (PK), bioequivalence (BE) and safety effects of the generic test (T) tablet of cloperastine after singl …
BACKGROUND: Cloperastine is a pivotal antibechic widely prescribed to treat cough caused by respiratory diseases. The present trial e …
Cloperastine Reduces IL-6 Expression via Akt/GSK3/Nrf2 Signaling in Monocytes/Macrophages and Ameliorates Symptoms in a Mouse Sepsis Model Induced by Lipopolysaccharide.
Kawamura A, Sawamoto A, Okuyama S, Nakajima M. Kawamura A, et al. Biol Pharm Bull. 2024;47(10):1699-1707. doi: 10.1248/bpb.b24-00472. Biol Pharm Bull. 2024. PMID: 39443088 Free article.
Cloperastine (CLP) is a drug with a central antitussive effect that is used to treat bronchitis. ...
Cloperastine (CLP) is a drug with a central antitussive effect that is used to treat bronchitis. ...
Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol.
Soeda F, Hirakawa E, Inoue M, Shirasaki T, Takahama K. Soeda F, et al. Environ Toxicol. 2014 Feb;29(2):216-25. doi: 10.1002/tox.21749. Epub 2012 Jan 5. Environ Toxicol. 2014. PMID: 22223406
Cloperastine at 10 and 30 mg/kg ameliorated DES-induced impairment of passive avoidance responses. In addition, cloperastine affected the levels of 5-HT1A receptors, GIRK and BDNF in the hippocampus of DES-exposed mice. ...
Cloperastine at 10 and 30 mg/kg ameliorated DES-induced impairment of passive avoidance responses. In addition, cloperastine a …
Identification and quantification of five impurities in cloperastine hydrochloride.
Liu HY, Cheng QZ, Fu HZ, Zhong ZH, Xia HY, Guo YF, Zheng SS, Yu SS. Liu HY, et al. J Pharm Biomed Anal. 2021 Jan 30;193:113731. doi: 10.1016/j.jpba.2020.113731. Epub 2020 Nov 2. J Pharm Biomed Anal. 2021. PMID: 33197833
Impurity A was confirmed as 1-[2-(diphenylmethoxy)ethyl]piperidine, which having one less chloro-substituent compared with cloperastine. Impurity B was confirmed as 1-[2-[(2-chlorophenyl)(phenyl)methoxy]ethyl]piperidine, which was the isomer of cloperastine with 2-c …
Impurity A was confirmed as 1-[2-(diphenylmethoxy)ethyl]piperidine, which having one less chloro-substituent compared with cloperastine …
Cloperastine-based cough syrup and acute dystonic reactions.
Serrano M, Sanz-Cuesta M, Villaronga M, Hayek LF, Perez-Dueñas B. Serrano M, et al. Dev Med Child Neurol. 2012 Mar;54(3):287. doi: 10.1111/j.1469-8749.2011.04105.x. Dev Med Child Neurol. 2012. PMID: 22324643 Free article. No abstract available.
The antitussive cloperastine improves breathing abnormalities in a Rett Syndrome mouse model by blocking presynaptic GIRK channels and enhancing GABA release.
Johnson CM, Cui N, Xing H, Wu Y, Jiang C. Johnson CM, et al. Neuropharmacology. 2020 Oct 1;176:108214. doi: 10.1016/j.neuropharm.2020.108214. Epub 2020 Jul 3. Neuropharmacology. 2020. PMID: 32622786 Free PMC article.
Here we show evidence for the improvement of breathing disorders of Mecp2-disrupted mice with the brainstem-acting drug cloperastine (CPS) and its likely neuronal targets. CPS is an over-the-counter cough medicine that has an inhibitory effect on brainstem neuronal network …
Here we show evidence for the improvement of breathing disorders of Mecp2-disrupted mice with the brainstem-acting drug cloperastine …
Enantioselective LC-MS/MS method for the determination of cloperastine enantiomers in rat plasma and its pharmacokinetic application.
Lun J, Zhao P, Jiang Z, Song Y, Guo X. Lun J, et al. Chirality. 2020 Aug;32(8):1129-1138. doi: 10.1002/chir.23257. Epub 2020 Jun 22. Chirality. 2020. PMID: 32567749
Cloperastine is a central antitussive used to reduce the frequency and intensity of coughing on a short-term basis. ...Cloperastine enantiomers were detected by mass spectrometry in multiple reaction monitoring mode with a positive electrospray ionization source. .. …
Cloperastine is a central antitussive used to reduce the frequency and intensity of coughing on a short-term basis. ...Cloperastin …
Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs.
Takahara A, Fujiwara K, Ohtsuki A, Oka T, Namekata I, Tanaka H. Takahara A, et al. J Pharmacol Sci. 2012;120(3):165-75. doi: 10.1254/jphs.12117fp. Epub 2012 Oct 6. J Pharmacol Sci. 2012. PMID: 23047467 Free article.
Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. ...In the anesthetized guinea pigs, cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and MAP duration without affecting PR interval or QRS width. …
Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. ...In the anesthetized guinea pigs, …
44 results