de Ligt RA[au] - Search Results

Year	Number of Results
2000	1
2002	2
2004	2
2005	2
2015	1
2018	1
2019	1
2021	1
2022	1

1

Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery.

de Ligt RA, Kourounakis AP, IJzerman AP. de Ligt RA, et al. Br J Pharmacol. 2000 May;130(1):1-12. doi: 10.1038/sj.bjp.0703311. Br J Pharmacol. 2000. PMID: 10780991 Free PMC article. Review. No abstract available.

2

Subjective feelings of appetite of wholegrain breakfasts evaluated under controlled, laboratory and 'at home' conditions.

Pasman WJ, Hendriks HFJ, Minekus MM, de Ligt RAF, Scholtes-Timmerman MJ, Clabbers NDS, Leonards NM, Johnson J, Bellmann S. Pasman WJ, et al. Among authors: de ligt raf. Physiol Behav. 2018 Oct 1;194:285-291. doi: 10.1016/j.physbeh.2018.06.024. Epub 2018 Jun 18. Physiol Behav. 2018. PMID: 29913230 Clinical Trial.

3

Appetite ratings of foods are predictable with an in vitro advanced gastrointestinal model in combination with an in silico artificial neural network.

Bellmann S, Krishnan S, de Graaf A, de Ligt RA, Pasman WJ, Minekus M, Havenaar R. Bellmann S, et al. Among authors: de ligt ra. Food Res Int. 2019 Aug;122:77-86. doi: 10.1016/j.foodres.2019.03.051. Epub 2019 Mar 25. Food Res Int. 2019. PMID: 31229132

4

Intrinsic activity at adenosine A1 receptors: partial and inverse agonism.

de Ligt RA, IJzerman AP. de Ligt RA, et al. Curr Pharm Des. 2002;8(26):2333-44. doi: 10.2174/1381612023392874. Curr Pharm Des. 2002. PMID: 12369948 Review.

5

Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages.

Vlaming ML, van Duijn E, Dillingh MR, Brands R, Windhorst AD, Hendrikse NH, Bosgra S, Burggraaf J, de Koning MC, Fidder A, Mocking JA, Sandman H, de Ligt RA, Fabriek BO, Pasman WJ, Seinen W, Alves T, Carrondo M, Peixoto C, Peeters PA, Vaes WH. Vlaming ML, et al. Among authors: de ligt ra. Clin Pharmacol Ther. 2015 Aug;98(2):196-204. doi: 10.1002/cpt.131. Epub 2015 May 19. Clin Pharmacol Ther. 2015. PMID: 25869840 Clinical Trial.

6

Characterization of Clinical Absorption, Distribution, Metabolism, and Excretion and Pharmacokinetics of Velsecorat Using an Intravenous Microtracer Combined with an Inhaled Dose in Healthy Subjects.

Holmberg AA, Weidolf L, Necander S, Bold P, Sidhu S, Pelay-Gimeno M, de Ligt RAF, Verheij ER, Jauhiainen A, Psallidas I, Wählby Hamrén U, Prothon S. Holmberg AA, et al. Among authors: de ligt raf. Drug Metab Dispos. 2022 Feb;50(2):150-157. doi: 10.1124/dmd.121.000632. Epub 2021 Dec 1. Drug Metab Dispos. 2022. PMID: 34853068

7

The influence of microbial metabolites on human intestinal epithelial cells and macrophages in vitro.

van Nuenen MH, de Ligt RA, Doornbos RP, van der Woude JC, Kuipers EJ, Venema K. van Nuenen MH, et al. Among authors: de ligt ra. FEMS Immunol Med Microbiol. 2005 Aug 1;45(2):183-9. doi: 10.1016/j.femsim.2005.03.010. FEMS Immunol Med Microbiol. 2005. PMID: 15939578 Free article.

8

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.

Van Calenbergh S, Link A, Fujikawa S, de Ligt RA, Vanheusden V, Golisade A, Blaton NM, Rozenski J, IJzerman AP, Herdewijn P. Van Calenbergh S, et al. Among authors: de ligt ra. J Med Chem. 2002 Apr 25;45(9):1845-52. doi: 10.1021/jm0110439. J Med Chem. 2002. PMID: 11960496

9

Synthesis and biological evaluation of disubstituted N6-cyclopentyladenine analogues: the search for a neutral antagonist with high affinity for the adenosine A1 receptor.

de Ligt RA, van der Klein PA, von Frijtag Drabbe Künzel JK, Lorenzen A, Ait El Maate F, Fujikawa S, van Westhoven R, van den Hoven T, Brussee J, IJzerman AP. de Ligt RA, et al. Bioorg Med Chem. 2004 Jan 2;12(1):139-49. doi: 10.1016/j.bmc.2003.10.023. Bioorg Med Chem. 2004. PMID: 14697779

10

A "locked-on," constitutively active mutant of the adenosine A1 receptor.

de Ligt RA, Rivkees SA, Lorenzen A, Leurs R, IJzerman AP. de Ligt RA, et al. Eur J Pharmacol. 2005 Mar 7;510(1-2):1-8. doi: 10.1016/j.ejphar.2005.01.007. Eur J Pharmacol. 2005. PMID: 15740718

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