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Page 1
Intestinal organoids for Cystic Fibrosis research.
de Poel E, Lefferts JW, Beekman JM. de Poel E, et al. J Cyst Fibros. 2020 Mar;19 Suppl 1:S60-S64. doi: 10.1016/j.jcf.2019.11.002. Epub 2019 Nov 28. J Cyst Fibros. 2020. PMID: 31787574 Free article. Review.
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo A, Murabito A, Sala V, Pisano AR, Bertolini S, Gianotti A, Caci E, Montresor A, Premchandar A, Pirozzi F, Ren K, Della Sala A, Mergiotti M, Richter W, de Poel E, Matthey M, Caldrer S, Cardone RA, Civiletti F, Costamagna A, Quinney NL, Butnarasu C, Visentin S, Ruggiero MR, Baroni S, Crich SG, Ramel D, Laffargue M, Tocchetti CG, Levi R, Conti M, Lu XY, Melotti P, Sorio C, De Rose V, Facchinetti F, Fanelli V, Wenzel D, Fleischmann BK, Mall MA, Beekman J, Laudanna C, Gentzsch M, Lukacs GL, Pedemonte N, Hirsch E. Ghigo A, et al. Among authors: de poel e. Sci Transl Med. 2022 Mar 30;14(638):eabl6328. doi: 10.1126/scitranslmed.abl6328. Epub 2022 Mar 30. Sci Transl Med. 2022. PMID: 35353541 Free PMC article.
FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes.
de Poel E, Spelier S, Hagemeijer MC, van Mourik P, Suen SWF, Vonk AM, Brunsveld JE, Ithakisiou GN, Kruisselbrink E, Oppelaar H, Berkers G, de Winter de Groot KM, Heida-Michel S, Jans SR, van Panhuis H, Bakker M, van der Meer R, Roukema J, Dompeling E, Weersink EJM, Koppelman GH, Blaazer AR, Muijlwijk-Koezen JE, van der Ent CK, Beekman JM. de Poel E, et al. J Cyst Fibros. 2023 May;22(3):548-559. doi: 10.1016/j.jcf.2023.03.004. Epub 2023 May 3. J Cyst Fibros. 2023. PMID: 37147251
A 'catch-and-release' receptor for the cholera toxin.
Mahon CS, Wildsmith GC, Haksar D, de Poel E, Beekman JM, Pieters RJ, Webb ME, Turnbull WB. Mahon CS, et al. Among authors: de poel e. Faraday Discuss. 2019 Oct 30;219(0):112-127. doi: 10.1039/c9fd00017h. Faraday Discuss. 2019. PMID: 31313796 Free article.
Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids.
de Poel E, Spelier S, Suen SWF, Kruisselbrink E, Graeber SY, Mall MA, Weersink EJM, van der Eerden MM, Koppelman GH, van der Ent CK, Beekman JM. de Poel E, et al. J Cyst Fibros. 2022 Mar;21(2):246-253. doi: 10.1016/j.jcf.2021.09.020. Epub 2021 Oct 17. J Cyst Fibros. 2022. PMID: 34666947 Free article.
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.
Muilwijk D, de Poel E, van Mourik P, Suen SWF, Vonk AM, Brunsveld JE, Kruisselbrink E, Oppelaar H, Hagemeijer MC, Berkers G, de Winter-de Groot KM, Heida-Michel S, Jans SR, van Panhuis H, van der Eerden MM, van der Meer R, Roukema J, Dompeling E, Weersink EJM, Koppelman GH, Vries R, Zomer-van Ommen DD, Eijkemans MJC, van der Ent CK, Beekman JM. Muilwijk D, et al. Among authors: de poel e. Eur Respir J. 2022 Aug 18;60(2):2100508. doi: 10.1183/13993003.00508-2021. Print 2022 Aug. Eur Respir J. 2022. PMID: 35086832 Free PMC article.
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.
Geurts MH, de Poel E, Pleguezuelos-Manzano C, Oka R, Carrillo L, Andersson-Rolf A, Boretto M, Brunsveld JE, van Boxtel R, Beekman JM, Clevers H. Geurts MH, et al. Among authors: de poel e. Life Sci Alliance. 2021 Aug 9;4(10):e202000940. doi: 10.26508/lsa.202000940. Print 2021 Oct. Life Sci Alliance. 2021. PMID: 34373320 Free PMC article.
CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank.
Geurts MH, de Poel E, Amatngalim GD, Oka R, Meijers FM, Kruisselbrink E, van Mourik P, Berkers G, de Winter-de Groot KM, Michel S, Muilwijk D, Aalbers BL, Mullenders J, Boj SF, Suen SWF, Brunsveld JE, Janssens HM, Mall MA, Graeber SY, van Boxtel R, van der Ent CK, Beekman JM, Clevers H. Geurts MH, et al. Among authors: de poel e. Cell Stem Cell. 2020 Apr 2;26(4):503-510.e7. doi: 10.1016/j.stem.2020.01.019. Epub 2020 Feb 20. Cell Stem Cell. 2020. PMID: 32084388 Free article.
15 results