An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo.
Adams JJ, Blazer LL, Chung J, Karimi M, Davidson T, Bruce HA, Singer AU, Yang N, Cardarelli L, Pot I, Colombo L, Huang LJ, Ma Y, Michnick SW, Moe OW, Sidhu SS.
Adams JJ, et al.
Protein Sci. 2025 Oct;34(10):e70292. doi: 10.1002/pro.70292.
Protein Sci. 2025.
PMID: 40960423
Free PMC article.
In a knock-in mouse model, where mouse EPOR was replaced by human EPOR, purified Tb-Fc(2) stimulated erythropoiesis with greater potency, efficacy, and duration than darbepoetin, a recombinant EPO that is the leading therapeutic erythropoiesis-stimulating agent (ESA). Coll …
In a knock-in mouse model, where mouse EPOR was replaced by human EPOR, purified Tb-Fc(2) stimulated erythropoiesis with greater potency, ef …