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269 results

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Page 1
The role of SAF-A/hnRNP U in regulating chromatin structure.
Marenda M, Lazarova E, Gilbert N. Marenda M, et al. Curr Opin Genet Dev. 2022 Feb;72:38-44. doi: 10.1016/j.gde.2021.10.008. Epub 2021 Nov 22. Curr Opin Genet Dev. 2022. PMID: 34823151 Review.
Scaffold attachment factor A (SAF-A) or hnRNP U is a nuclear RNA-binding protein with a well-documented role in processing newly transcribed RNA. ...
Scaffold attachment factor A (SAF-A) or hnRNP U is a nuclear RNA-binding protein with a well-documented role in processing new …
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedláček Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF; SPARK Consortium; Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE. Wang T, et al. Nat Commun. 2020 Oct 1;11(1):4932. doi: 10.1038/s41467-020-18723-y. Nat Commun. 2020. PMID: 33004838 Free PMC article.
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. Isaac R, et al. Cell Metab. 2024 May 7;36(5):1030-1043.e7. doi: 10.1016/j.cmet.2024.04.003. Epub 2024 Apr 25. Cell Metab. 2024. PMID: 38670107 Free PMC article.
Thus, TM7SF3 knockdown promotes alternative splicing of the Hippo pathway transcription factor, TEAD1, by inhibiting the splicing factor heterogeneous nuclear ribonucleoprotein U (hnRNPU). This results in the exclusion of the inhibitory exon 5, generat …
Thus, TM7SF3 knockdown promotes alternative splicing of the Hippo pathway transcription factor, TEAD1, by inhibiting the splicing factor …
Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation.
Hu Y, Li J, Li X, Wang D, Xiang R, Liu W, Hou S, Zhao Q, Yu X, Xu M, Zhao D, Li T, Chi Y, Yang J. Hu Y, et al. Metabolism. 2023 Sep;146:155661. doi: 10.1016/j.metabol.2023.155661. Epub 2023 Jul 16. Metabolism. 2023. PMID: 37454871
RNA sequencing and DNA pull-down revealed that the FAM3D-FPR1 axis upregulated the expression of heterogeneous nuclear ribonucleoprotein U (hnRNP U), which recruits the glucocorticoid receptor (GR) to the promoter region of the short-chai …
RNA sequencing and DNA pull-down revealed that the FAM3D-FPR1 axis upregulated the expression of heterogeneous nuclear ribo …
The RNA-binding domain of hnRNP U extends beyond the RGG/RG motifs.
Kletzien OA, Wuttke DS, Batey RT. Kletzien OA, et al. bioRxiv [Preprint]. 2023 Sep 20:2023.09.20.558674. doi: 10.1101/2023.09.20.558674. bioRxiv. 2023. Update in: Biochemistry. 2024 Feb 8. doi: 10.1021/acs.biochem.3c00510. PMID: 37786719 Free PMC article. Updated. Preprint.
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) is a ubiquitously expressed protein that regulates chromatin architecture through its interactions with numerous DNA, protein, and RNA partners. ...Analysis of publicly available hnRN …
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) is a ubiquitously expressed protein that regul …
The RNA-Binding Domain of hnRNP U Extends beyond the RGG/RG Motifs.
Kletzien OA, Wuttke DS, Batey RT. Kletzien OA, et al. Biochemistry. 2024 Feb 8:10.1021/acs.biochem.3c00510. doi: 10.1021/acs.biochem.3c00510. Online ahead of print. Biochemistry. 2024. PMID: 38329035 Free PMC article.
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) is a ubiquitously expressed protein that regulates chromatin architecture through its interactions with numerous DNA, protein, and RNA partners. ...Analysis of publicly available hnRN …
Heterogeneous nuclear ribonucleoprotein U (hnRNP U) is a ubiquitously expressed protein that regul …
Targeting HNRNPU to overcome cisplatin resistance in bladder cancer.
Shi ZD, Hao L, Han XX, Wu ZX, Pang K, Dong Y, Qin JX, Wang GY, Zhang XM, Xia T, Liang Q, Zhao Y, Li R, Zhang SQ, Zhang JH, Chen JG, Wang GC, Chen ZS, Han CH. Shi ZD, et al. Mol Cancer. 2022 Feb 7;21(1):37. doi: 10.1186/s12943-022-01517-9. Mol Cancer. 2022. PMID: 35130920 Free PMC article.
We performed genome-wide CRISPR screening in T24 cancer cells in vitro, and identified that the gene heterogeneous nuclear ribonucleoprotein U (HNRNPU) was the top candidate gene related to cisplatin resistance. ...
We performed genome-wide CRISPR screening in T24 cancer cells in vitro, and identified that the gene heterogeneous nuclear …
Deacetylation of HnRNP U mediated by sirtuin1 ameliorates aged rat with liver fibrosis via inhibiting p53-related senescence and NLRP3-related inflammation.
Liu J, Ma X, Guo W, Lu B, Yue Y, Yang X, Wang R, Wu C, Zhang B, Li X, Luo X. Liu J, et al. Int Immunopharmacol. 2024 Nov 15;141:113026. doi: 10.1016/j.intimp.2024.113026. Epub 2024 Aug 30. Int Immunopharmacol. 2024. PMID: 39216234
Silencing HnRNP U reduced H(2)O(2)-induced up-regulation expression of p53, p21, and NLRP3 inflammasome at protein levels. Additionally, H(2)O(2) induced high acetylation of HnRNP U in senescent hepatocytes, whereas overexpressing SIRT1 with adenoviral …
Silencing HnRNP U reduced H(2)O(2)-induced up-regulation expression of p53, p21, and NLRP3 inflammasome at protein levels. Add …
SAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain.
Edson AJ, Jacobsen RG, Lewis AE. Edson AJ, et al. MicroPubl Biol. 2023 Mar 24;2023:10.17912/micropub.biology.000761. doi: 10.17912/micropub.biology.000761. eCollection 2023. MicroPubl Biol. 2023. PMID: 37038481 Free PMC article.
Using quantitative interactomics, we have previously identified PPIn-interacting proteins with roles in RNA processing/splicing including the heterogeneous nuclear ribonucleoprotein U (hnRNPU/SAF-A). In this study, hnRNPU was validated as a direct PPIn …
Using quantitative interactomics, we have previously identified PPIn-interacting proteins with roles in RNA processing/splicing including th …
269 results