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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
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1979 1
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1986 1
1988 1
1989 3
1990 5
1991 2
1992 2
1993 6
1994 5
1995 5
1996 8
1997 12
1998 8
1999 6
2000 7
2001 12
2002 24
2003 21
2004 30
2005 31
2006 40
2007 53
2008 93
2009 82
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2011 98
2012 132
2013 147
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4,151 results

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Page 1
Arginase: An emerging and promising therapeutic target for cancer treatment.
Niu F, Yu Y, Li Z, Ren Y, Li Z, Ye Q, Liu P, Ji C, Qian L, Xiong Y. Niu F, et al. Biomed Pharmacother. 2022 May;149:112840. doi: 10.1016/j.biopha.2022.112840. Epub 2022 Mar 19. Biomed Pharmacother. 2022. PMID: 35316752 Free article. Review.
Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-ornithine. Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in v …
Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-ornithine. Increasing number of studies …
Reply to Niu and Drain.
Anderson PL, Marzinke MA, Glidden DV. Anderson PL, et al. Clin Infect Dis. 2024 Mar 20;78(3):802-803. doi: 10.1093/cid/ciad486. Clin Infect Dis. 2024. PMID: 37586097 Free PMC article. No abstract available.
[Advances in the biosynthesis of L-homoserine and its derivatives by metabolic engineering of Escherichia coli].
Niu K, Gao L, Ge L, Liu Z, Zheng Y. Niu K, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Dec 25;38(12):4385-4402. doi: 10.13345/j.cjb.220377. Sheng Wu Gong Cheng Xue Bao. 2022. PMID: 36593184 Free article. Review. Chinese.
L-homoserine and its derivatives (O-succinyl-L-homoserine and O-acetyl-L-homoserine) are precursors for the biosynthesis of L-methionine, and various C4 compounds (isobutanol, gamma-butyrolactone, 1, 4-butanediol, 2, 4-dihydroxybutyric acid) and L …
L-homoserine and its derivatives (O-succinyl-L-homoserine and O-acetyl-L-homoserine) are precursors for the biosynthesi …
Metabolic engineering for the production of l-phenylalanine in Escherichia coli.
Liu X, Niu H, Li Q, Gu P. Liu X, et al. 3 Biotech. 2019 Mar;9(3):85. doi: 10.1007/s13205-019-1619-6. Epub 2019 Feb 15. 3 Biotech. 2019. PMID: 30800596 Free PMC article. Review.
Microbial production of l-phenylalanine has become attractive as it possesses the advantages of environmental friendliness, low cost, and feedstock renewability. ...In this review, successful metabolic engineering strategies for increasing l-phenylalanine accumulati …
Microbial production of l-phenylalanine has become attractive as it possesses the advantages of environmental friendliness, low cost, …
Metabolic engineering for improving L-tryptophan production in Escherichia coli.
Niu H, Li R, Liang Q, Qi Q, Li Q, Gu P. Niu H, et al. J Ind Microbiol Biotechnol. 2019 Jan;46(1):55-65. doi: 10.1007/s10295-018-2106-5. Epub 2018 Nov 13. J Ind Microbiol Biotechnol. 2019. PMID: 30426284 Review.
However, challenges remain for L-tryptophan biosynthesis to be cost-competitive. In this review, successful and applicable strategies derived from metabolic engineering for increasing L-tryptophan accumulation in E. coli are summarized. In addition, perspectives for …
However, challenges remain for L-tryptophan biosynthesis to be cost-competitive. In this review, successful and applicable strategies …
L-Cysteine-Modified Transfersomes for Enhanced Epidermal Delivery of Podophyllotoxin.
Niu J, Yuan M, Chen J, Wang L, Qi Y, Bai K, Fan Y, Gao P. Niu J, et al. Molecules. 2023 Jul 28;28(15):5712. doi: 10.3390/molecules28155712. Molecules. 2023. PMID: 37570682 Free PMC article.
The purpose of this study was to evaluate L-cysteine-modified transfersomes as the topical carrier for enhanced epidermal delivery of podophyllotoxin (POD). L-cysteine-deoxycholic acid (LC-DCA) conjugate was synthesized via an amidation reaction. ...
The purpose of this study was to evaluate L-cysteine-modified transfersomes as the topical carrier for enhanced epidermal delivery of …
High-Level Production of l-Methionine by Dynamic Deregulation of Metabolism with Engineered Nonauxotroph Escherichia coli.
Niu K, Fu Q, Mei ZL, Ge LR, Guan AQ, Liu ZQ, Zheng YG. Niu K, et al. ACS Synth Biol. 2023 Feb 17;12(2):492-501. doi: 10.1021/acssynbio.2c00481. Epub 2023 Jan 26. ACS Synth Biol. 2023. PMID: 36701126
In addition, the central metabolic pathway and l-cysteine catabolism pathway were further modified to promote the cell growth and enhance the l-methionine production. Finally, the l-methionine fermentation yield in a 5 L bioreactor reached 17.74 g/L …
In addition, the central metabolic pathway and l-cysteine catabolism pathway were further modified to promote the cell growth and enh …
Side-Functionalization of Poly(l-methionine) for Ice Control.
Niu Q, Shang K, Han H, Chen B, Zhu K, Ren L, Yuan X. Niu Q, et al. Biomacromolecules. 2025 Apr 14;26(4):2625-2636. doi: 10.1021/acs.biomac.5c00086. Epub 2025 Mar 14. Biomacromolecules. 2025. PMID: 40084906
Inspired by structures of natural antifreeze (glyco)proteins, in this work, functionalized poly(l-methionine)s (PMets) are synthesized with different side groups including hydroxyl, threonine-mimetic with both methyl and hydroxyl groups (PMet-MOH), zwitterion with carboxyl …
Inspired by structures of natural antifreeze (glyco)proteins, in this work, functionalized poly(l-methionine)s (PMets) are synthesize …
4,151 results