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Year Number of Results
1997 1
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23 results

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Page 1
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain.
Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Tang M, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H; PsychENCODE Consortium†; Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ; PsychENCODE Consortium. Wen C, et al. Science. 2024 May 24;384(6698):eadh0829. doi: 10.1126/science.adh0829. Epub 2024 May 24. Science. 2024. PMID: 38781368 Free PMC article.
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus.
Pellerin D, Del Gobbo GF, Couse M, Dolzhenko E, Nageshwaran SK, Cheung WA, Xu IRL, Dicaire MJ, Spurdens G, Matos-Rodrigues G, Stevanovski I, Scriba CK, Rebelo A, Roth V, Wandzel M, Bonnet C, Ashton C, Agarwal A, Peter C, Hasson D, Tsankova NM, Dewar K, Lamont PJ, Laing NG, Renaud M, Houlden H, Synofzik M, Usdin K, Nussenzweig A, Napierala M, Chen Z, Jiang H, Deveson IW, Ravenscroft G, Akbarian S, Eberle MA, Boycott KM, Pastinen T; All of Us Research Program Long Read Working Group; Brais B, Zuchner S, Danzi MC. Pellerin D, et al. Nat Genet. 2024 Jul;56(7):1366-1370. doi: 10.1038/s41588-024-01808-5. Epub 2024 Jun 27. Nat Genet. 2024. PMID: 38937606 Free PMC article.
Mapping recurrent mosaic copy number variation in human neurons.
Sun C, Kathuria K, Emery SB, Kim B, Burbulis IE, Shin JH; Brain Somatic Mosaicism Network; Weinberger DR, Moran JV, Kidd JM, Mills RE, McConnell MJ. Sun C, et al. Nat Commun. 2024 May 17;15(1):4220. doi: 10.1038/s41467-024-48392-0. Nat Commun. 2024. PMID: 38760338 Free PMC article.
Epigenetic-genetic chromatin footprinting identifies novel and subject-specific genes active in prefrontal cortex neurons.
Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Goltsov AY, Solovyev V, Brizgalov L, Filippova E, Weng Z, Akbarian S, Rogaev EI. Gusev FE, et al. FASEB J. 2019 Jul;33(7):8161-8173. doi: 10.1096/fj.201802646R. Epub 2019 Apr 10. FASEB J. 2019. PMID: 30970224 Free PMC article.
P., Fedonin, G., Halene, T., Aliseychik, M., Goltsov, A. Y., Solovyev, V., Brizgalov, L., Filippova, E., Weng, Z., Akbarian, S., Rogaev, E. ...
P., Fedonin, G., Halene, T., Aliseychik, M., Goltsov, A. Y., Solovyev, V., Brizgalov, L., Filippova, E., Weng, Z., Akbarian, S …
Somatic instability of the FGF14-SCA27B GAA•TTC repeat reveals a marked expansion bias in the cerebellum.
Pellerin D, Méreaux JL, Boluda S, Danzi MC, Dicaire MJ, Davoine CS, Genis D, Spurdens G, Ashton C, Hammond JM, Gerhart BJ, Chelban V, Le PU, Safisamghabadi M, Yanick C, Lee H, Nageshwaran SK, Matos-Rodrigues G, Jaunmuktane Z, Petrecca K, Akbarian S, Nussenzweig A, Usdin K, Renaud M, Bonnet C, Ravenscroft G, Saporta MA, Napierala JS, Houlden H, Deveson IW, Napierala M, Brice A, Molina Porcel L, Seilhean D, Zuchner S, Durr A, Brais B. Pellerin D, et al. Brain. 2025 Apr 3;148(4):1258-1270. doi: 10.1093/brain/awae312. Brain. 2025. PMID: 39378335 Free PMC article.
Altered tRNA expression profile associated with codon-specific proteomic changes in the suicide brain.
Blaze J, Chen S, Heissel S, Alwaseem H, Landinez Macias MP, Peter C, Molina H, Storkebaum E, Turecki G, Goodarzi H, Akbarian S. Blaze J, et al. Mol Psychiatry. 2025 Jul;30(7):2871-2879. doi: 10.1038/s41380-025-02891-8. Epub 2025 Jan 14. Mol Psychiatry. 2025. PMID: 39809846 Free PMC article.
Transfer (t)RNAs and their modifications, including cytosine methylation (m(5)C), have received little attention regarding their role in normal or diseased brain function, though they are dynamic mediators of protein synthesis. tRNA regulation is highly interconnected with …
Transfer (t)RNAs and their modifications, including cytosine methylation (m(5)C), have received little attention regarding their role …
Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.
Chou MY, Cao X, Hou KC, Tsai MH, Lee CY, Kuo MF, Wu VC, Huang HY, Akbarian S, Chang SK, Hu CY, Lin SW, Huang HS. Chou MY, et al. Commun Biol. 2023 Mar 14;6(1):267. doi: 10.1038/s42003-023-04655-y. Commun Biol. 2023. PMID: 36918719 Free PMC article.
Here we show paternal, but not maternal, expression of MIR125B2 in human but not mouse brain. Moreover, Mir125b-2(m)(-)(/p)(-) mice showed impaired learning and memory, and anxiety, whose functions were hippocampus-dependent. Hippocampal granule cells from Mir125b-2(m …
Here we show paternal, but not maternal, expression of MIR125B2 in human but not mouse brain. Moreover, Mir125b-2(m)(-)(/p)(-) mice s …
tRNA epitranscriptomic alterations associated with opioid-induced reward-seeking and long-term opioid withdrawal in male mice.
Blaze J, Browne CJ, Futamura R, Javidfar B, Zachariou V, Nestler EJ, Akbarian S. Blaze J, et al. Neuropsychopharmacology. 2024 Jul;49(8):1276-1284. doi: 10.1038/s41386-024-01813-6. Epub 2024 Feb 8. Neuropsychopharmacology. 2024. PMID: 38332016 Free PMC article.
Here, we probed whether chronic morphine exposure could alter tRNA cytosine methylation (m(5)C) and resulting expression levels in the medial prefrontal cortex (mPFC), a brain region crucial for reward processing and executive function that exhibits opioid-induced molecula …
Here, we probed whether chronic morphine exposure could alter tRNA cytosine methylation (m(5)C) and resulting expression levels in th …
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
Blaze J, Navickas A, Phillips HL, Heissel S, Plaza-Jennings A, Miglani S, Asgharian H, Foo M, Katanski CD, Watkins CP, Pennington ZT, Javidfar B, Espeso-Gil S, Rostandy B, Alwaseem H, Hahn CG, Molina H, Cai DJ, Pan T, Yao WD, Goodarzi H, Haghighi F, Akbarian S. Blaze J, et al. Nat Commun. 2021 Aug 13;12(1):4913. doi: 10.1038/s41467-021-24969-x. Nat Commun. 2021. PMID: 34389722 Free PMC article.
Neuronal Nsun2-deficiency was associated with a decrease in tRNA m(5)C levels, resulting in deficits in expression of 70% of tRNA(Gly) isodecoders. Altogether, 1488/5820 proteins changed upon neuronal Nsun2-deficiency, in conjunction with glycine codon-specific defects in …
Neuronal Nsun2-deficiency was associated with a decrease in tRNA m(5)C levels, resulting in deficits in expression of 70% of tRNA(Gly …
23 results