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50 results

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Page 1
Amyloid-Driven Allostery.
Garcha J, Huang J, Martinez Pomier K, Melacini G. Garcha J, et al. Among authors: melacini g. Biophys Chem. 2024 Dec;315:107320. doi: 10.1016/j.bpc.2024.107320. Epub 2024 Aug 30. Biophys Chem. 2024. PMID: 39278064 Free article. Review.
Allosteric pluripotency: challenges and opportunities.
Akimoto M, Martinez Pomier K, VanSchouwen B, Byun JA, Khamina M, Melacini G. Akimoto M, et al. Among authors: melacini g. Biochem J. 2022 Apr 14;479(7):825-838. doi: 10.1042/BCJ20210528. Biochem J. 2022. PMID: 35403669
Non-Canonical Allostery in Cyclic Nucleotide Dependent Kinases.
Khamina M, Martinez Pomier K, Akimoto M, VanSchouwen B, Melacini G. Khamina M, et al. Among authors: melacini g. J Mol Biol. 2022 Sep 15;434(17):167584. doi: 10.1016/j.jmb.2022.167584. Epub 2022 Apr 12. J Mol Biol. 2022. PMID: 35427632 Review.
The cAMP- and cGMP-dependent protein kinases (PKA and PKG) are canonically activated by the corresponding cyclic nucleotides. ...
The cAMP- and cGMP-dependent protein kinases (PKA and PKG) are canonically activated by the corresponding cyclic nucleotides. ...
Allosteric linkers in cAMP signalling.
Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Akimoto M, et al. Among authors: melacini g. Biochem Soc Trans. 2014 Feb;42(1):139-44. doi: 10.1042/BST20130257. Biochem Soc Trans. 2014. PMID: 24450641 Free PMC article. Review.
Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective.
Ahmed A, Boulton S, Shao H, Akimoto M, Natarajan A, Cheng X, Melacini G. Ahmed A, et al. Among authors: melacini g. Cells. 2019 Nov 19;8(11):1462. doi: 10.3390/cells8111462. Cells. 2019. PMID: 31752286 Free PMC article. Review.
The universal second messenger cAMP regulates diverse intracellular processes by interacting with ubiquitously expressed proteins, such as Protein Kinase A (PKA) and the Exchange Protein directly Activated by cAMP (EPAC). ...
The universal second messenger cAMP regulates diverse intracellular processes by interacting with ubiquitously expressed proteins, su …
Functional dynamics in cyclic nucleotide signaling and amyloid inhibition.
VanSchouwen B, Ahmed R, Milojevic J, Melacini G. VanSchouwen B, et al. Among authors: melacini g. Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1529-1543. doi: 10.1016/j.bbapap.2017.09.005. Epub 2017 Sep 11. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28911813 Review.
Specifically, we will show how NMR was utilized to reveal the dynamical basis of cyclic nucleotide affinity, selectivity, agonism and antagonism in multiple eukaryotic cAMP and cGMP receptors. We will also illustrate how NMR revealed the mechanism of action of plasma prote …
Specifically, we will show how NMR was utilized to reveal the dynamical basis of cyclic nucleotide affinity, selectivity, agonism and antago …
Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides.
VanSchouwen B, Melacini G. VanSchouwen B, et al. Among authors: melacini g. Handb Exp Pharmacol. 2017;238:123-133. doi: 10.1007/164_2016_5006. Handb Exp Pharmacol. 2017. PMID: 28181007 Review.
Although they are regulated primarily by cAMP, other cyclic nucleotides such as cGMP, cCMP, and cUMP serve as partial agonists for the HCN2 and HCN4 isoforms. By competing with cAMP for binding, these non-canonical ligands alter ion channel gating, and in turn, modu …
Although they are regulated primarily by cAMP, other cyclic nucleotides such as cGMP, cCMP, and cUMP serve as partial agonists for th …
QSAR models reveal new EPAC-selective allosteric modulators.
Mohamed H, Shao H, Akimoto M, Darveau P, MacKinnon MR, Magolan J, Melacini G. Mohamed H, et al. Among authors: melacini g. RSC Chem Biol. 2022 Aug 3;3(10):1230-1239. doi: 10.1039/d2cb00106c. eCollection 2022 Oct 5. RSC Chem Biol. 2022. PMID: 36320893 Free PMC article.
Exchange proteins directly activated by cAMP (EPAC) are guanine nucleotide exchange factors for the small GTPases, Rap1 and Rap2. ...
Exchange proteins directly activated by cAMP (EPAC) are guanine nucleotide exchange factors for the small GTPases, Rap1 and Rap2. ...
cAMP-dependent allostery and dynamics in Epac: an NMR view.
Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G. Selvaratnam R, et al. Among authors: melacini g. Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Biochem Soc Trans. 2012. PMID: 22260694 Review.
Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cAMP signal to the catalysis of guanine exchange in the Rap substrate. ...Such dynamically mediated allosteric effects contribute not only …
Epac (exchange protein directly activated by cAMP) is a critical cAMP receptor, which senses cAMP and couples the cA …
Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.
Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G. Boulton S, et al. Among authors: melacini g. Biochem Soc Trans. 2014 Apr;42(2):302-7. doi: 10.1042/BST20130282. Biochem Soc Trans. 2014. PMID: 24646235 Review.
Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selective cAMP agonism and antagonism. ...In the present article, we specifically address how the highly conserved CBD fold binds cAMP …
Before the full translational potential of cAMP signalling can be tapped, it is critical to understand the structural basis for selec …
50 results