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The following term was not found in PubMed: mirzabegher
Page 1
A brief history of NEDA.
Giovannoni G, Bermel R, Phillips T, Rudick R. Giovannoni G, et al. Mult Scler Relat Disord. 2018 Feb;20:228-230. doi: 10.1016/j.msard.2017.07.011. Epub 2017 Jul 13. Mult Scler Relat Disord. 2018. PMID: 29579628 No abstract available.
No Evidence of Disease Activity (NEDA) as a Clinical Assessment Tool for Multiple Sclerosis: Clinician and Patient Perspectives [Narrative Review].
Newsome SD, Binns C, Kaunzner UW, Morgan S, Halper J. Newsome SD, et al. Neurol Ther. 2023 Dec;12(6):1909-1935. doi: 10.1007/s40120-023-00549-7. Epub 2023 Oct 11. Neurol Ther. 2023. PMID: 37819598 Free PMC article. Review.
We identify current challenges to the use of NEDA in clinical practice and detail the proposed amendments, such as the inclusion of alternative outcomes and biomarkers, to broaden the clinical information captured by NEDA. ...One such outcome is the set of criteria …
We identify current challenges to the use of NEDA in clinical practice and detail the proposed amendments, such as the inclusion of a …
Association of NEDA-4 With No Long-term Disability Progression in Multiple Sclerosis and Comparison With NEDA-3: A Systematic Review and Meta-analysis.
Rotstein D, Solomon JM, Sormani MP, Montalban X, Ye XY, Dababneh D, Muccilli A, Saab G, Shah P. Rotstein D, et al. Neurol Neuroimmunol Neuroinflamm. 2022 Oct 12;9(6):e200032. doi: 10.1212/NXI.0000000000200032. Print 2022 Nov. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 36224046 Free PMC article.
However, the ability of NEDA-4 to discriminate long-term outcomes in MS and how its performance compares with NEDA-3 remain uncertain. ...We conducted a meta-analysis using random-effects model to determine the pooled odds ratio (OR) for no disability progression wi …
However, the ability of NEDA-4 to discriminate long-term outcomes in MS and how its performance compares with NEDA-3 remain un …
Are we in need of NEDA?
Freedman MS. Freedman MS. Mult Scler. 2016 Jan;22(1):5-6. doi: 10.1177/1352458515617249. Epub 2015 Nov 9. Mult Scler. 2016. PMID: 26552731 No abstract available.
NEDA status in highly active MS can be more easily obtained with autologous hematopoietic stem cell transplantation than other drugs.
Sormani MP, Muraro PA, Saccardi R, Mancardi G. Sormani MP, et al. Mult Scler. 2017 Feb;23(2):201-204. doi: 10.1177/1352458516645670. Epub 2016 Jul 11. Mult Scler. 2017. PMID: 27207454 Review.
Achievement of NEDA status in patients receiving a disease-modifying therapy (DMT) seems to be an ambitious but ideal goal for therapies in RRMS. Recently, published post hoc analyses of clinical trials reported percentages of RRMS patients maintaining the NEDA stat …
Achievement of NEDA status in patients receiving a disease-modifying therapy (DMT) seems to be an ambitious but ideal goal for therap …
NEDA treatment target? No evident disease activity as an actionable outcome in practice.
Parks NE, Flanagan EP, Lucchinetti CF, Wingerchuk DM. Parks NE, et al. J Neurol Sci. 2017 Dec 15;383:31-34. doi: 10.1016/j.jns.2017.10.015. Epub 2017 Oct 13. J Neurol Sci. 2017. PMID: 29246616 Review.
NEDA has also been proposed as a treatment goal in clinical care. At this point, the long-term implications of early NEDA remain largely unknown. We review current NEDA definitions, use in clinical trials, and its prospects for routine use as an actionable tr …
NEDA has also been proposed as a treatment goal in clinical care. At this point, the long-term implications of early NEDA rema …
The Comparative Efficacy of Non-ergot Dopamine Agonist and Potential Risk Factors for Motor Complications and Side Effects From NEDA Use in Early Parkinson's Disease: Evidence From Clinical Trials.
Wu C, Guo H, Xu Y, Li L, Li X, Tang C, Chen D, Zhu M. Wu C, et al. Front Aging Neurosci. 2022 Apr 22;14:831884. doi: 10.3389/fnagi.2022.831884. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35527736 Free PMC article.

PD patients treated with NEDA or NEDA+open LD had a lower risk of wearing-off implications than those treated with LD (all p < 0.05). ...CONCLUSION: NEDA therapy reduces motor symptoms and improves ADLs in early PD. The odds of developing motor complicatio

…
PD patients treated with NEDA or NEDA+open LD had a lower risk of wearing-off implications than those treated with LD (all p & …
Beyond Efficacy: Persistence, NEDA, and Therapeutic Decision-Making in First-Line Multiple Sclerosis Treatment.
López-Caneda CH, Antón-Fuente S, Pérez-Haro MJ, Sánchez-Franco CM, Alvarez-Rodríguez E, Aguado-Valcarcel M, Marcos-Bobillo M, Torrente-Carballido M, González-Suárez I. López-Caneda CH, et al. Neurol Ther. 2025 Oct;14(5):2095-2106. doi: 10.1007/s40120-025-00811-0. Epub 2025 Aug 12. Neurol Ther. 2025. PMID: 40794358 Free PMC article.
Effectiveness was evaluated using cumulative no evidence of disease activity (NEDA)-2 and NEDA-3 status. NEDA-2 included the absence of clinical relapses and confirmed disability progression; NEDA-3 additionally required the lack of MRI activity. ...No …
Effectiveness was evaluated using cumulative no evidence of disease activity (NEDA)-2 and NEDA-3 status. NEDA-2 include …
Biomarkers of response to ocrelizumab in relapsing-remitting multiple sclerosis.
Rodríguez-Jorge F, Fernández-Velasco JI, Villarrubia N, Gracia-Gil J, Fernández E, Meca-Lallana V, Díaz-Pérez C, Sainz de la Maza S, Pacheco EM, Quiroga A, Ramió-Torrentà L, Martínez-Yélamos S, Bau L, Monreal E, López-Real A, Rodero-Romero A, Borrega L, Díaz S, Eguía P, Espiño M, Chico-García JL, Barrero FJ, Martínez-Ginés ML, García-Domínguez JM, De la Fuente S, Moreno I, Sainz-Amo R, Mañé-Martínez MA, Caminero A, Castellanos F, Gómez López A, Labiano-Fontcuberta A, Ayuso L, Abreu R, Hernández MÁ, Meca-Lallana J, Martín-Aguilar L, Muriel García A, Masjuan J, Costa-Frossard L, Villar LM. Rodríguez-Jorge F, et al. Front Immunol. 2024 Nov 12;15:1480676. doi: 10.3389/fimmu.2024.1480676. eCollection 2024. Front Immunol. 2024. PMID: 39606235 Free PMC article.

RESULTS: After a year on ocrelizumab, 85 patients (73.9%) achieved NEDA-3. Thirty patients did not achieve NEDA: 20 (17.4%) because of INFL and 10 (8.7%) because of PIRA. ...After a year, NEDA-3 and INFL patients showed similar decreases in sNfL (p < 0.000

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RESULTS: After a year on ocrelizumab, 85 patients (73.9%) achieved NEDA-3. Thirty patients did not achieve NEDA: 20 (17.4%) be …
Prevalence of 2-year "No evidence of disease activity" (NEDA-3 and NEDA-4) in relapsing-remitting multiple sclerosis. A real-world study.
Bazzurri V, Fiore A, Curti E, Tsantes E, Franceschini A, Granella F. Bazzurri V, et al. Mult Scler Relat Disord. 2023 Nov;79:105015. doi: 10.1016/j.msard.2023.105015. Epub 2023 Sep 18. Mult Scler Relat Disord. 2023. PMID: 37769430
NEDA-4 meets all NEDA-3 criteria plus lack of brain atrophy. OBJECTIVE: Aim of this study was to investigate the prevalence of two-year NEDA-3, NEDA-4, six-month delayed NEDA-3 (6mdNEDA-3), and six-month delayed NEDA-4 (6mdNEDA-4) in a co …
NEDA-4 meets all NEDA-3 criteria plus lack of brain atrophy. OBJECTIVE: Aim of this study was to investigate the prevalence of …
1,277 results