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Page 1
Curcumin attenuates hypoxia/reoxygenation-induced cardiomyocyte injury by downregulating Notch signaling.
Zhu P, Yang M, He H, Kuang Z, Liang M, Lin A, Liang S, Wen Q, Cheng Z, Sun C. Zhu P, et al. Mol Med Rep. 2019 Aug;20(2):1541-1550. doi: 10.3892/mmr.2019.10371. Epub 2019 Jun 10. Mol Med Rep. 2019. PMID: 31257466 Free PMC article.
ROS levels in H/R-induced cells were also significantly downregulated by curcumin treatment (P<0.01), and the apoptotic rate was significantly decreased from 15.13% in the H/R group to 7.7% in the H/R + curcumin group (P<0.01). ...The present study indi …
ROS levels in H/R-induced cells were also significantly downregulated by curcumin treatment (P<0.01), and the apoptotic rat …
Retraction.
[No authors listed] [No authors listed] Cancer. 2016 Oct 15;122(20):3247. doi: 10.1002/cncr.30216. Epub 2016 Jul 29. Cancer. 2016. PMID: 27696400 Free article.
Retraction: "Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells" by Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. ...REFERENCES: Wang, Z., Zhang, Y., Banerjee, …
Retraction: "Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induct …
Curcumin inhibits lipopolysaccharide-induced proximal renal tubular epithelial cell death by regulating ADAMTS18 methylation and AKT/Notch pathways.
Xu B, Zhang JE, Ye L, Yuan CW. Xu B, et al. Arch Med Sci. 2023 Jun 11;19(6):1822-1831. doi: 10.5114/aoms/167396. eCollection 2023. Arch Med Sci. 2023. PMID: 38058716 Free PMC article.
After siADAMTS18, the ability of curcumin to improve cell viability was reduced, and the ability of curcumin to downregulate inflammatory factors was significantly reduced. Curcumin could also inhibit the expression of AKT, Notch-1 and Notch …
After siADAMTS18, the ability of curcumin to improve cell viability was reduced, and the ability of curcumin to downregulat …
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells.
Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. Wang Z, et al. Cancer. 2006 Jun 1;106(11):2503-13. doi: 10.1002/cncr.21904. Cancer. 2006. Retraction in: Cancer. 2016 Oct 15;122(20):3247. doi: 10.1002/cncr.30216. PMID: 16628653 Free article. Retracted.
Therefore, the down-regulation of Notch signaling may be a novel approach for pancreatic cancer therapy. ...These results suggest that the down-regulation of Notch signaling by curcumin may be a novel strategy for the treatment of …
Therefore, the down-regulation of Notch signaling may be a novel approach for pancreatic cancer therapy. ...These resul …
Effects of Notch Signaling Pathway in Cervical Cancer by Curcumin Mediated Photodynamic Therapy and Its Possible Mechanisms in Vitro and in Vivo.
He G, Mu T, Yuan Y, Yang W, Zhang Y, Chen Q, Bian M, Pan Y, Xiang Q, Chen Z, Sun A. He G, et al. J Cancer. 2019 Jul 10;10(17):4114-4122. doi: 10.7150/jca.30690. eCollection 2019. J Cancer. 2019. PMID: 31417656 Free PMC article.
This effect can effectively block the conduction of Notch signaling pathway, which is associated with down-regulation of the expression of Notch1 and NF-kappaB. Notch signaling pathway could be one of the targets of curcumin-PDT photodynamic the …
This effect can effectively block the conduction of Notch signaling pathway, which is associated with down-regulation o …
Curcumin induces G0/G1 arrest and apoptosis in hormone independent prostate cancer DU-145 cells by down regulating Notch signaling.
Sha J, Li J, Wang W, Pan L, Cheng J, Li L, Zhao H, Lin W. Sha J, et al. Biomed Pharmacother. 2016 Dec;84:177-184. doi: 10.1016/j.biopha.2016.09.037. Epub 2016 Sep 19. Biomed Pharmacother. 2016. PMID: 27657825
In order to study whether Notch 1 expression could be downregulated by curcumin, Notch 1 siRNA and Notch 1 plasmid were used in Notch 1 down-regulation and over-expression. ...RESULTS: We found that Notch 1 signaling …
In order to study whether Notch 1 expression could be downregulated by curcumin, Notch 1 siRNA and Notch …
Curcumin suppresses Notch-1 signaling: Improvements in fatty liver and insulin resistance in rats.
Zhao NJ, Liao MJ, Wu JJ, Chu KX. Zhao NJ, et al. Mol Med Rep. 2018 Jan;17(1):819-826. doi: 10.3892/mmr.2017.7980. Epub 2017 Nov 6. Mol Med Rep. 2018. PMID: 29115530 Free PMC article.
However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction pathway involved in energy metabolism. The present study aimed to investigate the effects of curcumin administration on glucose-lipi …
However, the exact molecular mechanisms underlying this process have yet to be determined. The Notch pathway is a signal transduction …
Curcumin inhibits proliferation and invasion of osteosarcoma cells through inactivation of Notch-1 signaling.
Li Y, Zhang J, Ma D, Zhang L, Si M, Yin H, Li J. Li Y, et al. FEBS J. 2012 Jun;279(12):2247-59. doi: 10.1111/j.1742-4658.2012.08607.x. Epub 2012 May 21. FEBS J. 2012. PMID: 22521131 Free article.
We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in enhanced inhibition of cell growth and invasion. ...Our data provide the first evidence that the downregulation of Notch-1 by …
We also found that specific downregulation of Notch-1 via small-interfering RNA prior to curcumin treatment resulted in …
Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling.
Subramaniam D, Ponnurangam S, Ramamoorthy P, Standing D, Battafarano RJ, Anant S, Sharma P. Subramaniam D, et al. PLoS One. 2012;7(2):e30590. doi: 10.1371/journal.pone.0030590. Epub 2012 Feb 17. PLoS One. 2012. PMID: 22363450 Free PMC article.
Furthermore, curcumin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1. This reduction in Notch-1 activation was determined to be due to the down-regulation of critical components of the gamma-s …
Furthermore, curcumin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1. Thi …
Nanocurcumin Inhibits Angiogenesis via Down-regulating hif1a/VEGF-A Signaling in Zebrafish.
Cao Z, He S, Peng Y, Liao X, Lu H. Cao Z, et al. Curr Neurovasc Res. 2020;17(2):147-154. doi: 10.2174/1567202617666200207130039. Curr Neurovasc Res. 2020. PMID: 32031071
This offers promise for the therapeutic effectiveness of curcumin by increasing its bioavailability, solubility and retention time. METHODS: Here, we compared the medicinal effectiveness of curcumin and nanocurcumin (NC), and found that nanocurcumin can inhibit angi …
This offers promise for the therapeutic effectiveness of curcumin by increasing its bioavailability, solubility and retention time. M …
36 results