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Page 1
Drugs for bipolar disorder.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2024 Apr 1;66(1699):49-54. doi: 10.58347/tml.2024.1699a. Med Lett Drugs Ther. 2024. PMID: 38576143 No abstract available.
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP3A4 and CYP1A2 and antipsychotics.
Beunk L, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Swen JJ, Touw D, van Westrhenen R, Deneer VHM, van der Weide J. Beunk L, et al. Eur J Hum Genet. 2024 Mar;32(3):278-285. doi: 10.1038/s41431-023-01347-3. Epub 2023 Mar 31. Eur J Hum Genet. 2024. PMID: 37002327
The DPWG identified gene-drug interactions that require therapy adjustments when respective genotype is known for CYP2D6 with aripiprazole, brexpiprazole, haloperidol, pimozide, risperidone and zuclopenthixol, and for CYP3A4 with quetiapine. ...For identified gene- …
The DPWG identified gene-drug interactions that require therapy adjustments when respective genotype is known for CYP2D6 with …
Management of serotonin syndrome (toxicity).
Chiew AL, Isbister GK. Chiew AL, et al. Br J Clin Pharmacol. 2024 Jun 26. doi: 10.1111/bcp.16152. Online ahead of print. Br J Clin Pharmacol. 2024. PMID: 38926083 Review. French.
Serotonin syndrome (toxicity), resulting from an excessive accumulation of serotonin in the central nervous system, it can occur due to various factors such as the initiation of medication, overdose or drug interactions. Diagnosing serotonin toxicity presents challe …
Serotonin syndrome (toxicity), resulting from an excessive accumulation of serotonin in the central nervous system, it can occur due to vari …
Effects of Antipsychotic Medication on Brain Structure in Patients With Major Depressive Disorder and Psychotic Features: Neuroimaging Findings in the Context of a Randomized Placebo-Controlled Clinical Trial.
Voineskos AN, Mulsant BH, Dickie EW, Neufeld NH, Rothschild AJ, Whyte EM, Meyers BS, Alexopoulos GS, Hoptman MJ, Lerch JP, Flint AJ. Voineskos AN, et al. JAMA Psychiatry. 2020 Jul 1;77(7):674-683. doi: 10.1001/jamapsychiatry.2020.0036. JAMA Psychiatry. 2020. PMID: 32101271 Free PMC article. Clinical Trial.

There was a significant treatment-group by time interaction in cortical thickness (left, t = 3.3; P = .001; right, t = 3.6; P < .001) but not surface area. No significant interaction was found for fractional anisotropy, but one for mean diffusivity of the white m

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There was a significant treatment-group by time interaction in cortical thickness (left, t = 3.3; P = .001; right, t = 3.6; P < .0

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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis.
Guo LK, Su Y, Zhang YY, Yu H, Lu Z, Li WQ, Yang YF, Xiao X, Yan H, Lu TL, Li J, Liao YD, Kang ZW, Wang LF, Li Y, Li M, Liu B, Huang HL, Lv LX, Yao Y, Tan YL, Breen G, Everall I, Wang HX, Huang Z, Zhang D, Yue WH. Guo LK, et al. Mil Med Res. 2023 Jun 2;10(1):24. doi: 10.1186/s40779-023-00459-7. Mil Med Res. 2023. PMID: 37269009 Free PMC article.
BACKGROUND: Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly variable and difficult to predict due to the lack of effective biomarkers. ...The study also examine …
BACKGROUND: Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as …
P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats.
Xu Y, Lu J, Yao B, Zhang Y, Huang S, Liu J, Zhang Y, Guo Y, Wang X. Xu Y, et al. Toxicol Appl Pharmacol. 2021 Nov 15;431:115735. doi: 10.1016/j.taap.2021.115735. Epub 2021 Oct 2. Toxicol Appl Pharmacol. 2021. PMID: 34610281
Clinical trials of olanzapine combined with fluoxetine (Olanzapine/Fluoxetine Combination, OFC) in the treatment of refractory depression have shown significant efficacy, but the drug-drug interaction (DDI) between them remains unclear. In this …
Clinical trials of olanzapine combined with fluoxetine (Olanzapine/Fluoxetine Combination, OFC) in the treatment of refractory …
The effect of vortioxetine on anhedonia in patients with schizophrenia.
Greš A, Šagud M, Dickov A. Greš A, et al. Int J Psychiatry Med. 2024 Mar;59(2):139-152. doi: 10.1177/00912174231199925. Epub 2023 Aug 30. Int J Psychiatry Med. 2024. PMID: 37647498 Clinical Trial.

FINDINGS: Vortioxetine treatment had a significant effect on level of physical anhedonia. The treatment interaction was also statistically significant, but with a relatively small effect (F = 3.17, P < .05; eta2 = .061). ...CONCLUSION: The combination of olanzapine

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FINDINGS: Vortioxetine treatment had a significant effect on level of physical anhedonia. The treatment interaction was also statisti …
Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5-HT(2A) and D(2) receptor interaction pathways.
Islam MT, Chowdhury R, Bhuia MS, Chakrabarty B, Kundu N, Akbor MS, Sheikh S, Chowdhury RI, Ansari SA, Ansari IA, Islam MA. Islam MT, et al. Drug Dev Res. 2024 Sep;85(6):e22259. doi: 10.1002/ddr.22259. Drug Dev Res. 2024. PMID: 39233388
For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows: control (vehicle), DZN-1.25, DZN-2.5, DZN-5 mg/kg, olanzapine (OLN)-2, and a combination of DZN-1.25 with OLN-2. Additionally, in silico …
For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows: con …
[Smoking cessation and drug interactions].
Madsen HKL, Gulløv M, Farver-Vestergaard I, Hjort P, Nielsen LP, Løkke A, Haastrup MB. Madsen HKL, et al. Ugeskr Laeger. 2022 Aug 29;184(35):V02220117. Ugeskr Laeger. 2022. PMID: 36065858 Free article. Danish.
Tobacco smoke can cause drug interactions by induction of CYP1A2, which metabolizes drugs like clozapine, olanzapine and theophylline. ...Of the drugs used for smoking cessation only bupropione has clinically relevant interactions. All of these situati …
Tobacco smoke can cause drug interactions by induction of CYP1A2, which metabolizes drugs like clozapine, olanzapine an …
Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies.
Huang Y, Qiu F, Habgood M, Nie S, Dziegielewska K, Saunders N. Huang Y, et al. F1000Res. 2022 Dec 2;11:1417. doi: 10.12688/f1000research.128074.2. eCollection 2022. F1000Res. 2022. PMID: 36798113 Free PMC article.
Results: Olanzapine entry into brain and CSF was not age-dependent. Prolonged olanzapine treatment reduced placental transfer from 53% to 46% (p<0.05). ...Repeated co-treatment of digoxin and olanzapine increased olanzapine transfer into the brain a …
Results: Olanzapine entry into brain and CSF was not age-dependent. Prolonged olanzapine treatment reduced placental transfer …
63 results