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Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease.
Ferrari R, Xie B, Assaf E, Morder K, Scott M, Liao H, Calderon MJ, Ross M, Loughran P, Watkins SC, Pipinos I, Casale G, Tzeng E, McEnaney R, Sachdev U. Ferrari R, et al. Cells. 2022 Mar 30;11(7):1163. doi: 10.3390/cells11071163. Cells. 2022. PMID: 35406727 Free PMC article.
Inhibition of caspase activity deterred differentiation in ischemic but not perfused myoblasts and reduced the release of HMGB1 from both groups. Conclusion: Inflammatory caspases can be activated in ischemic myoblasts by AIM2 and influence ischemic myoblast differentiatio …
Inhibition of caspase activity deterred differentiation in ischemic but not perfused myoblasts and reduced the release of HMGB1 from …
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
Wu CC, Chang CY, Tzeng CY, Huang JH, Hung CJ, Chen WY, Liao SL, Kuan YH, Chen CJ. Wu CC, et al. Int J Mol Sci. 2022 Jun 28;23(13):7197. doi: 10.3390/ijms23137197. Int J Mol Sci. 2022. PMID: 35806200 Free PMC article.
We further identified that the Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappaB inflammatory axes may each play pivotal roles in the acquisition of microglia M1 polarization and pro …
We further identified that the Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1) …
Systemic vasoprotection by inhaled carbon monoxide is mediated through prolonged alterations in monocyte/macrophage function.
Leake A, Salem K, Madigan MC, Lee GR, Shukla A, Hong G, Zuckerbraun BS, Tzeng E. Leake A, et al. Nitric Oxide. 2020 Jan 1;94:36-47. doi: 10.1016/j.niox.2019.10.003. Epub 2019 Oct 5. Nitric Oxide. 2020. PMID: 31593762 Free PMC article.
This effect was mediated by Mphi released VEGF and HMGB1. Inhaled CO reduced LPS induced Mphi M1 inflammatory phenotype for up to 5 days. ...
This effect was mediated by Mphi released VEGF and HMGB1. Inhaled CO reduced LPS induced Mphi M1 inflammatory phenotype for up to 5 d …
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
Xu J, Cui X, Li J, Koutakis P, Pipinos I, Tzeng E, Chen A, Sachdev U. Xu J, et al. J Vasc Surg. 2018 Mar;67(3):910-921. doi: 10.1016/j.jvs.2017.01.021. Epub 2017 Mar 1. J Vasc Surg. 2018. PMID: 28259568 Free PMC article.
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves angiogenesis after tissue ischemia. Antagonizing HMGB1 prolongs muscle necrosis and deters regeneration. ...Clinical symptoms and ankl …
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves a …
HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer.
Huang BF, Tzeng HE, Chen PC, Wang CQ, Su CM, Wang Y, Hu GN, Zhao YM, Wang Q, Tang CH. Huang BF, et al. Int J Med Sci. 2018 Mar 12;15(6):580-586. doi: 10.7150/ijms.23462. eCollection 2018. Int J Med Sci. 2018. PMID: 29725248 Free PMC article.
HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. ...Our results indicate that genetic …
HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association …
HMGB1 and TLR4 mediate skeletal muscle recovery in a murine model of hindlimb ischemia.
Sachdev U, Cui X, Tzeng E. Sachdev U, et al. J Vasc Surg. 2013 Aug;58(2):460-9. doi: 10.1016/j.jvs.2012.11.071. Epub 2013 Feb 12. J Vasc Surg. 2013. PMID: 23414695 Free PMC article.
BACKGROUND: We have previously shown that the danger signal high-mobility group box 1 (HMGB1) promotes angiogenesis when administered to ischemic muscle. HMGB1 signals through Toll-like receptor 4 (TLR4) as well as the receptor for advanced glycation end-products (R …
BACKGROUND: We have previously shown that the danger signal high-mobility group box 1 (HMGB1) promotes angiogenesis when administered …
TLR2 and TLR4 mediate differential responses to limb ischemia through MyD88-dependent and independent pathways.
Sachdev U, Cui X, McEnaney R, Wang T, Benabou K, Tzeng E. Sachdev U, et al. PLoS One. 2012;7(11):e50654. doi: 10.1371/journal.pone.0050654. Epub 2012 Nov 29. PLoS One. 2012. PMID: 23209800 Free PMC article.
INTRODUCTION: The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischemia. HMGB1 is a ligand for innate immune receptors TLR2 and TLR4. While both TLR2 and TLR4 signal through myeloid differentiation fact …
INTRODUCTION: The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischem …
Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes.
Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. Tzeng HP, et al. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1490-6. doi: 10.1152/ajpheart.00910.2007. Epub 2008 Jan 25. Am J Physiol Heart Circ Physiol. 2008. PMID: 18223193 Free PMC article.
The immediate negative inotropic effects of HMGB1 on cell contractility and calcium homeostasis were partially reversible upon washout of HMGB1. A significant inhibition of the inward l-type calcium currents was also documented by the patch-clamp technique. HMGB1 …
The immediate negative inotropic effects of HMGB1 on cell contractility and calcium homeostasis were partially reversible upon washou …
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury.
Sachdev U, Cui X, Hong G, Namkoong S, Karlsson JM, Baty CJ, Tzeng E. Sachdev U, et al. J Vasc Surg. 2012 Jan;55(1):180-91. doi: 10.1016/j.jvs.2011.07.072. Epub 2011 Sep 23. J Vasc Surg. 2012. PMID: 21944908 Free PMC article.
HMGB1 treatment of ECs enhanced tube formation, an angiogenic phenotype of ECs. Neutralization of endogenous HMGB1 markedly impaired tube formation and inhibited LC3II formation. ...CONCLUSIONS: Nuclear release of HMGB1 and autophagy occur in ECs in response …
HMGB1 treatment of ECs enhanced tube formation, an angiogenic phenotype of ECs. Neutralization of endogenous HMGB1 markedly im …
TLR4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 (TLR2) in Ischemic Skeletal Muscle and Endothelial Cells.
Xu J, Benabou K, Cui X, Madia M, Tzeng E, Billiar T, Watkins S, Sachdev U. Xu J, et al. Mol Med. 2015 Jul 14;21(1):605-15. doi: 10.2119/molmed.2014.00260. Mol Med. 2015. PMID: 26181630 Free PMC article.
TLR2 also mediated EC permeability, an initial step during angiogenesis, in response to high-mobility group box-1 (HMGB1) that is released by cells during hypoxic injury. In vivo, ischemia-induced upregulation of TLR2 required intact TLR4 signaling that mediated systemic i …
TLR2 also mediated EC permeability, an initial step during angiogenesis, in response to high-mobility group box-1 (HMGB1) that is rel …