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Inflammatory Caspase Activity Mediates HMGB1 Release and Differentiation in Myoblasts Affected by Peripheral Arterial Disease.
Ferrari R, Xie B, Assaf E, Morder K, Scott M, Liao H, Calderon MJ, Ross M, Loughran P, Watkins SC, Pipinos I, Casale G, Tzeng E, McEnaney R, Sachdev U. Ferrari R, et al. Cells. 2022 Mar 30;11(7):1163. doi: 10.3390/cells11071163. Cells. 2022. PMID: 35406727 Free PMC article.
METHODS: Caspase activity was measured in ischemic and perfused human myoblasts in response to the NLRP3 and AIM2 inflammasome agonists (nigericin and poly(dA:dT), respectively) with and without specific caspase-1 or pan-caspase inhibition. mRNA levels of myogenic markers …
METHODS: Caspase activity was measured in ischemic and perfused human myoblasts in response to the NLRP3 and AIM2 inflammasome agonists (nig …
Preventive Intrathecal Injection of Bupivacaine Alleviated Microglia Activation and Neuropathic Pain in a Rat Model of Chronic Constriction Injury.
Wu CC, Chang CY, Tzeng CY, Huang JH, Hung CJ, Chen WY, Liao SL, Kuan YH, Chen CJ. Wu CC, et al. Int J Mol Sci. 2022 Jun 28;23(13):7197. doi: 10.3390/ijms23137197. Int J Mol Sci. 2022. PMID: 35806200 Free PMC article.
We further identified that the Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappaB inflammatory axes may each play pivotal roles in the acquisition of microglia M1 …
We further identified that the Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1
Systemic vasoprotection by inhaled carbon monoxide is mediated through prolonged alterations in monocyte/macrophage function.
Leake A, Salem K, Madigan MC, Lee GR, Shukla A, Hong G, Zuckerbraun BS, Tzeng E. Leake A, et al. Nitric Oxide. 2020 Jan 1;94:36-47. doi: 10.1016/j.niox.2019.10.003. Epub 2019 Oct 5. Nitric Oxide. 2020. PMID: 31593762 Free PMC article.
Conditioned media (CM) collected from peritoneal Mphis isolated from CO treated rats stimulated endothelial cell (EC) proliferation versus CM from Mphis from air treated rats. This effect was mediated by Mphi released VEGF and HMGB1. Inhaled CO reduced LPS induced Mphi M1 …
Conditioned media (CM) collected from peritoneal Mphis isolated from CO treated rats stimulated endothelial cell (EC) proliferation versus C …
HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer.
Huang BF, Tzeng HE, Chen PC, Wang CQ, Su CM, Wang Y, Hu GN, Zhao YM, Wang Q, Tang CH. Huang BF, et al. Int J Med Sci. 2018 Mar 12;15(6):580-586. doi: 10.7150/ijms.23462. eCollection 2018. Int J Med Sci. 2018. PMID: 29725248 Free PMC article.
Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. ...We report on the associa …
Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclea …
Chloroquine improves the response to ischemic muscle injury and increases HMGB1 after arterial ligation.
Xu J, Cui X, Li J, Koutakis P, Pipinos I, Tzeng E, Chen A, Sachdev U. Xu J, et al. J Vasc Surg. 2018 Mar;67(3):910-921. doi: 10.1016/j.jvs.2017.01.021. Epub 2017 Mar 1. J Vasc Surg. 2018. PMID: 28259568 Free PMC article.
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves angiogenesis after tissue ischemia. Antagonizing HMGB1 prolongs muscle necrosis and deters regeneration. ...In cultured myoblas …
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) imp …
HMGB1 and TLR4 mediate skeletal muscle recovery in a murine model of hindlimb ischemia.
Sachdev U, Cui X, Tzeng E. Sachdev U, et al. J Vasc Surg. 2013 Aug;58(2):460-9. doi: 10.1016/j.jvs.2012.11.071. Epub 2013 Feb 12. J Vasc Surg. 2013. PMID: 23414695 Free PMC article.
BACKGROUND: We have previously shown that the danger signal high-mobility group box 1 (HMGB1) promotes angiogenesis when administered to ischemic muscle. HMGB1 signals through Toll-like receptor 4 (TLR4) as well as the receptor for advanced glycation e …
BACKGROUND: We have previously shown that the danger signal high-mobility group box 1 (HMGB1) promotes angiogenesis when admin …
TLR2 and TLR4 mediate differential responses to limb ischemia through MyD88-dependent and independent pathways.
Sachdev U, Cui X, McEnaney R, Wang T, Benabou K, Tzeng E. Sachdev U, et al. PLoS One. 2012;7(11):e50654. doi: 10.1371/journal.pone.0050654. Epub 2012 Nov 29. PLoS One. 2012. PMID: 23209800 Free PMC article.
INTRODUCTION: The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischemia. HMGB1 is a ligand for innate immune receptors TLR2 and TLR4. While both TLR2 and TLR4 signal through myeloid differentiation fact …
INTRODUCTION: The danger signal HMGB1 is released from ischemic myocytes, and mediates angiogenesis in the setting of hindlimb ischem …
Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes.
Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. Tzeng HP, et al. Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1490-6. doi: 10.1152/ajpheart.00910.2007. Epub 2008 Jan 25. Am J Physiol Heart Circ Physiol. 2008. PMID: 18223193 Free PMC article.
High-mobility group box 1 (HMGB1) released from necrotic cells or macrophages functions as a late inflammatory mediator and has been shown to induce cardiovascular collapse during sepsis. ...The immediate negative inotropic effects of HMGB1 on cell contractil …
High-mobility group box 1 (HMGB1) released from necrotic cells or macrophages functions as a late inflammatory mediator and ha …
TLR4 Deters Perfusion Recovery and Upregulates Toll-like Receptor 2 (TLR2) in Ischemic Skeletal Muscle and Endothelial Cells.
Xu J, Benabou K, Cui X, Madia M, Tzeng E, Billiar T, Watkins S, Sachdev U. Xu J, et al. Mol Med. 2015 Jul 14;21(1):605-15. doi: 10.2119/molmed.2014.00260. Mol Med. 2015. PMID: 26181630 Free PMC article.
TLR2 expression (low in control ECs) was upregulated by lipopolysaccharide, the danger signal high mobility group box-1, and hypoxia in a TLR4-dependent manner. Endothelial tube formation on Matrigel as well as EC permeability was assessed as in vitro measures of angiogene …
TLR2 expression (low in control ECs) was upregulated by lipopolysaccharide, the danger signal high mobility group box-1, and hypoxia …
High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury.
Sachdev U, Cui X, Hong G, Namkoong S, Karlsson JM, Baty CJ, Tzeng E. Sachdev U, et al. J Vasc Surg. 2012 Jan;55(1):180-91. doi: 10.1016/j.jvs.2011.07.072. Epub 2011 Sep 23. J Vasc Surg. 2012. PMID: 21944908 Free PMC article.
Inhibition of autophagy with 3MA or chloroquine abrogated tube formation, whereas its induction with rapamycin enhanced tubing and promoted HMGB1 translocation. In vivo, ischemic skeletal muscle showed reduced numbers of HMGB1-positive myocyte nuclei compared with n …
Inhibition of autophagy with 3MA or chloroquine abrogated tube formation, whereas its induction with rapamycin enhanced tubing and promoted …