Synthesis and Characterization of New V(1A) Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers.
Szeleczky Z, Szakács Z, Bozó É, Baska F, Vukics K, Lévai S, Temesvári K, Vass E, Béni Z, Krámos B, Magdó I, Szántay C Jr, Kóti J, Domány-Kovács K, Greiner I, Bata I.
Szeleczky Z, et al.
J Med Chem. 2021 Jul 22;64(14):10445-10468. doi: 10.1021/acs.jmedchem.1c00863. Epub 2021 Jul 13.
J Med Chem. 2021.
PMID: 34255509
A new class of selective vasopressin receptor 1A (V(1A)) antagonists was identified, where "methyl-scan" was performed around the benzene ring of the 5-hydroxy-triazolobenzazepine core. ...According to the in vitro pharmacological profiles of the compounds, the human V …
A new class of selective vasopressin receptor 1A (V(1A)) antagonists was identified, where "methyl-scan" was performed around the ben …