Structure-Activity Relationship Guided Scaffold Hopping Resulted in the Identification of GLPG4970, a Highly Potent Dual SIK2/SIK3 Inhibitor.
Kelgtermans H, De Wachter M, Heyndrickx S, El Bkassiny S, Lacarriere T, Laruelle C, Heiermann J, van Bruggen W, Drabik K, Bucher D, Coudrat T, Jigorel E, Goossens K, Drennan M, Vrints M, Verbeeck M, Housmans B, Ronsse D, Moreno-Delgado D, Nassiri V, Jans M, Gees M, Wakselman E, Oste L, Borgonovi M, Borregán-Ochando E, Sushko V, Monjardet A, Dusserre C, Van Acker F, Blaauw A, Lavazais S, Jagerschmidt C, Merciris D, Török-Schafroth M, Seemayer CA, Conrath K, Kolb FA, Raboisson P, Brys R, Amantini D, Gosmini R, Denis A, Jimenez JM, De Vos S, Desroy N.
Kelgtermans H, et al. Among authors: nassiri v.
J Med Chem. 2025 Aug 14;68(15):16551-16577. doi: 10.1021/acs.jmedchem.5c01401. Epub 2025 Jul 25.
J Med Chem. 2025.
PMID: 40711360