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L-carnitine for valproic acid-induced toxicity.
Gziut T, Thanacoody R. Gziut T, et al. Br J Clin Pharmacol. 2025 Mar;91(3):636-647. doi: 10.1111/bcp.16233. Epub 2024 Sep 11. Br J Clin Pharmacol. 2025. PMID: 39261302 Free PMC article. Review.
AIMS: Review the effectiveness and dosing of L-carnitine for valproic-acid induced toxicity. METHODS: A literature review of the pharmacokinetics and clinical use of L-carnitine was performed. RESULTS: Valproic acid is a fatty acid …
AIMS: Review the effectiveness and dosing of L-carnitine for valproic-acid induced toxicity. METHODS: A literature revi …
Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis.
Guo M, Liu D, Jiang Y, Chen W, Zhao L, Bao D, Li Y, Distler JHW, Zhu H. Guo M, et al. Metabolism. 2023 Jul;144:155587. doi: 10.1016/j.metabol.2023.155587. Epub 2023 May 6. Metabolism. 2023. PMID: 37156409
The levels of allysine and all-trans-retinoic acid were negatively correlated, while D-glucuronic acid and hexanoyl carnitine were positively correlated with modified Rodnan skin score (mRSS). ...Specific metabolites identified by ML algorithms, such as medic …
The levels of allysine and all-trans-retinoic acid were negatively correlated, while D-glucuronic acid and hexanoyl carniti …
Valproic Acid-Associated Hyperammonemia: A Systematic Review.
Wong YJ, Fan J, Wan A, Mihic T, Gnyra M. Wong YJ, et al. J Clin Psychopharmacol. 2023 May-Jun 01;43(3):283-294. doi: 10.1097/JCP.0000000000001689. J Clin Psychopharmacol. 2023. PMID: 37126830
BACKGROUND: Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence of symptomatic and asymptomatic hyperammonemia and its relationship to VPA concentration is not well established. ...There was insufficient …
BACKGROUND: Hyperammonemia is an adverse effect that poses clinical uncertainty around valproic acid (VPA) use. The prevalence …
Valproic acid induced liver injury: An insight into molecular toxicological mechanism.
Ezhilarasan D, Mani U. Ezhilarasan D, et al. Environ Toxicol Pharmacol. 2022 Oct;95:103967. doi: 10.1016/j.etap.2022.103967. Epub 2022 Sep 1. Environ Toxicol Pharmacol. 2022. PMID: 36058508 Review.
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-pentenoic acid (delta(4)VPA), a metabolite of VPA, has been implicated in VPA-induced hepatotoxicity. ...The VPA induce liver injury mainly by i) liberation of delt …
Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-pentenoic acid (delta(4) …
Mechanisms involved in the valproic acid-induced hepatotoxicity: a comprehensive review.
Kadam R, Palkar M, Pingili RB. Kadam R, et al. Toxicol Mech Methods. 2025 Jul;35(6):565-580. doi: 10.1080/15376516.2025.2459176. Epub 2025 Feb 6. Toxicol Mech Methods. 2025. PMID: 39871487 Review.
An anticonvulsant medicine which is frequently used in treatment of epilepsy and other neurological conditions is valproic acid (VPA), is frequently associated with hepatotoxicity, a severe ADR that complicates its clinical use, which can take two different forms: T …
An anticonvulsant medicine which is frequently used in treatment of epilepsy and other neurological conditions is valproic acid …
Embryonic exposure to acetyl-L-carnitine protects against valproic acid-induced cardiac malformation in zebrafish model.
Rajesh V, Kokilavani A, Jayaseelan S, Gomathi S, Vishali K, Kumudhavalli MV. Rajesh V, et al. Amino Acids. 2023 May;55(5):619-638. doi: 10.1007/s00726-023-03256-7. Epub 2023 Mar 9. Amino Acids. 2023. PMID: 36894749
In earlier investigation, we explored cardiac malformation caused by valproic acid (VPA) during early developing stages of zebrafish. Since heart depends on mitochondrial fatty acid oxidative metabolism for energy demands in which carnitine shuttle has …
In earlier investigation, we explored cardiac malformation caused by valproic acid (VPA) during early developing stages of zeb …
Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons.
Salimi A, Alyan N, Akbari N, Jamali Z, Pourahmad J. Salimi A, et al. Drug Chem Toxicol. 2022 May;45(3):1150-1157. doi: 10.1080/01480545.2020.1810259. Epub 2020 Sep 4. Drug Chem Toxicol. 2022. PMID: 32885679
Sodium selenite (1 M) and L-carnitine (1 mM) pretreatment attenuated valproic acid-induced decrease in cell viability. In addition, sodium selenite (1 M) and L-carnitine (1 mM) pretreatment significantly protected against valproic acid- …
Sodium selenite (1 M) and L-carnitine (1 mM) pretreatment attenuated valproic acid-induced decrease in cell viability. …
Protective effects of L-carnitine against valproic acid-induced memory impairment and anxiety-like behavior in adult rat.
Nouri E, Karimi SA, Raoufi S, Zarei M. Nouri E, et al. Physiol Behav. 2022 Sep 1;253:113853. doi: 10.1016/j.physbeh.2022.113853. Epub 2022 May 21. Physiol Behav. 2022. PMID: 35609723
This study was designed to explore the effects of valproic acid (VPA) on spatial and passive avoidance learning and memory as well as to assess the protective effects of L-Carnitine (LC) against VPA-induced memory deficit in the rat. ...
This study was designed to explore the effects of valproic acid (VPA) on spatial and passive avoidance learning and memory as …
Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation.
Schiavo A, Maldonado C, Vázquez M, Fagiolino P, Trocóniz IF, Ibarra M. Schiavo A, et al. Eur J Pharm Sci. 2023 Apr 1;183:106399. doi: 10.1016/j.ejps.2023.106399. Epub 2023 Feb 4. Eur J Pharm Sci. 2023. PMID: 36740101 Free article.
Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy syndromes, although its therapeutic value may be undermined by its toxicity. ...This effect has been linked with reduced levels of carnitin …
Valproic acid (VPA) is a short-chain fatty acid widely prescribed in the treatment of seizure disorders and epilepsy sy …
50 results