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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1920 1
1926 1
1939 1
1945 2
1946 2
1947 5
1948 6
1949 4
1950 5
1951 8
1952 7
1953 9
1954 6
1955 4
1956 8
1957 7
1958 6
1959 6
1960 5
1961 5
1962 14
1963 15
1964 8
1965 11
1966 11
1967 17
1968 24
1969 15
1970 21
1971 11
1972 25
1973 22
1974 25
1975 137
1976 121
1977 122
1978 115
1979 94
1980 100
1981 92
1982 80
1983 142
1984 112
1985 128
1986 133
1987 149
1988 194
1989 241
1990 224
1991 243
1992 261
1993 312
1994 350
1995 352
1996 386
1997 378
1998 390
1999 375
2000 482
2001 414
2002 433
2003 430
2004 498
2005 473
2006 490
2007 504
2008 590
2009 527
2010 594
2011 593
2012 629
2013 704
2014 733
2015 819
2016 806
2017 763
2018 694
2019 682
2020 767
2021 802
2022 72
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17,473 results
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Page 1
On Mammalian Totipotency: What Is the Molecular Underpinning for the Totipotency of Zygote?
Hu K. Hu K. Stem Cells Dev. 2019 Jul 15;28(14):897-906. doi: 10.1089/scd.2019.0057. Stem Cells Dev. 2019. PMID: 31122174 Free PMC article. Review.
Here, the implications of these concepts are discussed in the context of the properties of the zygote. Although genetically totipotent as any diploid somatic cell is, a zygote seems not totipotent transcriptionally, epigenetically, or functionally. Yet, a zygote
Here, the implications of these concepts are discussed in the context of the properties of the zygote. Although genetically totipoten …
Totipotency continuity from zygote to early blastomeres: a model under revision.
Boiani M, Casser E, Fuellen G, Christians ES. Boiani M, et al. Reproduction. 2019 Aug;158(2):R49-R65. doi: 10.1530/REP-18-0462. Reproduction. 2019. PMID: 30978695 Review.
The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. ...We were, thus, led to propose a revised model for totipotency continuity based on the construction of the zygote as a mosaic, which accounts fo …
The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. ...We were, t …
ORC proteins in the mammalian zygote.
Ortega MA, Nguyen H, Ward WS. Ortega MA, et al. Cell Tissue Res. 2016 Jan;363(1):195-200. doi: 10.1007/s00441-015-2296-3. Epub 2015 Oct 9. Cell Tissue Res. 2016. PMID: 26453397 Free PMC article. Review.
These proteins have complex mechanisms of assembly into the ORC complex and unexpected localizations in the mitotic chromosomes, cytoplasm, and nuclear structures. The mammalian zygote is a potentially important model that may contribute to our understanding of the mechani …
These proteins have complex mechanisms of assembly into the ORC complex and unexpected localizations in the mitotic chromosomes, cytoplasm, …
Zygote Electroporation for CRISPR/Cas9 Delivery to Generate Genetically Modified Mice.
Takemoto T. Takemoto T. Methods Mol Biol. 2020;2050:121-126. doi: 10.1007/978-1-4939-9740-4_13. Methods Mol Biol. 2020. PMID: 31468486
In conventional protocols, Cas9 protein (or mRNA) and sgRNA are introduced into zygotes by microinjection. However, microinjection requires special skill and is too time-consuming to treat zygotes on a large scale. ...
In conventional protocols, Cas9 protein (or mRNA) and sgRNA are introduced into zygotes by microinjection. However, microinjection re …
Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
Fraser R, Lin CJ. Fraser R, et al. Reproduction. 2016 Dec;152(6):R211-R222. doi: 10.1530/REP-16-0376. Epub 2016 Sep 6. Reproduction. 2016. PMID: 27601712 Free PMC article. Review.
Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal an …
Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce tot …
How can zygotes segregate entire parental genomes into distinct blastomeres? The zygote metaphase revisited.
Destouni A, Vermeesch JR. Destouni A, et al. Bioessays. 2017 Apr;39(4). doi: 10.1002/bies.201600226. Epub 2017 Mar 1. Bioessays. 2017. PMID: 28247957 Review.
Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each parental genome. ...Here, we speculate on which parental genome asymmetries could provide a mechanistic foundation for these remarkable zygote divisions. In reviewing the field and
Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each parental genome. ...Here, we speculate on which
Development of polyspermic zygote and possible contribution of polyspermy to polyploid formation in angiosperms.
Okamoto T, Ohnishi Y, Toda E. Okamoto T, et al. J Plant Res. 2017 May;130(3):485-490. doi: 10.1007/s10265-017-0913-9. Epub 2017 Mar 8. J Plant Res. 2017. PMID: 28275885 Review.
One of the reasons why polyspermy is regarded as uncommon is because it is difficult to reproduce the polyspermy situation in zygotes and to analyze the developmental profiles of polyspermic triploid zygotes. ...Two sperm nuclei and an egg nucleus fused into a zy
One of the reasons why polyspermy is regarded as uncommon is because it is difficult to reproduce the polyspermy situation in zygotes
The maternal to zygotic transition in mammals.
Li L, Lu X, Dean J. Li L, et al. Mol Aspects Med. 2013 Oct;34(5):919-38. doi: 10.1016/j.mam.2013.01.003. Epub 2013 Jan 23. Mol Aspects Med. 2013. PMID: 23352575 Free PMC article. Review.
Following gamete union, the transcriptionally inert sperm DNA is repackaged into the male pronucleus which fuses with the female pronucleus to form a 1-cell zygote. Embryonic transcription begins during the maternal to zygotic transfer of control in directing develo …
Following gamete union, the transcriptionally inert sperm DNA is repackaged into the male pronucleus which fuses with the female pronucleus …
Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance.
Vještica A, Bérard M, Liu G, Merlini L, Nkosi PJ, Martin SG. Vještica A, et al. PLoS Biol. 2021 Jan 6;19(1):e3001067. doi: 10.1371/journal.pbio.3001067. eCollection 2021 Jan. PLoS Biol. 2021. PMID: 33406066 Free PMC article.
Using long-term imaging and flow-cytometry approaches, we identify previously unrecognized and independent roles for Mei3 and Mei2 in zygotes. We show that Mei3 promotes premeiotic S-phase independently of Mei2 and that cell cycle progression is both necessary and s …
Using long-term imaging and flow-cytometry approaches, we identify previously unrecognized and independent roles for Mei3 and Mei2 in zyg
Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development.
Zhu HY, Kang XJ, Jin L, Zhang PY, Wu H, Tan T, Yu Y, Fan Y. Zhu HY, et al. Mol Hum Reprod. 2021 Feb 27;27(3):gaab012. doi: 10.1093/molehr/gaab012. Mol Hum Reprod. 2021. PMID: 33599278 Free PMC article.
Human zygotes are difficult to obtain for research because of limited resources and ethical debates. Corrected human tripronuclear (ch3PN) zygotes obtained by removal of the extra pronucleus from abnormally fertilized tripronuclear (3PN) zygotes are considere …
Human zygotes are difficult to obtain for research because of limited resources and ethical debates. Corrected human tripronuclear (c …
17,473 results
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