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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1920 1
1926 1
1939 1
1945 2
1946 2
1947 5
1948 6
1949 4
1950 5
1951 8
1952 7
1953 9
1954 6
1955 4
1956 8
1957 7
1958 6
1959 6
1960 5
1961 5
1962 14
1963 15
1964 8
1965 11
1966 11
1967 17
1968 24
1969 15
1970 21
1971 11
1972 25
1973 22
1974 25
1975 137
1976 122
1977 122
1978 116
1979 94
1980 101
1981 92
1982 80
1983 142
1984 112
1985 130
1986 133
1987 149
1988 197
1989 242
1990 224
1991 247
1992 264
1993 316
1994 350
1995 356
1996 389
1997 378
1998 390
1999 375
2000 481
2001 414
2002 433
2003 430
2004 498
2005 473
2006 489
2007 504
2008 590
2009 527
2010 594
2011 593
2012 629
2013 704
2014 733
2015 819
2016 806
2017 763
2018 695
2019 682
2020 774
2021 809
2022 759
2023 630
2024 244

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18,871 results

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Page 1
The maternal to zygotic transition in mammals.
Li L, Lu X, Dean J. Li L, et al. Mol Aspects Med. 2013 Oct;34(5):919-38. doi: 10.1016/j.mam.2013.01.003. Epub 2013 Jan 23. Mol Aspects Med. 2013. PMID: 23352575 Free PMC article. Review.
Following gamete union, the transcriptionally inert sperm DNA is repackaged into the male pronucleus which fuses with the female pronucleus to form a 1-cell zygote. Embryonic transcription begins during the maternal to zygotic transfer of control in directing develo …
Following gamete union, the transcriptionally inert sperm DNA is repackaged into the male pronucleus which fuses with the female pronucleus …
ORC proteins in the mammalian zygote.
Ortega MA, Nguyen H, Ward WS. Ortega MA, et al. Cell Tissue Res. 2016 Jan;363(1):195-200. doi: 10.1007/s00441-015-2296-3. Epub 2015 Oct 9. Cell Tissue Res. 2016. PMID: 26453397 Free PMC article. Review.
These proteins have complex mechanisms of assembly into the ORC complex and unexpected localizations in the mitotic chromosomes, cytoplasm, and nuclear structures. The mammalian zygote is a potentially important model that may contribute to our understanding of the mechani …
These proteins have complex mechanisms of assembly into the ORC complex and unexpected localizations in the mitotic chromosomes, cytoplasm, …
Totipotency continuity from zygote to early blastomeres: a model under revision.
Boiani M, Casser E, Fuellen G, Christians ES. Boiani M, et al. Reproduction. 2019 Aug;158(2):R49-R65. doi: 10.1530/REP-18-0462. Reproduction. 2019. PMID: 30978695 Review.
The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. ...We were, thus, led to propose a revised model for totipotency continuity based on the construction of the zygote as a mosaic, which accounts fo …
The mammalian zygote is a totipotent cell that generates all the cells of a new organism through embryonic development. ...We were, t …
Function of atypical mammalian oocyte/zygote nucleoli and its implications for reproductive biology and medicine.
Fulka JJ, Benc M, Loi P, Langerova A, Fulka H. Fulka JJ, et al. Int J Dev Biol. 2019;63(3-4-5):105-112. doi: 10.1387/ijdb.180329jf. Int J Dev Biol. 2019. PMID: 31058290 Free article. Review.
Mammalian oocytes/zygotes contain atypical nucleoli that are composed exclusively of a dense fibrillar material. ...Nevertheless, it still remains to be determined, which other functions/roles the atypical oocyte/zygote nucleoli eventually have....
Mammalian oocytes/zygotes contain atypical nucleoli that are composed exclusively of a dense fibrillar material. ...Nevertheless, it …
Epigenetic reprogramming of the zygote in mice and men: on your marks, get set, go!
Fraser R, Lin CJ. Fraser R, et al. Reproduction. 2016 Dec;152(6):R211-R222. doi: 10.1530/REP-16-0376. Epub 2016 Sep 6. Reproduction. 2016. PMID: 27601712 Free PMC article. Review.
Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal an …
Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce tot …
Development of polyspermic zygote and possible contribution of polyspermy to polyploid formation in angiosperms.
Okamoto T, Ohnishi Y, Toda E. Okamoto T, et al. J Plant Res. 2017 May;130(3):485-490. doi: 10.1007/s10265-017-0913-9. Epub 2017 Mar 8. J Plant Res. 2017. PMID: 28275885 Review.
One of the reasons why polyspermy is regarded as uncommon is because it is difficult to reproduce the polyspermy situation in zygotes and to analyze the developmental profiles of polyspermic triploid zygotes. ...Two sperm nuclei and an egg nucleus fused into a zy …
One of the reasons why polyspermy is regarded as uncommon is because it is difficult to reproduce the polyspermy situation in zygotes …
How can zygotes segregate entire parental genomes into distinct blastomeres? The zygote metaphase revisited.
Destouni A, Vermeesch JR. Destouni A, et al. Bioessays. 2017 Apr;39(4). doi: 10.1002/bies.201600226. Epub 2017 Mar 1. Bioessays. 2017. PMID: 28247957 Review.
Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each parental genome. ...Here, we speculate on which parental genome asymmetries could provide a mechanistic foundation for these remarkable zygote divisions. In reviewing the field and …
Zygote cytokinesis produces two symmetric blastomeres, which contain one copy of each parental genome. ...Here, we speculate on which …
A zygote-based assay to evaluate intranuclear shuttling in S. cerevisiae.
Tartakoff AM. Tartakoff AM. STAR Protoc. 2021 Aug 12;2(3):100736. doi: 10.1016/j.xpro.2021.100736. eCollection 2021 Sep 17. STAR Protoc. 2021. PMID: 34430911 Free PMC article.
This protocol makes it possible to learn whether individual nucleolar proteins in S. cerevisiae remain in place or depart from and return to the nucleolus. The protocol uses early zygotes in which parental nucleoli are separate for at least one hour. ...
This protocol makes it possible to learn whether individual nucleolar proteins in S. cerevisiae remain in place or depart from and return to …
Zygote Electroporation for CRISPR/Cas9 Delivery to Generate Genetically Modified Mice.
Takemoto T. Takemoto T. Methods Mol Biol. 2020;2050:121-126. doi: 10.1007/978-1-4939-9740-4_13. Methods Mol Biol. 2020. PMID: 31468486
In conventional protocols, Cas9 protein (or mRNA) and sgRNA are introduced into zygotes by microinjection. However, microinjection requires special skill and is too time-consuming to treat zygotes on a large scale. ...
In conventional protocols, Cas9 protein (or mRNA) and sgRNA are introduced into zygotes by microinjection. However, microinjection re …
Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition.
Zhang C, Wang M, Li Y, Zhang Y. Zhang C, et al. Sci Adv. 2022 Feb 4;8(5):eabj3967. doi: 10.1126/sciadv.abj3967. Epub 2022 Feb 2. Sci Adv. 2022. PMID: 35108058 Free PMC article.
We identified a marked translational transition from MII oocytes to zygotes and demonstrated that active translation of maternal mRNAs is essential for maternal-to-zygotic transition (MZT). We further showed that two maternal factors, Smarcd2 and Cyclin T2, whose tr …
We identified a marked translational transition from MII oocytes to zygotes and demonstrated that active translation of maternal mRNA …
18,871 results
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